decreased alpha-beta t cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description reduced number of T cells that expresses an alpha-beta T cell receptor complex (Mammalian Phenotype Ontology, MP_0012765)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0012765
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Genes

209 gene mutations causing the decreased alpha-beta t cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACP2 acid phosphatase 2, lysosomal
AP1G1 adaptor-related protein complex 1, gamma 1 subunit
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARID5A AT rich interactive domain 5A (MRF1-like)
ARL4D ADP-ribosylation factor-like 4D
ASXL1 additional sex combs like transcriptional regulator 1
ATM ATM serine/threonine kinase
B2M beta-2-microglobulin
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BATF basic leucine zipper transcription factor, ATF-like
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL2 B-cell CLL/lymphoma 2
BCL6 B-cell CLL/lymphoma 6
BCLAF1 BCL2-associated transcription factor 1
BMF Bcl2 modifying factor
C17ORF62 chromosome 17 open reading frame 62
CADM1 cell adhesion molecule 1
CCL5 chemokine (C-C motif) ligand 5
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CCR6 chemokine (C-C motif) receptor 6
CCR7 chemokine (C-C motif) receptor 7
CD247 CD247 molecule
CD274 CD274 molecule
CD28 CD28 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD4 CD4 molecule
CD5 CD5 molecule
CD69 CD69 molecule
CD70 CD70 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD83 CD83 molecule
CD84 CD84 molecule
CD8A CD8a molecule
CD8B CD8b molecule
CDK6 cyclin-dependent kinase 6
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIITA class II, major histocompatibility complex, transactivator
CLEC10A C-type lectin domain family 10, member A
CORO1A coronin, actin binding protein, 1A
CTSV cathepsin V
CXCL10 chemokine (C-X-C motif) ligand 10
CXCR2 chemokine (C-X-C motif) receptor 2
CYLD cylindromatosis (turban tumor syndrome)
DCK deoxycytidine kinase
DCLRE1C DNA cross-link repair 1C
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DGKZ diacylglycerol kinase, zeta
DIAPH1 diaphanous-related formin 1
DLL1 delta-like 1 (Drosophila)
DOCK2 dedicator of cytokinesis 2
DOCK8 dedicator of cytokinesis 8
EBI3 Epstein-Barr virus induced 3
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAS Fas cell surface death receptor
FBXO7 F-box protein 7
FOXN1 forkhead box N1
FOXP3 forkhead box P3
GCLC glutamate-cysteine ligase, catalytic subunit
GIMAP1-GIMAP5 GIMAP1-GIMAP5 readthrough
GIMAP6 GTPase, IMAP family member 6
GPER1 G protein-coupled estrogen receptor 1
GPR15 G protein-coupled receptor 15
GPR83 G protein-coupled receptor 83
GRAP2 GRB2-related adaptor protein 2
HAX1 HCLS1 associated protein X-1
HCST hematopoietic cell signal transducer
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HLA-A major histocompatibility complex, class I, A
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HNRNPLL heterogeneous nuclear ribonucleoprotein L-like
ICOS inducible T-cell co-stimulator
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFNGR1 interferon gamma receptor 1
IGHM immunoglobulin heavy constant mu
IL13 interleukin 13
IL15 interleukin 15
IL15RA interleukin 15 receptor, alpha
IL17A interleukin 17A
IL17C interleukin 17C
IL2 interleukin 2
IL21 interleukin 21
IL21R interleukin 21 receptor
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
IL4R interleukin 4 receptor
IL5RA interleukin 5 receptor, alpha
IL7R interleukin 7 receptor
IRF1 interferon regulatory factor 1
ITFG2 integrin alpha FG-GAP repeat containing 2
ITGAD integrin, alpha D
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB7 integrin, beta 7
ITK IL2-inducible T-cell kinase
ITPKB inositol-trisphosphate 3-kinase B
JAK3 Janus kinase 3
KAZN kazrin, periplakin interacting protein
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
KIAA1549L KIAA1549-like
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAT linker for activation of T cells
LBR lamin B receptor
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LEP leptin
LEPR leptin receptor
LIG4 ligase IV, DNA, ATP-dependent
LRFN2 leucine rich repeat and fibronectin type III domain containing 2
MAVS mitochondrial antiviral signaling protein
MCL1 myeloid cell leukemia 1
MMP19 matrix metallopeptidase 19
MSI2 musashi RNA-binding protein 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NBN nibrin
NCAPH2 non-SMC condensin II complex, subunit H2
NCKAP1L NCK-associated protein 1-like
NCR1 natural cytotoxicity triggering receptor 1
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
NFE2L2 nuclear factor, erythroid 2-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX2-3 NK2 homeobox 3
NLRC5 NLR family, CARD domain containing 5
NPY1R neuropeptide Y receptor Y1
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUP98 nucleoporin 98kDa
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAX1 paired box 1
PBX1 pre-B-cell leukemia homeobox 1
PDCD1 programmed cell death 1
PDCD1LG2 programmed cell death 1 ligand 2
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLA2G10 phospholipase A2, group X
PNP purine nucleoside phosphorylase
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRKCH protein kinase C, eta
PRKCQ protein kinase C, theta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRSS50 protease, serine, 50
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSMB11 proteasome (prosome, macropain) subunit, beta type, 11
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPRC protein tyrosine phosphatase, receptor type, C
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RASA3 RAS p21 protein activator 3
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBBP7 retinoblastoma binding protein 7
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RHOH ras homolog family member H
RNASE10 ribonuclease, RNase A family, 10 (non-active)
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RORC RAR-related orphan receptor C
RPL22 ribosomal protein L22
RUNX1 runt-related transcription factor 1
RUVBL2 RuvB-like AAA ATPase 2
SAP130 Sin3A-associated protein, 130kDa
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SETMAR SET domain and mariner transposase fusion gene
SGMS1 sphingomyelin synthase 1
SGPL1 sphingosine-1-phosphate lyase 1
SH2D1A SH2 domain containing 1A
SHARPIN SHANK-associated RH domain interactor
SHCBP1 SHC SH2-domain binding protein 1
SIRT1 sirtuin 1
SIRT2 sirtuin 2
SIT1 signaling threshold regulating transmembrane adaptor 1
SP3 Sp3 transcription factor
SPI1 Spi-1 proto-oncogene
SPNS2 spinster homolog 2 (Drosophila)
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
STAT5B signal transducer and activator of transcription 5B
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
STK4 serine/threonine kinase 4
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
SYTL1 synaptotagmin-like 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TAPBP TAP binding protein (tapasin)
TBX21 T-box 21
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TESPA1 thymocyte expressed, positive selection associated 1
TGFB1 transforming growth factor, beta 1
THEMIS thymocyte selection associated
TICAM1 toll-like receptor adaptor molecule 1
TMEM189 transmembrane protein 189
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TOX thymocyte selection-associated high mobility group box
TP53BP1 tumor protein p53 binding protein 1
TPP2 tripeptidyl peptidase II
TXNIP thioredoxin interacting protein
VAV1 vav 1 guanine nucleotide exchange factor
WTAP Wilms tumor 1 associated protein
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZBTB1 zinc finger and BTB domain containing 1
ZBTB7B zinc finger and BTB domain containing 7B
ZEB1 zinc finger E-box binding homeobox 1
ZNF335 zinc finger protein 335