cytisine-6217 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the cytisine-6217 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKAP17A A kinase (PRKA) anchor protein 17A
AKR1C1 aldo-keto reductase family 1, member C1
ALOX5 arachidonate 5-lipoxygenase
ARID1A AT rich interactive domain 1A (SWI-like)
ARL4C ADP-ribosylation factor-like 4C
ASPHD1 aspartate beta-hydroxylase domain containing 1
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATN1 atrophin 1
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BMP5 bone morphogenetic protein 5
BRE brain and reproductive organ-expressed (TNFRSF1A modulator)
CA11 carbonic anhydrase XI
CCP110 centriolar coiled coil protein 110kDa
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CHST10 carbohydrate sulfotransferase 10
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLSPN claspin
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
ECE1 endothelin converting enzyme 1
ELOVL2 ELOVL fatty acid elongase 2
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
FBXL7 F-box and leucine-rich repeat protein 7
FN1 fibronectin 1
GJA4 gap junction protein, alpha 4, 37kDa
GLUD2 glutamate dehydrogenase 2
HDLBP high density lipoprotein binding protein
HIST1H2AJ histone cluster 1, H2aj
HOXD1 homeobox D1
ICAM1 intercellular adhesion molecule 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGHA1 immunoglobulin heavy constant alpha 1
INHBA inhibin, beta A
IRF6 interferon regulatory factor 6
JRK Jrk homolog (mouse)
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
LMAN1 lectin, mannose-binding, 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRRC41 leucine rich repeat containing 41
MCM3AP minichromosome maintenance complex component 3 associated protein
MFAP3L microfibrillar-associated protein 3-like
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NEBL nebulette
NEUROD4 neuronal differentiation 4
NFIB nuclear factor I/B
NR2F1 nuclear receptor subfamily 2, group F, member 1
OGFR opioid growth factor receptor
OSMR oncostatin M receptor
OVOL2 ovo-like zinc finger 2
PCDHB3 protocadherin beta 3
PDCD6 programmed cell death 6
PDGFA platelet-derived growth factor alpha polypeptide
PHC3 polyhomeotic homolog 3 (Drosophila)
PIN1P1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1
PLAU plasminogen activator, urokinase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PLSCR3 phospholipid scramblase 3
POFUT1 protein O-fucosyltransferase 1
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAB11B RAB11B, member RAS oncogene family
RAB2A RAB2A, member RAS oncogene family
RCAN3 RCAN family member 3
RNF219 ring finger protein 219
RNFT2 ring finger protein, transmembrane 2
SBF1 SET binding factor 1
SCN1B sodium channel, voltage gated, type I beta subunit
SFRP4 secreted frizzled-related protein 4
SGSM2 small G protein signaling modulator 2
SIRPA signal-regulatory protein alpha
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SRSF7 serine/arginine-rich splicing factor 7
SSPN sarcospan
ST7 suppression of tumorigenicity 7
SYNGR1 synaptogyrin 1
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TCP10L t-complex 10-like
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TFPI2 tissue factor pathway inhibitor 2
TLN2 talin 2
UBQLN4 ubiquilin 4
UBTD1 ubiquitin domain containing 1
UROD uroporphyrinogen decarboxylase
VARS valyl-tRNA synthetase
WIZ widely interspaced zinc finger motifs
ZMYND8 zinc finger, MYND-type containing 8
ZNF141 zinc finger protein 141
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
AKR1C3 aldo-keto reductase family 1, member C3
ANKRD36 ankyrin repeat domain 36
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARMC6 armadillo repeat containing 6
ATAD3A ATPase family, AAA domain containing 3A
ATP11B ATPase, class VI, type 11B
C19ORF40 chromosome 19 open reading frame 40
C21ORF91 chromosome 21 open reading frame 91
C5ORF45 chromosome 5 open reading frame 45
CAPG capping protein (actin filament), gelsolin-like
CCNL2 cyclin L2
CENPT centromere protein T
CLCN5 chloride channel, voltage-sensitive 5
COQ6 coenzyme Q6 monooxygenase
CORO2A coronin, actin binding protein, 2A
DDIT3 DNA-damage-inducible transcript 3
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DVL1 dishevelled segment polarity protein 1
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ERCC5 excision repair cross-complementation group 5
FAM118A family with sequence similarity 118, member A
FAM193B family with sequence similarity 193, member B
FKBP10 FK506 binding protein 10, 65 kDa
FMO4 flavin containing monooxygenase 4
FOXK2 forkhead box K2
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B
GFOD1 glucose-fructose oxidoreductase domain containing 1
GYS1 glycogen synthase 1 (muscle)
HOXC10 homeobox C10
IL17RA interleukin 17 receptor A
INF2 inverted formin, FH2 and WH2 domain containing
INO80D INO80 complex subunit D
JMJD4 jumonji domain containing 4
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
LRP5 low density lipoprotein receptor-related protein 5
MAMLD1 mastermind-like domain containing 1
MANBA mannosidase, beta A, lysosomal
MAPK12 mitogen-activated protein kinase 12
MFSD11 major facilitator superfamily domain containing 11
MOCS3 molybdenum cofactor synthesis 3
MORC3 MORC family CW-type zinc finger 3
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MRPL44 mitochondrial ribosomal protein L44
NR1H2 nuclear receptor subfamily 1, group H, member 2
ORAI3 ORAI calcium release-activated calcium modulator 3
PDZRN3 PDZ domain containing ring finger 3
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PLD3 phospholipase D family, member 3
PLEKHO1 pleckstrin homology domain containing, family O member 1
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PRR7 proline rich 7 (synaptic)
PTPRU protein tyrosine phosphatase, receptor type, U
QTRT1 queuine tRNA-ribosyltransferase 1
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAD54L2 RAD54-like 2 (S. cerevisiae)
RBL1 retinoblastoma-like 1
RBM42 RNA binding motif protein 42
RNF31 ring finger protein 31
RPS17P5 ribosomal protein S17 pseudogene 5
SCAI suppressor of cancer cell invasion
SETD1B SET domain containing 1B
SHARPIN SHANK-associated RH domain interactor
SMCO4 single-pass membrane protein with coiled-coil domains 4
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STX5 syntaxin 5
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
TBL3 transducin (beta)-like 3
TCTN1 tectonic family member 1
TEAD3 TEA domain family member 3
TMEM184B transmembrane protein 184B
TRAIP TRAF interacting protein
TRAPPC2 trafficking protein particle complex 2
TRIM25 tripartite motif containing 25
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TSPAN14 tetraspanin 14
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UBXN6 UBX domain protein 6
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
VAV1 vav 1 guanine nucleotide exchange factor
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae)
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
ZDHHC18 zinc finger, DHHC-type containing 18
ZNF211 zinc finger protein 211
ZNF23 zinc finger protein 23
ZNF492 zinc finger protein 492
ZNF552 zinc finger protein 552
ZNF573 zinc finger protein 573
ZNF675 zinc finger protein 675
ZNF767P zinc finger family member 767, pseudogene
ZNF816 zinc finger protein 816
ZXDC ZXD family zinc finger C