decreased b cell proliferation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description absent or reduced expansion rate of the B cell population by cell division in response to stimuli (Mammalian Phenotype Ontology, MP_0005093)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005093
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Genes

78 gene mutations causing the decreased b cell proliferation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
BCL10 B-cell CLL/lymphoma 10
BCL2 B-cell CLL/lymphoma 2
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
BLNK B-cell linker
BTK Bruton agammaglobulinemia tyrosine kinase
CARD11 caspase recruitment domain family, member 11
CCND3 cyclin D3
CD19 CD19 molecule
CD22 CD22 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
CD80 CD80 molecule
CD81 CD81 molecule
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DCLRE1C DNA cross-link repair 1C
ERCC1 excision repair cross-complementation group 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FLI1 Fli-1 proto-oncogene, ETS transcription factor
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
HRH1 histamine receptor H1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGHM immunoglobulin heavy constant mu
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL5RA interleukin 5 receptor, alpha
IRAK4 interleukin-1 receptor-associated kinase 4
IRF2 interferon regulatory factor 2
IRF4 interferon regulatory factor 4
LY86 lymphocyte antigen 86
LY96 lymphocyte antigen 96
LYN LYN proto-oncogene, Src family tyrosine kinase
MARK2 MAP/microtubule affinity-regulating kinase 2
MAVS mitochondrial antiviral signaling protein
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYD88 myeloid differentiation primary response 88
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
PARP14 poly (ADP-ribose) polymerase family, member 14
PELI1 pellino E3 ubiquitin protein ligase 1
PGAP3 post-GPI attachment to proteins 3
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PNP purine nucleoside phosphorylase
POU2AF1 POU class 2 associating factor 1
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRKCB protein kinase C, beta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SH3BP2 SH3-domain binding protein 2
SKAP2 src kinase associated phosphoprotein 2
SMAD7 SMAD family member 7
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPPL2A signal peptide peptidase like 2A
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TERC telomerase RNA component
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
UBE2N ubiquitin-conjugating enzyme E2N
UNC93B1 unc-93 homolog B1 (C. elegans)
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
ZEB1 zinc finger E-box binding homeobox 1