cytotoxic Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Similar Terms
Downloads & Tools

Genes

403 genes co-occuring with the biological term cytotoxic in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADGRG1 adhesion G protein-coupled receptor G1
ADIPOQ adiponectin, C1Q and collagen domain containing
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALCAM activated leukocyte cell adhesion molecule
ALK anaplastic lymphoma receptor tyrosine kinase
ALPP alkaline phosphatase, placental
AMER1 APC membrane recruitment protein 1
AMH anti-Mullerian hormone
APC adenomatous polyposis coli
APOL2 apolipoprotein L, 2
APP amyloid beta (A4) precursor protein
AQP3 aquaporin 3 (Gill blood group)
ARRB2 arrestin, beta 2
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATG5 autophagy related 5
ATMIN ATM interactor
ATR ATR serine/threonine kinase
B3GAT1 beta-1,3-glucuronyltransferase 1
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BDNF brain-derived neurotrophic factor
BECN1 beclin 1, autophagy related
BPI bactericidal/permeability-increasing protein
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BST2 bone marrow stromal cell antigen 2
BTK Bruton agammaglobulinemia tyrosine kinase
BTLA B and T lymphocyte associated
C1QBP complement component 1, q subcomponent binding protein
CALCA calcitonin-related polypeptide alpha
CALR calreticulin
CAMP cathelicidin antimicrobial peptide
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASR calcium-sensing receptor
CCL17 chemokine (C-C motif) ligand 17
CCL2 chemokine (C-C motif) ligand 2
CCL21 chemokine (C-C motif) ligand 21
CCL5 chemokine (C-C motif) ligand 5
CCND1 cyclin D1
CCND2 cyclin D2
CCR2 chemokine (C-C motif) receptor 2
CCR4 chemokine (C-C motif) receptor 4
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD160 CD160 molecule
CD244 CD244 molecule, natural killer cell receptor 2B4
CD27 CD27 molecule
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD4 CD4 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD70 CD70 molecule
CD80 CD80 molecule
CD86 CD86 molecule
CD8A CD8a molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDR2 cerebellar degeneration-related protein 2, 62kDa
CFLAR CASP8 and FADD-like apoptosis regulator
CHEK1 checkpoint kinase 1
CLDN3 claudin 3
CLDN4 claudin 4
CLEC12A C-type lectin domain family 12, member A
CLEC4C C-type lectin domain family 4, member C
CLEC7A C-type lectin domain family 7, member A
CLEC9A C-type lectin domain family 9, member A
CLU clusterin
CORO1A coronin, actin binding protein, 1A
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CST3 cystatin C
CTAG1B cancer/testis antigen 1B
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSB cathepsin B
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR4 chemokine (C-X-C motif) receptor 4
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1
D6S207E Minor histocompatibility antigen HA-2
DMD dystrophin
DNM1 dynamin 1
DUSP6 dual specificity phosphatase 6
DVL1 dishevelled segment polarity protein 1
DYSF dysferlin
E2F1 E2F transcription factor 1
EDNRA endothelin receptor type A
EFHD2 EF-hand domain family, member D2
EGF epidermal growth factor
EGFR epidermal growth factor receptor
ELANE elastase, neutrophil expressed
ELAVL4 ELAV like neuron-specific RNA binding protein 4
EML4 echinoderm microtubule associated protein like 4
EMP2 epithelial membrane protein 2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
ERCC1 excision repair cross-complementation group 1
ERCC3 excision repair cross-complementation group 3
ETV4 ets variant 4
ETV6 ets variant 6
FAIM Fas apoptotic inhibitory molecule
FAP fibroblast activation protein, alpha
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FCRL6 Fc receptor-like 6
FERMT3 fermitin family member 3
FLT3 fms-related tyrosine kinase 3
FOXM1 forkhead box M1
FOXP3 forkhead box P3
FTO fat mass and obesity associated
GCG glucagon
GDI1 GDP dissociation inhibitor 1
GDNF glial cell derived neurotrophic factor
GJA1 gap junction protein, alpha 1, 43kDa
GNLY granulysin
GNMT glycine N-methyltransferase
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GSTP1 glutathione S-transferase pi 1
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
GZMK granzyme K (granzyme 3; tryptase II)
HAVCR2 hepatitis A virus cellular receptor 2
HCST hematopoietic cell signal transducer
HDAC10 histone deacetylase 10
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HFE hemochromatosis
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-E major histocompatibility complex, class I, E
HMGB2 high mobility group box 2
HMHA1 histocompatibility (minor) HA-1
HMOX1 heme oxygenase 1
HNRNPK heterogeneous nuclear ribonucleoprotein K
HSBP1 heat shock factor binding protein 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA2 heat shock 70kDa protein 2
HSPA4 heat shock 70kDa protein 4
HSPB1 heat shock 27kDa protein 1
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
HTT huntingtin
HYOU1 hypoxia up-regulated 1
IAPP islet amyloid polypeptide
ICAM1 intercellular adhesion molecule 1
ICOS inducible T-cell co-stimulator
IDE insulin-degrading enzyme
IDO1 indoleamine 2,3-dioxygenase 1
IDO2 indoleamine 2,3-dioxygenase 2
IFN1@ interferon, type 1, cluster
IFNA1 interferon, alpha 1
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IGF1R insulin-like growth factor 1 receptor
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGH immunoglobulin heavy locus
IL10 interleukin 10
IL12A interleukin 12A
IL12B interleukin 12B
IL13 interleukin 13
IL15 interleukin 15
IL18 interleukin 18
IL1B interleukin 1, beta
IL2 interleukin 2
IL21 interleukin 21
IL27 interleukin 27
IL2RA interleukin 2 receptor, alpha
IL2RG interleukin 2 receptor, gamma
IL32 interleukin 32
IL4 interleukin 4
IL4R interleukin 4 receptor
IL7 interleukin 7
IL7R interleukin 7 receptor
IRF4 interferon regulatory factor 4
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB4 integrin, beta 4
ITGB7 integrin, beta 7
JAK2 Janus kinase 2
JUN jun proto-oncogene
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KDR kinase insert domain receptor
KEAP1 kelch-like ECH-associated protein 1
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2
KITLG KIT ligand
KLK3 kallikrein-related peptidase 3
KLK4 kallikrein-related peptidase 4
KLRC1 killer cell lectin-like receptor subfamily C, member 1
KLRC2 killer cell lectin-like receptor subfamily C, member 2
KLRD1 killer cell lectin-like receptor subfamily D, member 1
KLRK1 killer cell lectin-like receptor subfamily K, member 1
KRT8 keratin 8, type II
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAMP1 lysosomal-associated membrane protein 1
LCK LCK proto-oncogene, Src family tyrosine kinase
LEP leptin
LGALS9 lectin, galactoside-binding, soluble, 9
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
LPL lipoprotein lipase
LRP1 low density lipoprotein receptor-related protein 1
LY6K lymphocyte antigen 6 complex, locus K
LYST lysosomal trafficking regulator
MAGEC2 melanoma antigen family C2
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MCL1 myeloid cell leukemia 1
MET MET proto-oncogene, receptor tyrosine kinase
MGMT O-6-methylguanine-DNA methyltransferase
MICA MHC class I polypeptide-related sequence A
MICB MHC class I polypeptide-related sequence B
MIR155 microRNA 155
MIR210 microRNA 210
MLANA melan-A
MME membrane metallo-endopeptidase
MPO myeloperoxidase
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSH3 mutS homolog 3
MSLN mesothelin
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC1 mucin 1, cell surface associated
MUC16 mucin 16, cell surface associated
MYB v-myb avian myeloblastosis viral oncogene homolog
MYOD1 myogenic differentiation 1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAM1 neural cell adhesion molecule 1
NCR1 natural cytotoxicity triggering receptor 1
NCR3 natural cytotoxicity triggering receptor 3
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NGF nerve growth factor (beta polypeptide)
NGFR nerve growth factor receptor
NOS2 nitric oxide synthase 2, inducible
NOTCH1 notch 1
NOTCH2 notch 2
NOX4 NADPH oxidase 4
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NRD1 nardilysin (N-arginine dibasic convertase)
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
PARP1 poly (ADP-ribose) polymerase 1
PARVA parvin, alpha
PDCD1 programmed cell death 1
PDF peptide deformylase (mitochondrial)
PECAM1 platelet/endothelial cell adhesion molecule 1
PGLYRP1 peptidoglycan recognition protein 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLAC1 placenta-specific 1
PNLIPRP2 pancreatic lipase-related protein 2
POMC proopiomelanocortin
PON1 paraoxonase 1
POU1F1 POU class 1 homeobox 1
PPARG peroxisome proliferator-activated receptor gamma
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PRAME preferentially expressed antigen in melanoma
PRDM1 PR domain containing 1, with ZNF domain
PRDX5 peroxiredoxin 5
PRF1 perforin 1 (pore forming protein)
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKCD protein kinase C, delta
PRNP prion protein
PRTN3 proteinase 3
PSCA prostate stem cell antigen
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTHLH parathyroid hormone-like hormone
RAB27A RAB27A, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAD51 RAD51 recombinase
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RB1 retinoblastoma 1
RCAN1 regulator of calcineurin 1
RHOA ras homolog family member A
RNASE3 ribonuclease, RNase A family, 3
ROPN1 rhophilin associated tail protein 1
RPA1 replication protein A1, 70kDa
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RREB1 ras responsive element binding protein 1
RRM1 ribonucleotide reductase M1
RUNX1 runt-related transcription factor 1
S100A9 S100 calcium binding protein A9
SCFV single-chain Fv fragment
SCG5 secretogranin V
SCGB2A2 secretoglobin, family 2A, member 2
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SET SET nuclear proto-oncogene
SH2D1A SH2 domain containing 1A
SIGLEC8 sialic acid binding Ig-like lectin 8
SIGLEC9 sialic acid binding Ig-like lectin 9
SLAMF6 SLAM family member 6
SLAMF7 SLAM family member 7
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNAI1 snail family zinc finger 1
SNAR-E small ILF3/NF90-associated RNA E
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOD1 superoxide dismutase 1, soluble
SPA17 sperm autoantigenic protein 17
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SREBF1 sterol regulatory element binding transcription factor 1
SRGN serglycin
ST18 suppression of tumorigenicity 18, zinc finger
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STX11 syntaxin 11
STX7 syntaxin 7
STXBP2 syntaxin binding protein 2
T T, brachyury homolog (mouse)
TAC1 tachykinin, precursor 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TBX21 T-box 21
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TERT telomerase reverse transcriptase
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
THOP1 thimet oligopeptidase 1
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR7 toll-like receptor 7
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TP53 tumor protein p53
TPBG trophoblast glycoprotein
TPMT thiopurine S-methyltransferase
TRADD TNFRSF1A-associated via death domain
TRD T cell receptor delta locus
TRG T cell receptor gamma locus
TRIB3 tribbles pseudokinase 3
TRIM5 tripartite motif containing 5
TTK TTK protein kinase
TTR transthyretin
TUBB3 tubulin, beta 3 class III
TXNRD1 thioredoxin reductase 1
TYMP thymidine phosphorylase
UBB ubiquitin B
ULBP1 UL16 binding protein 1
ULBP3 UL16 binding protein 3
UNC13B unc-13 homolog B (C. elegans)
UNC13D unc-13 homolog D (C. elegans)
VDAC1 voltage-dependent anion channel 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WIPF1 WAS/WASL interacting protein family, member 1
WISP1 WNT1 inducible signaling pathway protein 1
WT1 Wilms tumor 1
XAF1 XIAP associated factor 1
XBP1 X-box binding protein 1
YBX1 Y box binding protein 1
YBX3 Y box binding protein 3
YY1 YY1 transcription factor
ZNF395 zinc finger protein 395