decreased cell death Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description decreased occurrence of the cessation of function at the cellular level (Mammalian Phenotype Ontology, MP_0012555)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0012555
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Genes

174 gene mutations causing the decreased cell death phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AGER advanced glycosylation end product-specific receptor
AGTR2 angiotensin II receptor, type 2
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
APAF1 apoptotic peptidase activating factor 1
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BAG6 BCL2-associated athanogene 6
BAX BCL2-associated X protein
BBC3 BCL2 binding component 3
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL2L12 BCL2-like 12 (proline rich)
BID BH3 interacting domain death agonist
BIRC3 baculoviral IAP repeat containing 3
BMF Bcl2 modifying factor
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C9ORF114 chromosome 9 open reading frame 114
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CASP12 caspase 12 (gene/pseudogene)
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCDC86 coiled-coil domain containing 86
CCL13 chemokine (C-C motif) ligand 13
CD247 CD247 molecule
CD274 CD274 molecule
CD44 CD44 molecule (Indian blood group)
CDK6 cyclin-dependent kinase 6
CDX2 caudal type homeobox 2
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHEK2 checkpoint kinase 2
CNBP CCHC-type zinc finger, nucleic acid binding protein
CTSB cathepsin B
CXCR4 chemokine (C-X-C motif) receptor 4
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DAP3 death associated protein 3
DAPK1 death-associated protein kinase 1
DCC DCC netrin 1 receptor
DDIT3 DNA-damage-inducible transcript 3
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide
DNASE1 deoxyribonuclease I
DNM1L dynamin 1-like
DTX1 deltex 1, E3 ubiquitin ligase
DUSP4 dual specificity phosphatase 4
E2F1 E2F transcription factor 1
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1
EGLN3 egl-9 family hypoxia-inducible factor 3
ENDOG endonuclease G
ERO1L ERO1-like (S. cerevisiae)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FADD Fas (TNFRSF6)-associated via death domain
FAF1 Fas (TNFRSF6) associated factor 1
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FGF8 fibroblast growth factor 8 (androgen-induced)
FOXO3 forkhead box O3
GLIPR1 GLI pathogenesis-related 1
GLRX glutaredoxin (thioltransferase)
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRM2 glutamate receptor, metabotropic 2
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HAVCR2 hepatitis A virus cellular receptor 2
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIPK2 homeodomain interacting protein kinase 2
HIST1H2BJ histone cluster 1, H2bj
HRK harakiri, BCL2 interacting protein
IFNG interferon, gamma
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRF3 interferon regulatory factor 3
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
JUN jun proto-oncogene
KLF13 Kruppel-like factor 13
LCN2 lipocalin 2
LRP5 low density lipoprotein receptor-related protein 5
MAGED1 melanoma antigen family D1
MAOB monoamine oxidase B
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K6 mitogen-activated protein kinase kinase 6
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAPK10 mitogen-activated protein kinase 10
MAPK8 mitogen-activated protein kinase 8
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MAPK9 mitogen-activated protein kinase 9
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPT microtubule-associated protein tau
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MEFV Mediterranean fever
MMP9 matrix metallopeptidase 9
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC2 mucin 2, oligomeric mucus/gel-forming
MUTYH mutY homolog
NCOA3 nuclear receptor coactivator 3
NDRG1 N-myc downstream regulated 1
NGFR nerve growth factor receptor
NOA1 nitric oxide associated 1
NOS1 nitric oxide synthase 1 (neuronal)
NOX4 NADPH oxidase 4
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NTF4 neurotrophin 4
OTUD7B OTU deubiquitinase 7B
PACS2 phosphofurin acidic cluster sorting protein 2
PANX1 pannexin 1
PARP1 poly (ADP-ribose) polymerase 1
PAWR PRKC, apoptosis, WT1, regulator
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PERP PERP, TP53 apoptosis effector
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PKN1 protein kinase N1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLG plasminogen
PPP1R9B protein phosphatase 1, regulatory subunit 9B
PRF1 perforin 1 (pore forming protein)
PRKCE protein kinase C, epsilon
PRKCQ protein kinase C, theta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RASD1 RAS, dexamethasone-induced 1
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RB1 retinoblastoma 1
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RET ret proto-oncogene
RHOH ras homolog family member H
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
S1PR2 sphingosine-1-phosphate receptor 2
SARM1 sterile alpha and TIR motif containing 1
SH3GLB1 SH3-domain GRB2-like endophilin B1
SIM1 single-minded family bHLH transcription factor 1
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SMAD3 SMAD family member 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNCG synuclein, gamma (breast cancer-specific protein 1)
SOSTDC1 sclerostin domain containing 1
SPP1 secreted phosphoprotein 1
SPPL2A signal peptide peptidase like 2A
SRR serine racemase
STAT1 signal transducer and activator of transcription 1, 91kDa
STEAP3 STEAP family member 3, metalloreductase
STIM2 stromal interaction molecule 2
SURF1 surfeit 1
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
TGFB3 transforming growth factor, beta 3
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TICAM1 toll-like receptor adaptor molecule 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TMEM109 transmembrane protein 109
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TP53 tumor protein p53
TP63 tumor protein p63
TRADD TNFRSF1A-associated via death domain
TREX2 three prime repair exonuclease 2
TRIM27 tripartite motif containing 27
TRPC5 transient receptor potential cation channel, subfamily C, member 5
UBE2K ubiquitin-conjugating enzyme E2K
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UNC5A unc-5 homolog A (C. elegans)
WDR83 WD repeat domain 83