decreased cell proliferation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduction in the expansion rate of a cell population by cell division (Mammalian Phenotype Ontology, MP_0000352)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000352
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Genes

328 gene mutations causing the decreased cell proliferation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
A1CF APOBEC1 complementation factor
AATF apoptosis antagonizing transcription factor
AEBP1 AE binding protein 1
AIRE autoimmune regulator
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2
ARHGAP1 Rho GTPase activating protein 1
ATF4 activating transcription factor 4
ATF6 activating transcription factor 6
ATM ATM serine/threonine kinase
ATMIN ATM interactor
BARX1 BARX homeobox 1
BIRC6 baculoviral IAP repeat containing 6
BMPR1A bone morphogenetic protein receptor, type IA
BMPR1B bone morphogenetic protein receptor, type IB
BPTF bromodomain PHD finger transcription factor
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRD2 bromodomain containing 2
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1QBP complement component 1, q subcomponent binding protein
C3 complement component 3
CACFD1 calcium channel flower domain containing 1
CAV1 caveolin 1, caveolae protein, 22kDa
CBX2 chromobox homolog 2
CCNDBP1 cyclin D-type binding-protein 1
CCNF cyclin F
CCR2 chemokine (C-C motif) receptor 2
CD151 CD151 molecule (Raph blood group)
CD247 CD247 molecule
CD34 CD34 molecule
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC20 cell division cycle 20
CDK11A cyclin-dependent kinase 11A
CDK2 cyclin-dependent kinase 2
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHD7 chromodomain helicase DNA binding protein 7
CHEK1 checkpoint kinase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIB1 calcium and integrin binding 1 (calmyrin)
CIRBP cold inducible RNA binding protein
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
COMMD3-BMI1 COMMD3-BMI1 readthrough
COPS5 COP9 signalosome subunit 5
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CRLF2 cytokine receptor-like factor 2
CSPG4 chondroitin sulfate proteoglycan 4
CTC1 CTS telomere maintenance complex component 1
CTGF connective tissue growth factor
CTNND1 catenin (cadherin-associated protein), delta 1
CUL4A cullin 4A
CUL4B cullin 4B
CUX2 cut-like homeobox 2
CXCL10 chemokine (C-X-C motif) ligand 10
DCBLD2 discoidin, CUB and LCCL domain containing 2
DCLRE1A DNA cross-link repair 1A
DDR2 discoidin domain receptor tyrosine kinase 2
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DICER1 dicer 1, ribonuclease type III
DIDO1 death inducer-obliterator 1
DNM1L dynamin 1-like
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DOT1L DOT1-like histone H3K79 methyltransferase
DPH1 diphthamide biosynthesis 1
DSG2 desmoglein 2
E2F3 E2F transcription factor 3
ECSIT ECSIT signalling integrator
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EP300 E1A binding protein p300
ERCC1 excision repair cross-complementation group 1
ERI1 exoribonuclease 1
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EYA1 EYA transcriptional coactivator and phosphatase 1
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAT4 FAT atypical cadherin 4
FBLIM1 filamin binding LIM protein 1
FEN1 flap structure-specific endonuclease 1
FENDRR FOXF1 adjacent non-coding developmental regulatory RNA
FERMT1 fermitin family member 1
FGFRL1 fibroblast growth factor receptor-like 1
FN1 fibronectin 1
FNDC3B fibronectin type III domain containing 3B
FNTB farnesyltransferase, CAAX box, beta
FOXD3 forkhead box D3
FOXM1 forkhead box M1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1
GAS6 growth arrest-specific 6
GATA4 GATA binding protein 4
GCLC glutamate-cysteine ligase, catalytic subunit
GIPC1 GIPC PDZ domain containing family, member 1
GLI2 GLI family zinc finger 2
GLRX glutaredoxin (thioltransferase)
GLRX3 glutaredoxin 3
GMNN geminin, DNA replication inhibitor
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GNPNAT1 glucosamine-phosphate N-acetyltransferase 1
GPX1 glutathione peroxidase 1
GTF2I general transcription factor IIi
H2AFX H2A histone family, member X
HAND1 heart and neural crest derivatives expressed 1
HAT1 histone acetyltransferase 1
HDAC1 histone deacetylase 1
HDAC3 histone deacetylase 3
HDGFRP2 hepatoma-derived growth factor-related protein 2
HELLS helicase, lymphoid-specific
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIPK2 homeodomain interacting protein kinase 2
HSPB1 heat shock 27kDa protein 1
HTT huntingtin
HUS1 HUS1 checkpoint homolog (S. pombe)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IL17C interleukin 17C
IL6R interleukin 6 receptor
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1
INSM1 insulinoma-associated 1
IRS1 insulin receptor substrate 1
ITGA11 integrin, alpha 11
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JUN jun proto-oncogene
JUND jun D proto-oncogene
KAT2A K(lysine) acetyltransferase 2A
KDM4B lysine (K)-specific demethylase 4B
KDM8 lysine (K)-specific demethylase 8
KIF14 kinesin family member 14
KIF18A kinesin family member 18A
KITLG KIT ligand
KLF6 Kruppel-like factor 6
KMT2A lysine (K)-specific methyltransferase 2A
KMT2C lysine (K)-specific methyltransferase 2C
KSR1 kinase suppressor of ras 1
LATS2 large tumor suppressor kinase 2
LIG1 ligase I, DNA, ATP-dependent
LIG4 ligase IV, DNA, ATP-dependent
LIMS1 LIM and senescent cell antigen-like domains 1
LMNA lamin A/C
LMNB1 lamin B1
LTB4R leukotriene B4 receptor
LZTS1 leucine zipper, putative tumor suppressor 1
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast)
MAP2K5 mitogen-activated protein kinase kinase 5
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK3 mitogen-activated protein kinase 3
MASTL microtubule associated serine/threonine kinase-like
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MCM8 minichromosome maintenance complex component 8
MCM9 minichromosome maintenance complex component 9
MDC1 mediator of DNA-damage checkpoint 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MED1 mediator complex subunit 1
MED31 mediator complex subunit 31
METAP2 methionyl aminopeptidase 2
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIS18A MIS18 kinetochore protein A
MMP13 matrix metallopeptidase 13
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MORF4L1 mortality factor 4 like 1
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUS81 MUS81 structure-specific endonuclease subunit
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NCOA3 nuclear receptor coactivator 3
NCOA6 nuclear receptor coactivator 6
NFE2L2 nuclear factor, erythroid 2-like 2
NFYA nuclear transcription factor Y, alpha
NKX2-5 NK2 homeobox 5
NKX3-2 NK3 homeobox 2
NLRP3 NLR family, pyrin domain containing 3
NOA1 nitric oxide associated 1
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH2 notch 2
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR1I2 nuclear receptor subfamily 1, group I, member 2
NRF1 nuclear respiratory factor 1
NRP2 neuropilin 2
NTAN1 N-terminal asparagine amidase
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PA2G4 proliferation-associated 2G4, 38kDa
PAK1IP1 PAK1 interacting protein 1
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PARG poly (ADP-ribose) glycohydrolase
PARP1 poly (ADP-ribose) polymerase 1
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PAX1 paired box 1
PAX3 paired box 3
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PDCD1 programmed cell death 1
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDS5B PDS5 cohesin associated factor B
PER2 period circadian clock 2
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PGR progesterone receptor
PHB2 prohibitin 2
PHC2 polyhomeotic homolog 2 (Drosophila)
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive)
PLRG1 pleiotropic regulator 1
POLB polymerase (DNA directed), beta
POT1 protection of telomeres 1
POU3F3 POU class 3 homeobox 3
PPARD peroxisome proliferator-activated receptor delta
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PPP5C protein phosphatase 5, catalytic subunit
PRDX1 peroxiredoxin 1
PRKCQ protein kinase C, theta
PRMT6 protein arginine methyltransferase 6
PROX1 prospero homeobox 1
PRPF19 pre-mRNA processing factor 19
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PTGES3 prostaglandin E synthase 3 (cytosolic)
PTHLH parathyroid hormone-like hormone
PTK2 protein tyrosine kinase 2
PTP4A2 protein tyrosine phosphatase type IVA, member 2
PTPMT1 protein tyrosine phosphatase, mitochondrial 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTTG1 pituitary tumor-transforming 1
PURA purine-rich element binding protein A
PXDN peroxidasin
PYGO2 pygopus family PHD finger 2
RAD50 RAD50 homolog (S. cerevisiae)
RAD51 RAD51 recombinase
RAD54L2 RAD54-like 2 (S. cerevisiae)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RBM3 RNA binding motif (RNP1, RRM) protein 3
RBX1 ring-box 1, E3 ubiquitin protein ligase
RECQL RecQ helicase-like
REG1B regenerating islet-derived 1 beta
RHEB Ras homolog enriched in brain
RICTOR RPTOR independent companion of MTOR, complex 2
RIF1 replication timing regulatory factor 1
RNASEH2B ribonuclease H2, subunit B
RNF7 ring finger protein 7
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RPA1 replication protein A1, 70kDa
RPL29 ribosomal protein L29
RXRA retinoid X receptor, alpha
SALL4 spalt-like transcription factor 4
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERTAD2 SERTA domain containing 2
SESN2 sestrin 2
SETDB1 SET domain, bifurcated 1
SHH sonic hedgehog
SIRT2 sirtuin 2
SIRT6 sirtuin 6
SIX1 SIX homeobox 1
SKIL SKI-like proto-oncogene
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD4 SMAD family member 4
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SOD1 superoxide dismutase 1, soluble
SP2 Sp2 transcription factor
SPTBN1 spectrin, beta, non-erythrocytic 1
SSBP3 single stranded DNA binding protein 3
STAG1 stromal antigen 1
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STIP1 stress-induced phosphoprotein 1
SUZ12 SUZ12 polycomb repressive complex 2 subunit
T T, brachyury homolog (mouse)
TADA3 transcriptional adaptor 3
TASP1 taspase, threonine aspartase, 1
TCEB3 transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)
TDGF1 teratocarcinoma-derived growth factor 1
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TERT telomerase reverse transcriptase
TGIF1 TGFB-induced factor homeobox 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TICAM1 toll-like receptor adaptor molecule 1
TJP2 tight junction protein 2
TLN2 talin 2
TLR2 toll-like receptor 2
TLR7 toll-like receptor 7
TNF tumor necrosis factor
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TNRC6A trinucleotide repeat containing 6A
TOP1MT topoisomerase (DNA) I, mitochondrial
TOPBP1 topoisomerase (DNA) II binding protein 1
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP63 tumor protein p63
TPT1 tumor protein, translationally-controlled 1
TPX2 TPX2, microtubule-associated
TRAIP TRAF interacting protein
TSG101 tumor susceptibility 101
TSN translin
TXNRD1 thioredoxin reductase 1
TXNRD2 thioredoxin reductase 2
UBC ubiquitin C
UBR5 ubiquitin protein ligase E3 component n-recognin 5
UIMC1 ubiquitin interaction motif containing 1
UTF1 undifferentiated embryonic cell transcription factor 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VPRBP Vpr (HIV-1) binding protein
WASL Wiskott-Aldrich syndrome-like
WNT2 wingless-type MMTV integration site family member 2
WNT6 wingless-type MMTV integration site family, member 6
XBP1 X-box binding protein 1
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YBX1 Y box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YY1 YY1 transcription factor
ZBTB17 zinc finger and BTB domain containing 17
ZBTB7C zinc finger and BTB domain containing 7C
ZFP36L1 ZFP36 ring finger protein-like 1
ZMIZ1 zinc finger, MIZ-type containing 1