decreased anxiety-related response Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests (Mammalian Phenotype Ontology, MP_0001364)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001364
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Genes

84 gene mutations causing the decreased anxiety-related response phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADCY8 adenylate cyclase 8 (brain)
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
ADGRL3 adhesion G protein-coupled receptor L3
AKAP5 A kinase (PRKA) anchor protein 5
ARX aristaless related homeobox
ASPA aspartoacylase
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
AVPR1A arginine vasopressin receptor 1A
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BACE1 beta-site APP-cleaving enzyme 1
C12ORF10 chromosome 12 open reading frame 10
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCKBR cholecystokinin B receptor
CDKL5 cyclin-dependent kinase-like 5
CHL1 cell adhesion molecule L1-like
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CLCN6 chloride channel, voltage-sensitive 6
CNIH1 cornichon family AMPA receptor auxiliary protein 1
CREM cAMP responsive element modulator
CRHR1 corticotropin releasing hormone receptor 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSK c-src tyrosine kinase
DISC1 disrupted in schizophrenia 1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DUSP1 dual specificity phosphatase 1
ELFN1 extracellular leucine-rich repeat and fibronectin type III domain containing 1
FAM3D family with sequence similarity 3, member D
FMR1 fragile X mental retardation 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GABRD gamma-aminobutyric acid (GABA) A receptor, delta
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GPR83 G protein-coupled receptor 83
GRIA1 glutamate receptor, ionotropic, AMPA 1
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GTF2IRD1 GTF2I repeat domain containing 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HRH3 histamine receptor H3
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
IL1R1 interleukin 1 receptor, type I
KALRN kalirin, RhoGEF kinase
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
LPAR5 lysophosphatidic acid receptor 5
LSAMP limbic system-associated membrane protein
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
MAPT microtubule-associated protein tau
MCHR1 melanin-concentrating hormone receptor 1
MECP2 methyl CpG binding protein 2
MMP24 matrix metallopeptidase 24 (membrane-inserted)
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
NPAS3 neuronal PAS domain protein 3
NPY2R neuropeptide Y receptor Y2
OPHN1 oligophrenin 1
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDYN prodynorphin
PITX3 paired-like homeodomain 3
PLAT plasminogen activator, tissue
PRKCG protein kinase C, gamma
PRKCZ protein kinase C, zeta
PSAP prosaposin
PTPRA protein tyrosine phosphatase, receptor type, A
RLN3 relaxin 3
S100A1 S100 calcium binding protein A1
SEPT5 septin 5
SHANK3 SH3 and multiple ankyrin repeat domains 3
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10
STX1A syntaxin 1A (brain)
SYNGAP1 synaptic Ras GTPase activating protein 1
SYNPO synaptopodin
TAC1 tachykinin, precursor 1
TACR1 tachykinin receptor 1
TDO2 tryptophan 2,3-dioxygenase
TLR3 toll-like receptor 3
TNC tenascin C
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TUBA1A tubulin, alpha 1a
WASF1 WAS protein family, member 1