decreased bone mass Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description a reduction in the total amount of bone tissue contained in the skeleton (Mammalian Phenotype Ontology, MP_0004016)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004016
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Genes

69 gene mutations causing the decreased bone mass phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADIPOQ adiponectin, C1Q and collagen domain containing
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase)
ANKRD11 ankyrin repeat domain 11
ARHGAP1 Rho GTPase activating protein 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATR ATR serine/threonine kinase
BGN biglycan
BTD biotinidase
CARTPT CART prepropeptide
CD36 CD36 molecule (thrombospondin receptor)
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CLDN18 claudin 18
CNOT3 CCR4-NOT transcription complex, subunit 3
COL10A1 collagen, type X, alpha 1
COL1A1 collagen, type I, alpha 1
CRTAP cartilage associated protein
CSF1 colony stimulating factor 1 (macrophage)
CTHRC1 collagen triple helix repeat containing 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ERCC2 excision repair cross-complementation group 2
ESR1 estrogen receptor 1
FBN2 fibrillin 2
FHL2 four and a half LIM domains 2
GGT1 gamma-glutamyltransferase 1
GHRHR growth hormone releasing hormone receptor
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
HELLS helicase, lymphoid-specific
IAPP islet amyloid polypeptide
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL10 interleukin 10
IL6ST interleukin 6 signal transducer
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KL klotho
LEP leptin
LMNA lamin A/C
LRP5 low density lipoprotein receptor-related protein 5
LRP6 low density lipoprotein receptor-related protein 6
MCHR1 melanin-concentrating hormone receptor 1
MGP matrix Gla protein
MMP14 matrix metallopeptidase 14 (membrane-inserted)
NCOA1 nuclear receptor coactivator 1
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NLRP3 NLR family, pyrin domain containing 3
PITX3 paired-like homeodomain 3
PKD1 polycystic kidney disease 1 (autosomal dominant)
POLG polymerase (DNA directed), gamma
PPIB peptidylprolyl isomerase B (cyclophilin B)
PRLR prolactin receptor
PTHLH parathyroid hormone-like hormone
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PYY peptide YY
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
SERP1 stress-associated endoplasmic reticulum protein 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SUCO SUN domain containing ossification factor
THRB thyroid hormone receptor, beta
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TOB2 transducer of ERBB2, 2
VCP valosin containing protein
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZDHHC13 zinc finger, DHHC-type containing 13