dantrolene-2369 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

193 genes differentially expressed following the dantrolene-2369 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD6 abhydrolase domain containing 6
ACSBG2 acyl-CoA synthetase bubblegum family member 2
AGXT alanine-glyoxylate aminotransferase
APOA4 apolipoprotein A-IV
APOL3 apolipoprotein L, 3
C9ORF9 chromosome 9 open reading frame 9
CAV2 caveolin 2
CCRL2 chemokine (C-C motif) receptor-like 2
CD3D CD3d molecule, delta (CD3-TCR complex)
CD52 CD52 molecule
CD70 CD70 molecule
CDK20 cyclin-dependent kinase 20
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CFHR4 complement factor H-related 4
CLDN17 claudin 17
COL6A1 collagen, type VI, alpha 1
COL9A1 collagen, type IX, alpha 1
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CSRP2 cysteine and glycine-rich protein 2
CXXC4 CXXC finger protein 4
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
DGCR8 DGCR8 microprocessor complex subunit
DTX2P1-UPK3BP1-PMS2P11 DTX2P1-UPK3BP1-PMS2P11 readthrough transcribed pseudogene
EDNRB endothelin receptor type B
EGR1 early growth response 1
ELL2 elongation factor, RNA polymerase II, 2
EML2 echinoderm microtubule associated protein like 2
EMX1 empty spiracles homeobox 1
EPYC epiphycan
EYA3 EYA transcriptional coactivator and phosphatase 3
FBP1 fructose-1,6-bisphosphatase 1
FGF4 fibroblast growth factor 4
FOXN3 forkhead box N3
FRMD4B FERM domain containing 4B
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GIP gastric inhibitory polypeptide
GNAS GNAS complex locus
GRIP2 glutamate receptor interacting protein 2
HEYL hes-related family bHLH transcription factor with YRPW motif-like
HN1L hematological and neurological expressed 1-like
HOXA10 homeobox A10
IL12B interleukin 12B
IL18RAP interleukin 18 receptor accessory protein
IL4R interleukin 4 receptor
IL5RA interleukin 5 receptor, alpha
INO80D INO80 complex subunit D
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
LAMA2 laminin, alpha 2
LINC00597 long intergenic non-protein coding RNA 597
LNPEP leucyl/cystinyl aminopeptidase
LOXL3 lysyl oxidase-like 3
LTB lymphotoxin beta (TNF superfamily, member 3)
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MARK4 MAP/microtubule affinity-regulating kinase 4
MIA melanoma inhibitory activity
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MTMR3 myotubularin related protein 3
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NNAT neuronatin
PCSK6 proprotein convertase subtilisin/kexin type 6
PDE12 phosphodiesterase 12
PEG3 paternally expressed 3
PICALM phosphatidylinositol binding clathrin assembly protein
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLCH1 phospholipase C, eta 1
PLXDC1 plexin domain containing 1
PMFBP1 polyamine modulated factor 1 binding protein 1
PVR poliovirus receptor
RNF40 ring finger protein 40, E3 ubiquitin protein ligase
RPH3A rabphilin 3A
RYK receptor-like tyrosine kinase
S100A13 S100 calcium binding protein A13
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SETD8 SET domain containing (lysine methyltransferase) 8
SFTPB surfactant protein B
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNTA1 syntrophin, alpha 1
SPHK2 sphingosine kinase 2
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
SSH3 slingshot protein phosphatase 3
STEAP4 STEAP family member 4
STYK1 serine/threonine/tyrosine kinase 1
TADA2A transcriptional adaptor 2A
TAT tyrosine aminotransferase
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TCTA T-cell leukemia translocation altered
TEF thyrotrophic embryonic factor
TEK TEK tyrosine kinase, endothelial
TJAP1 tight junction associated protein 1 (peripheral)
TMEM40 transmembrane protein 40
TPMT thiopurine S-methyltransferase
UBXN1 UBX domain protein 1
ZNF510 zinc finger protein 510
ZNF783 zinc finger family member 783
ZNF814 zinc finger protein 814
ZNF93 zinc finger protein 93

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
AACS acetoacetyl-CoA synthetase
ABHD4 abhydrolase domain containing 4
ACPP acid phosphatase, prostate
ACSL4 acyl-CoA synthetase long-chain family member 4
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ANKRD36 ankyrin repeat domain 36
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
APH1B APH1B gamma secretase subunit
ARHGAP12 Rho GTPase activating protein 12
ASAP1-IT1 ASAP1 intronic transcript 1
ATAD5 ATPase family, AAA domain containing 5
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BATF basic leucine zipper transcription factor, ATF-like
BCL7C B-cell CLL/lymphoma 7C
BIK BCL2-interacting killer (apoptosis-inducing)
BOLA1 bolA family member 1
C11ORF68 chromosome 11 open reading frame 68
C2CD2 C2 calcium-dependent domain containing 2
C3 complement component 3
CALCOCO1 calcium binding and coiled-coil domain 1
CASP7 caspase 7, apoptosis-related cysteine peptidase
CEP70 centrosomal protein 70kDa
CHKB choline kinase beta
COPS7B COP9 signalosome subunit 7B
CPTP ceramide-1-phosphate transfer protein
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CSF1R colony stimulating factor 1 receptor
DAAM1 dishevelled associated activator of morphogenesis 1
EDAR ectodysplasin A receptor
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ETAA1 Ewing tumor-associated antigen 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM53B family with sequence similarity 53, member B
FKBPL FK506 binding protein like
GAB2 GRB2-associated binding protein 2
GPR22 G protein-coupled receptor 22
HIST1H2BE histone cluster 1, H2be
HIST1H4J histone cluster 1, H4j
HYAL3 hyaluronoglucosaminidase 3
IL2RG interleukin 2 receptor, gamma
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
IREB2 iron-responsive element binding protein 2
ITPKB inositol-trisphosphate 3-kinase B
KCNK5 potassium channel, two pore domain subfamily K, member 5
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
KIF3B kinesin family member 3B
MAGEB2 melanoma antigen family B2
MANEA mannosidase, endo-alpha
MECR mitochondrial trans-2-enoyl-CoA reductase
METTL16 methyltransferase like 16
MICA MHC class I polypeptide-related sequence A
MPDU1 mannose-P-dolichol utilization defect 1
MRPL52 mitochondrial ribosomal protein L52
MYL5 myosin, light chain 5, regulatory
NCS1 neuronal calcium sensor 1
NIPAL2 NIPA-like domain containing 2
NOD1 nucleotide-binding oligomerization domain containing 1
NTSR1 neurotensin receptor 1 (high affinity)
PARG poly (ADP-ribose) glycohydrolase
PBX3 pre-B-cell leukemia homeobox 3
POMT1 protein-O-mannosyltransferase 1
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PTCD1 pentatricopeptide repeat domain 1
PTPN9 protein tyrosine phosphatase, non-receptor type 9
RAD9A RAD9 homolog A (S. pombe)
RFXAP regulatory factor X-associated protein
RINT1 RAD50 interactor 1
RP2 retinitis pigmentosa 2 (X-linked recessive)
SCRIB scribbled planar cell polarity protein
SEPW1 selenoprotein W, 1
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SMR3A submaxillary gland androgen regulated protein 3A
SPATA7 spermatogenesis associated 7
SRD5A3 steroid 5 alpha-reductase 3
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
SYNJ2BP synaptojanin 2 binding protein
TASP1 taspase, threonine aspartase, 1
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM254 transmembrane protein 254
TRAPPC13 trafficking protein particle complex 13
TTC33 tetratricopeptide repeat domain 33
UBXN8 UBX domain protein 8
XAB2 XPA binding protein 2
XYLT1 xylosyltransferase I
YPEL5 yippee-like 5 (Drosophila)
ZBTB44 zinc finger and BTB domain containing 44
ZNF37BP zinc finger protein 37B, pseudogene
ZNF529 zinc finger protein 529
ZNF552 zinc finger protein 552
ZNF654 zinc finger protein 654