decreased cd4-positive, alpha beta t cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production (Mammalian Phenotype Ontology, MP_0008075)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008075
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Genes

160 gene mutations causing the decreased cd4-positive, alpha beta t cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACP2 acid phosphatase 2, lysosomal
AP1G1 adaptor-related protein complex 1, gamma 1 subunit
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARID5A AT rich interactive domain 5A (MRF1-like)
ASXL1 additional sex combs like transcriptional regulator 1
ATM ATM serine/threonine kinase
BATF basic leucine zipper transcription factor, ATF-like
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL6 B-cell CLL/lymphoma 6
BMF Bcl2 modifying factor
C17ORF62 chromosome 17 open reading frame 62
CADM1 cell adhesion molecule 1
CCL5 chemokine (C-C motif) ligand 5
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CCR6 chemokine (C-C motif) receptor 6
CCR7 chemokine (C-C motif) receptor 7
CD247 CD247 molecule
CD274 CD274 molecule
CD28 CD28 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD4 CD4 molecule
CD5 CD5 molecule
CD69 CD69 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD83 CD83 molecule
CD84 CD84 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIITA class II, major histocompatibility complex, transactivator
CLEC10A C-type lectin domain family 10, member A
CORO1A coronin, actin binding protein, 1A
CTSV cathepsin V
CYLD cylindromatosis (turban tumor syndrome)
DCK deoxycytidine kinase
DCLRE1C DNA cross-link repair 1C
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DGKZ diacylglycerol kinase, zeta
DIAPH1 diaphanous-related formin 1
DLL1 delta-like 1 (Drosophila)
DOCK2 dedicator of cytokinesis 2
DOCK8 dedicator of cytokinesis 8
EBI3 Epstein-Barr virus induced 3
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAS Fas cell surface death receptor
FBXO7 F-box protein 7
FOXN1 forkhead box N1
FOXP3 forkhead box P3
GCLC glutamate-cysteine ligase, catalytic subunit
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
GPER1 G protein-coupled estrogen receptor 1
GPR15 G protein-coupled receptor 15
GPR83 G protein-coupled receptor 83
GRAP2 GRB2-related adaptor protein 2
HAX1 HCLS1 associated protein X-1
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HNRNPLL heterogeneous nuclear ribonucleoprotein L-like
ICOS inducible T-cell co-stimulator
IFNGR1 interferon gamma receptor 1
IGHM immunoglobulin heavy constant mu
IL13 interleukin 13
IL17A interleukin 17A
IL17C interleukin 17C
IL2 interleukin 2
IL21 interleukin 21
IL21R interleukin 21 receptor
IL4R interleukin 4 receptor
IL5RA interleukin 5 receptor, alpha
IL7R interleukin 7 receptor
ITFG2 integrin alpha FG-GAP repeat containing 2
ITGAD integrin, alpha D
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB7 integrin, beta 7
ITK IL2-inducible T-cell kinase
ITPKB inositol-trisphosphate 3-kinase B
JAK3 Janus kinase 3
KAZN kazrin, periplakin interacting protein
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
KIAA1549L KIAA1549-like
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAT linker for activation of T cells
LBR lamin B receptor
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LEP leptin
LEPR leptin receptor
LIG4 ligase IV, DNA, ATP-dependent
MAVS mitochondrial antiviral signaling protein
MMP19 matrix metallopeptidase 19
MSI2 musashi RNA-binding protein 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NBN nibrin
NCKAP1L NCK-associated protein 1-like
NCR1 natural cytotoxicity triggering receptor 1
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
NFE2L2 nuclear factor, erythroid 2-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX2-3 NK2 homeobox 3
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUP98 nucleoporin 98kDa
PAX1 paired box 1
PBX1 pre-B-cell leukemia homeobox 1
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLA2G10 phospholipase A2, group X
PNP purine nucleoside phosphorylase
PRKCH protein kinase C, eta
PRKCQ protein kinase C, theta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPRC protein tyrosine phosphatase, receptor type, C
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RASA3 RAS p21 protein activator 3
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBBP7 retinoblastoma binding protein 7
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RHOH ras homolog family member H
RNASE10 ribonuclease, RNase A family, 10 (non-active)
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RORC RAR-related orphan receptor C
RPL22 ribosomal protein L22
RUNX1 runt-related transcription factor 1
RUVBL2 RuvB-like AAA ATPase 2
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SETMAR SET domain and mariner transposase fusion gene
SGPL1 sphingosine-1-phosphate lyase 1
SH2D1A SH2 domain containing 1A
SHARPIN SHANK-associated RH domain interactor
SHCBP1 SHC SH2-domain binding protein 1
SIRT2 sirtuin 2
SIT1 signaling threshold regulating transmembrane adaptor 1
SP3 Sp3 transcription factor
SPI1 Spi-1 proto-oncogene
SPNS2 spinster homolog 2 (Drosophila)
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK4 serine/threonine kinase 4
SYTL1 synaptotagmin-like 1
TBX21 T-box 21
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TESPA1 thymocyte expressed, positive selection associated 1
TGFB1 transforming growth factor, beta 1
THEMIS thymocyte selection associated
TMEM189 transmembrane protein 189
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TOX thymocyte selection-associated high mobility group box
TP53BP1 tumor protein p53 binding protein 1
VAV1 vav 1 guanine nucleotide exchange factor
WTAP Wilms tumor 1 associated protein
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZBTB1 zinc finger and BTB domain containing 1
ZBTB7B zinc finger and BTB domain containing 7B
ZNF335 zinc finger protein 335