cytotoxic T-lymphocyte Gene Set

Dataset ProteomicsDB Cell Type and Tissue Protein Expression Profiles
Category proteomics
Type cell type or tissue
Description Subset of T-lymphocytes (mostly CD8+) responsible for lysing target cells and for killing virus-infected cells. (BRENDA Tissue and Enzyme Source Ontology, BTO_0000289)
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Genes

274 proteins with high or low expression in cytotoxic T-lymphocyte relative to other cell types and tissues from the ProteomicsDB Cell Type and Tissue Protein Expression Profiles dataset.

high expression

Symbol Name Standardized Value
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 1.98781
OSTF1 osteoclast stimulating factor 1 1.8989
VTI1B vesicle transport through interaction with t-SNAREs 1B 1.72055
SEPT6 septin 6 1.69032
MYH9 myosin, heavy chain 9, non-muscle 1.65287
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 1.62654
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 1.60232
FAM49B family with sequence similarity 49, member B 1.59241
WDR1 WD repeat domain 1 1.56684
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 1.55596
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1 1.54885
ARPC5L actin related protein 2/3 complex, subunit 5-like 1.53682
LDHB lactate dehydrogenase B 1.52406
HMGB1 high mobility group box 1 1.51062
SAMHD1 SAM domain and HD domain 1 1.50651
PRCP prolylcarboxypeptidase (angiotensinase C) 1.47034
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 1.46786
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.44929
C9ORF142 chromosome 9 open reading frame 142 1.40993
DNM2 dynamin 2 1.38149
ARPC4-TTLL3 ARPC4-TTLL3 readthrough 1.37107
TPM3 tropomyosin 3 1.37057
PPP1R8 protein phosphatase 1, regulatory subunit 8 1.35665
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.34896
H2AFY H2A histone family, member Y 1.31365
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 1.31225
TMSB4X thymosin beta 4, X-linked 1.30848
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) 1.29422
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 1.28296
PPIL3 peptidylprolyl isomerase (cyclophilin)-like 3 1.27885
CAPZB capping protein (actin filament) muscle Z-line, beta 1.27069
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 1.25922
STAT1 signal transducer and activator of transcription 1, 91kDa 1.25855
STK38 serine/threonine kinase 38 1.2566
APRT adenine phosphoribosyltransferase 1.22992
ANXA6 annexin A6 1.22512
SLTM SAFB-like, transcription modulator 1.22248
CGGBP1 CGG triplet repeat binding protein 1 1.21135
RHOG ras homolog family member G 1.20542
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 1.19118
PPP4R2 protein phosphatase 4, regulatory subunit 2 1.18964
NCK1 NCK adaptor protein 1 1.18613
C19ORF43 chromosome 19 open reading frame 43 1.17776
ESYT1 extended synaptotagmin-like protein 1 1.16754
CRLF3 cytokine receptor-like factor 3 1.1613
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa 1.1602
HMGB2 high mobility group box 2 1.15694
EFHD2 EF-hand domain family, member D2 1.15528
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 1.15139
LMNB2 lamin B2 1.149
YY1 YY1 transcription factor 1.14071
SYNE2 spectrin repeat containing, nuclear envelope 2 1.13827
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1 1.13807
CHMP4A charged multivesicular body protein 4A 1.13424
PPIA peptidylprolyl isomerase A (cyclophilin A) 1.12943
GSTK1 glutathione S-transferase kappa 1 1.12783
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 1.12493
RIC8A RIC8 guanine nucleotide exchange factor A 1.10552
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H') 1.10497
ANXA1 annexin A1 1.10158
LMNB1 lamin B1 1.09681
CCAR2 cell cycle and apoptosis regulator 2 1.09622
USP5 ubiquitin specific peptidase 5 (isopeptidase T) 1.08479
LOC102724023 ES1 protein homolog, mitochondrial 1.0825
HP1BP3 heterochromatin protein 1, binding protein 3 1.08043
HIST4H4 histone cluster 4, H4 1.07459
CORO7-PAM16 CORO7-PAM16 readthrough 1.07425
BCL2L13 BCL2-like 13 (apoptosis facilitator) 1.06857
MAVS mitochondrial antiviral signaling protein 1.06784
MAP2K3 mitogen-activated protein kinase kinase 3 1.06663
PGM2 phosphoglucomutase 2 1.05296
CWF19L1 CWF19-like 1, cell cycle control (S. pombe) 1.05175
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 1.04789
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 1.038
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 1.03766
CAPNS1 calpain, small subunit 1 1.03126
RAB11B RAB11B, member RAS oncogene family 1.02712
SH3BP1 SH3-domain binding protein 1 1.02299
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) 1.02107
ESYT2 extended synaptotagmin-like protein 2 1.02027
TRIP4 thyroid hormone receptor interactor 4 1.01342
ITSN2 intersectin 2 1.00978
RAB8A RAB8A, member RAS oncogene family 1.00522
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 1.00372
SNRPB2 small nuclear ribonucleoprotein polypeptide B 0.991945
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.988266
EHD1 EH-domain containing 1 0.987621
CFL1 cofilin 1 (non-muscle) 0.984597
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.973513
CTBP1 C-terminal binding protein 1 0.973312
PANK4 pantothenate kinase 4 0.971616
PDCD10 programmed cell death 10 0.970002
KIF2A kinesin heavy chain member 2A 0.968051
METTL3 methyltransferase like 3 0.964739
CHMP1A charged multivesicular body protein 1A 0.963965
WDR5 WD repeat domain 5 0.96374
INTS7 integrator complex subunit 7 0.963481
SART1 squamous cell carcinoma antigen recognized by T cells 0.96238
OXSR1 oxidative stress responsive 1 0.954603
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) 0.953971
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.951857
USMG5 up-regulated during skeletal muscle growth 5 homolog (mouse) 0.944251
NELFB negative elongation factor complex member B 0.943215
CNN2 calponin 2 0.942448
ACTB actin, beta 0.937898
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 0.916211
PTBP3 polypyrimidine tract binding protein 3 0.914543
DBNL drebrin-like 0.910746
NAE1 NEDD8 activating enzyme E1 subunit 1 0.910742
STK10 serine/threonine kinase 10 0.907075
BRCC3 BRCA1/BRCA2-containing complex, subunit 3 0.904263
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 0.903264
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 0.902974
LASP1 LIM and SH3 protein 1 0.901975
GATAD2B GATA zinc finger domain containing 2B 0.899679
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 0.897905
IQGAP1 IQ motif containing GTPase activating protein 1 0.887424
SPAG7 sperm associated antigen 7 0.880267
NUP62 nucleoporin 62kDa 0.87875
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 0.868208
ADD1 adducin 1 (alpha) 0.866938
ABRACL ABRA C-terminal like 0.866863
MDH1 malate dehydrogenase 1, NAD (soluble) 0.86535
OSGEP O-sialoglycoprotein endopeptidase 0.864637
TWF2 twinfilin actin binding protein 2 0.855057
VIM vimentin 0.85402
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.844718
TOR1AIP1 torsin A interacting protein 1 0.839079
TLN1 talin 1 0.83646
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 0.833502
HDDC2 HD domain containing 2 0.826634
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.826207
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 0.825125

low expression

Symbol Name Standardized Value
ACACA acetyl-CoA carboxylase alpha -2.48431
MGST1 microsomal glutathione S-transferase 1 -2.46141
CALU calumenin -2.22066
RAB5C RAB5C, member RAS oncogene family -2.18332
HMBS hydroxymethylbilane synthase -2.10467
CORO1B coronin, actin binding protein, 1B -2.0841
CLIC4 chloride intracellular channel 4 -2.07223
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -2.0264
TFRC transferrin receptor -1.87969
ATOX1 antioxidant 1 copper chaperone -1.85409
CD59 CD59 molecule, complement regulatory protein -1.81258
MRPS6 mitochondrial ribosomal protein S6 -1.77423
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -1.74897
COX17 COX17 cytochrome c oxidase copper chaperone -1.74869
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) -1.73877
HSPB1 heat shock 27kDa protein 1 -1.7164
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -1.69116
CTTN cortactin -1.65495
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 -1.65117
CRK v-crk avian sarcoma virus CT10 oncogene homolog -1.63867
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -1.63689
EMC4 ER membrane protein complex subunit 4 -1.63685
PYCR2 pyrroline-5-carboxylate reductase family, member 2 -1.6256
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -1.58306
PDIA5 protein disulfide isomerase family A, member 5 -1.58232
ADI1 acireductone dioxygenase 1 -1.55433
NMD3 NMD3 ribosome export adaptor -1.54707
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -1.49139
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 -1.48952
PKN2 protein kinase N2 -1.44675
HDLBP high density lipoprotein binding protein -1.4143
SYNJ2BP synaptojanin 2 binding protein -1.3988
NPTN neuroplastin -1.38686
RTN3 reticulon 3 -1.38527
ANKRD17 ankyrin repeat domain 17 -1.38419
ACSL3 acyl-CoA synthetase long-chain family member 3 -1.37396
POFUT1 protein O-fucosyltransferase 1 -1.36329
RHEB Ras homolog enriched in brain -1.34948
C1ORF27 chromosome 1 open reading frame 27 -1.34411
VAV2 vav 2 guanine nucleotide exchange factor -1.3374
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -1.33515
PRKCI protein kinase C, iota -1.33372
DYNLRB1 dynein, light chain, roadblock-type 1 -1.33204
ASPH aspartate beta-hydroxylase -1.30272
RCN1 reticulocalbin 1, EF-hand calcium binding domain -1.28666
RPS27A ribosomal protein S27a -1.28444
TUBB6 tubulin, beta 6 class V -1.27647
TBCE tubulin folding cofactor E -1.26783
DCTD dCMP deaminase -1.25784
NCAPD2 non-SMC condensin I complex, subunit D2 -1.23331
FAM3C family with sequence similarity 3, member C -1.21737
ACOX1 acyl-CoA oxidase 1, palmitoyl -1.20634
PSPH phosphoserine phosphatase -1.20214
SCRN1 secernin 1 -1.20069
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -1.19926
PSAP prosaposin -1.19462
COA6 cytochrome c oxidase assembly factor 6 -1.19165
PFKM phosphofructokinase, muscle -1.18985
L2HGDH L-2-hydroxyglutarate dehydrogenase -1.18396
PTRH2 peptidyl-tRNA hydrolase 2 -1.1819
COMT catechol-O-methyltransferase -1.17547
MYO1C myosin IC -1.15585
TST thiosulfate sulfurtransferase (rhodanese) -1.14266
NHLRC2 NHL repeat containing 2 -1.14264
IDI1 isopentenyl-diphosphate delta isomerase 1 -1.13392
SQSTM1 sequestosome 1 -1.11768
NSDHL NAD(P) dependent steroid dehydrogenase-like -1.11622
MAPK15 mitogen-activated protein kinase 15 -1.11236
STX12 syntaxin 12 -1.09432
AAR2 AAR2 splicing factor homolog (S. cerevisiae) -1.08389
PFN2 profilin 2 -1.07992
HSP90AB2P heat shock protein 90kDa alpha (cytosolic), class B member 2, pseudogene -1.0784
TM9SF2 transmembrane 9 superfamily member 2 -1.07092
CYFIP1 cytoplasmic FMR1 interacting protein 1 -1.07059
SRP19 signal recognition particle 19kDa -1.06
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -1.05276
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F -1.04925
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum) -1.04616
UGDH UDP-glucose 6-dehydrogenase -1.03994
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C -1.03899
UBE2H ubiquitin-conjugating enzyme E2H -1.03475
PLXNB2 plexin B2 -1.03185
ARL1 ADP-ribosylation factor-like 1 -1.02334
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) -1.02286
FSCN1 fascin actin-bundling protein 1 -1.01571
MCFD2 multiple coagulation factor deficiency 2 -1.01334
NAMPT nicotinamide phosphoribosyltransferase -1.01044
PFDN6 prefoldin subunit 6 -1.00505
NPEPPS aminopeptidase puromycin sensitive -1.00486
MRPS10 mitochondrial ribosomal protein S10 -0.992884
SKP1 S-phase kinase-associated protein 1 -0.988518
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) -0.988227
DUSP3 dual specificity phosphatase 3 -0.981554
TBL2 transducin (beta)-like 2 -0.981402
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.980361
ACLY ATP citrate lyase -0.97787
TPM2 tropomyosin 2 (beta) -0.977832
HCCS holocytochrome c synthase -0.973323
ANKRD28 ankyrin repeat domain 28 -0.972923
PGRMC1 progesterone receptor membrane component 1 -0.956288
RDX radixin -0.935557
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) -0.933194
LIMA1 LIM domain and actin binding 1 -0.932973
FABP5 fatty acid binding protein 5 (psoriasis-associated) -0.932275
INF2 inverted formin, FH2 and WH2 domain containing -0.932086
TELO2 telomere maintenance 2 -0.928191
RETSAT retinol saturase (all-trans-retinol 13,14-reductase) -0.924372
PTMS parathymosin -0.92248
DLD dihydrolipoamide dehydrogenase -0.921305
WDR77 WD repeat domain 77 -0.919256
CNPY2 canopy FGF signaling regulator 2 -0.918647
PHGDH phosphoglycerate dehydrogenase -0.917789
TPM1 tropomyosin 1 (alpha) -0.917406
PFDN1 prefoldin subunit 1 -0.91434
CUX1 cut-like homeobox 1 -0.912634
SEC24D SEC24 family member D -0.912071
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form) -0.910316
DSTN destrin (actin depolymerizing factor) -0.907707
RRM1 ribonucleotide reductase M1 -0.905518
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.904643
JUP junction plakoglobin -0.896843
MRPS35 mitochondrial ribosomal protein S35 -0.894125
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) -0.893683
FASN fatty acid synthase -0.884542
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -0.882476
EXOC5 exocyst complex component 5 -0.877345
PGD phosphogluconate dehydrogenase -0.877049
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.875977
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.873708
VKORC1L1 vitamin K epoxide reductase complex, subunit 1-like 1 -0.873682
C20ORF27 chromosome 20 open reading frame 27 -0.86311
HSPA13 heat shock protein 70kDa family, member 13 -0.855614
GCSH glycine cleavage system protein H (aminomethyl carrier) -0.855297
DNAAF5 dynein, axonemal, assembly factor 5 -0.851986
COLGALT1 collagen beta(1-O)galactosyltransferase 1 -0.850758
HMGB3 high mobility group box 3 -0.848261
SCARB2 scavenger receptor class B, member 2 -0.844168
TNKS1BP1 tankyrase 1 binding protein 1, 182kDa -0.838231
ALDH4A1 aldehyde dehydrogenase 4 family, member A1 -0.835681
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -0.826421
PPIF peptidylprolyl isomerase F -0.825513