decreased cd8-positive, alpha-beta t cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions (Mammalian Phenotype Ontology, MP_0008079)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008079
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Genes

131 gene mutations causing the decreased cd8-positive, alpha-beta t cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACP2 acid phosphatase 2, lysosomal
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARL4D ADP-ribosylation factor-like 4D
ATM ATM serine/threonine kinase
B2M beta-2-microglobulin
BCL2 B-cell CLL/lymphoma 2
BCLAF1 BCL2-associated transcription factor 1
CADM1 cell adhesion molecule 1
CCR1 chemokine (C-C motif) receptor 1
CCR6 chemokine (C-C motif) receptor 6
CD247 CD247 molecule
CD274 CD274 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD70 CD70 molecule
CD8A CD8a molecule
CD8B CD8b molecule
CDK6 cyclin-dependent kinase 6
CLEC10A C-type lectin domain family 10, member A
CORO1A coronin, actin binding protein, 1A
CXCL10 chemokine (C-X-C motif) ligand 10
CYLD cylindromatosis (turban tumor syndrome)
DCLRE1C DNA cross-link repair 1C
DGKZ diacylglycerol kinase, zeta
DIAPH1 diaphanous-related formin 1
DLL1 delta-like 1 (Drosophila)
DOCK2 dedicator of cytokinesis 2
DOCK8 dedicator of cytokinesis 8
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAS Fas cell surface death receptor
GCLC glutamate-cysteine ligase, catalytic subunit
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
GPER1 G protein-coupled estrogen receptor 1
GRAP2 GRB2-related adaptor protein 2
HAX1 HCLS1 associated protein X-1
HCST hematopoietic cell signal transducer
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HLA-A major histocompatibility complex, class I, A
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFNGR1 interferon gamma receptor 1
IGHM immunoglobulin heavy constant mu
IL15 interleukin 15
IL15RA interleukin 15 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
IL7R interleukin 7 receptor
IRF1 interferon regulatory factor 1
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITK IL2-inducible T-cell kinase
ITPKB inositol-trisphosphate 3-kinase B
JAK3 Janus kinase 3
KAZN kazrin, periplakin interacting protein
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAT linker for activation of T cells
LBR lamin B receptor
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LIG4 ligase IV, DNA, ATP-dependent
LRFN2 leucine rich repeat and fibronectin type III domain containing 2
MAVS mitochondrial antiviral signaling protein
MCL1 myeloid cell leukemia 1
MMP19 matrix metallopeptidase 19
MSI2 musashi RNA-binding protein 2
NCAPH2 non-SMC condensin II complex, subunit H2
NCKAP1L NCK-associated protein 1-like
NCR1 natural cytotoxicity triggering receptor 1
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLRC5 NLR family, CARD domain containing 5
NPY1R neuropeptide Y receptor Y1
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAX1 paired box 1
PBX1 pre-B-cell leukemia homeobox 1
PDCD1 programmed cell death 1
PDCD1LG2 programmed cell death 1 ligand 2
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLA2G10 phospholipase A2, group X
PNP purine nucleoside phosphorylase
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRKCH protein kinase C, eta
PRKCQ protein kinase C, theta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRSS50 protease, serine, 50
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSMB11 proteasome (prosome, macropain) subunit, beta type, 11
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTPRC protein tyrosine phosphatase, receptor type, C
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RASA3 RAS p21 protein activator 3
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBBP7 retinoblastoma binding protein 7
RHOH ras homolog family member H
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RORC RAR-related orphan receptor C
RPL22 ribosomal protein L22
RUVBL2 RuvB-like AAA ATPase 2
SGMS1 sphingomyelin synthase 1
SGPL1 sphingosine-1-phosphate lyase 1
SIRT1 sirtuin 1
SIT1 signaling threshold regulating transmembrane adaptor 1
SPI1 Spi-1 proto-oncogene
SPNS2 spinster homolog 2 (Drosophila)
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
STAT5B signal transducer and activator of transcription 5B
STK4 serine/threonine kinase 4
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TAPBP TAP binding protein (tapasin)
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TESPA1 thymocyte expressed, positive selection associated 1
THEMIS thymocyte selection associated
TICAM1 toll-like receptor adaptor molecule 1
TMEM189 transmembrane protein 189
TPP2 tripeptidyl peptidase II
TXNIP thioredoxin interacting protein
VAV1 vav 1 guanine nucleotide exchange factor
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZBTB1 zinc finger and BTB domain containing 1
ZBTB7B zinc finger and BTB domain containing 7B
ZEB1 zinc finger E-box binding homeobox 1
ZNF335 zinc finger protein 335