decreased acute inflammation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response (Mammalian Phenotype Ontology, MP_0005087)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005087
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Genes

160 gene mutations causing the decreased acute inflammation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADORA3 adenosine A3 receptor
AHR aryl hydrocarbon receptor
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA5 annexin A5
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
APCS amyloid P component, serum
APOE apolipoprotein E
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BDKRB1 bradykinin receptor B1
BID BH3 interacting domain death agonist
BIRC3 baculoviral IAP repeat containing 3
BTK Bruton agammaglobulinemia tyrosine kinase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCKBR cholecystokinin B receptor
CCL13 chemokine (C-C motif) ligand 13
CCL17 chemokine (C-C motif) ligand 17
CCL3L3 chemokine (C-C motif) ligand 3-like 3
CCL5 chemokine (C-C motif) ligand 5
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CCR4 chemokine (C-C motif) receptor 4
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR6 chemokine (C-C motif) receptor 6
CCR7 chemokine (C-C motif) receptor 7
CCRL2 chemokine (C-C motif) receptor-like 2
CD14 CD14 molecule
CD1D CD1d molecule
CD207 CD207 molecule, langerin
CD28 CD28 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD81 CD81 molecule
CD83 CD83 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CLEC4D C-type lectin domain family 4, member D
CLEC4E C-type lectin domain family 4, member E
CLIC4 chloride intracellular channel 4
CPA3 carboxypeptidase A3 (mast cell)
CREB3L3 cAMP responsive element binding protein 3-like 3
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL6 chemokine (C-X-C motif) ligand 6
CYSLTR1 cysteinyl leukotriene receptor 1
CYSLTR2 cysteinyl leukotriene receptor 2
ECM1 extracellular matrix protein 1
EDNRB endothelin receptor type B
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHB6 EPH receptor B6
F2 coagulation factor II (thrombin)
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FPR2 formyl peptide receptor 2
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
GAB2 GRB2-associated binding protein 2
GCA grancalcin, EF-hand calcium binding protein
GGT5 gamma-glutamyltransferase 5
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
HLA-DMA major histocompatibility complex, class II, DM alpha
ICAM1 intercellular adhesion molecule 1
IDO1 indoleamine 2,3-dioxygenase 1
IDO2 indoleamine 2,3-dioxygenase 2
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IGHM immunoglobulin heavy constant mu
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL12A interleukin 12A
IL12B interleukin 12B
IL13RA2 interleukin 13 receptor, alpha 2
IL15 interleukin 15
IL17A interleukin 17A
IL17F interleukin 17F
IL18 interleukin 18
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL21R interleukin 21 receptor
IL3 interleukin 3
IL33 interleukin 33
IL34 interleukin 34
IRAK2 interleukin-1 receptor-associated kinase 2
IRAK4 interleukin-1 receptor-associated kinase 4
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LBP lipopolysaccharide binding protein
LITAF lipopolysaccharide-induced TNF factor
LTA lymphotoxin alpha
LTA4H leukotriene A4 hydrolase
LTB4R leukotriene B4 receptor
LTB4R2 leukotriene B4 receptor 2
LTC4S leukotriene C4 synthase
LY96 lymphocyte antigen 96
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MMP19 matrix metallopeptidase 19
MMP3 matrix metallopeptidase 3
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NLRP10 NLR family, pyrin domain containing 10
NLRP12 NLR family, pyrin domain containing 12
NLRP3 NLR family, pyrin domain containing 3
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NPY1R neuropeptide Y receptor Y1
NR1H3 nuclear receptor subfamily 1, group H, member 3
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
ORAI1 ORAI calcium release-activated calcium modulator 1
PARP1 poly (ADP-ribose) polymerase 1
PELI1 pellino E3 ubiquitin protein ligase 1
PGF placental growth factor
PLA2G3 phospholipase A2, group III
PLA2G5 phospholipase A2, group V
PLA2R1 phospholipase A2 receptor 1, 180kDa
PTGDR prostaglandin D2 receptor (DP)
PTGDR2 prostaglandin D2 receptor 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2B protein tyrosine kinase 2 beta
PTPRC protein tyrosine phosphatase, receptor type, C
PYCARD PYD and CARD domain containing
RAG2 recombination activating gene 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOH ras homolog family member H
S100A9 S100 calcium binding protein A9
S1PR3 sphingosine-1-phosphate receptor 3
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SPHK1 sphingosine kinase 1
SPP1 secreted phosphoprotein 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STIM1 stromal interaction molecule 1
STXBP2 syntaxin binding protein 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TERF2IP telomeric repeat binding factor 2, interacting protein
TGM2 transglutaminase 2
TICAM1 toll-like receptor adaptor molecule 1
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRADD TNFRSF1A-associated via death domain
TRIP10 thyroid hormone receptor interactor 10
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSLP thymic stromal lymphopoietin
TYROBP TYRO protein tyrosine kinase binding protein
UBE2N ubiquitin-conjugating enzyme E2N
VIPR2 vasoactive intestinal peptide receptor 2