crohn's disease Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An intestinal disease that involves inflammation located_in intestine. (Human Disease Ontology, DOID_8778)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0100280
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Genes

252 genes associated with the crohn's disease phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
NOD2 nucleotide-binding oligomerization domain containing 2 3.38943
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 2.79315
IL23R interleukin 23 receptor 2.77877
CARD9 caspase recruitment domain family, member 9 2.34769
ZMIZ1 zinc finger, MIZ-type containing 1 2.23178
SNX20 sorting nexin 20 2.21018
SBNO2 strawberry notch homolog 2 (Drosophila) 2.03298
LACC1 laccase (multicopper oxidoreductase) domain containing 1 2.01845
C5ORF56 chromosome 5 open reading frame 56 1.99238
SMAD3 SMAD family member 3 1.9211
GPR65 G protein-coupled receptor 65 1.87101
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 1.84412
MST1 macrophage stimulating 1 1.83254
KSR1 kinase suppressor of ras 1 1.82094
SP140 SP140 nuclear body protein 1.81736
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 1.79316
NKX2-3 NK2 homeobox 3 1.77862
UBE2L3 ubiquitin-conjugating enzyme E2L 3 1.76413
PTPN2 protein tyrosine phosphatase, non-receptor type 2 1.75633
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 1.75033
FUT2 fucosyltransferase 2 (secretor status included) 1.75033
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.74205
ZGPAT zinc finger, CCCH-type with G patch domain 1.73304
AMT aminomethyltransferase 1.73021
THADA thyroid adenoma associated 1.67051
LOC285626 uncharacterized LOC285626 1.65004
SCAMP3 secretory carrier membrane protein 3 1.61591
FGFR1OP FGFR1 oncogene partner 1.5645
TYK2 tyrosine kinase 2 1.5645
BANK1 B-cell scaffold protein with ankyrin repeats 1 1.54733
IL18RAP interleukin 18 receptor accessory protein 1.54733
ATG16L2 autophagy related 16-like 2 (S. cerevisiae) 1.54307
BTNL2 butyrophilin-like 2 1.53903
BSN bassoon presynaptic cytomatrix protein 1.53584
ANKRD55 ankyrin repeat domain 55 1.53327
RNASET2 ribonuclease T2 1.51673
PUS10 pseudouridylate synthase 10 1.51005
TMEM258 transmembrane protein 258 1.48419
CLN3 ceroid-lipofuscinosis, neuronal 3 1.48419
GCKR glucokinase (hexokinase 4) regulator 1.45654
ERAP2 endoplasmic reticulum aminopeptidase 2 1.43716
PPP5C protein phosphatase 5, catalytic subunit 1.41863
RSPO3 R-spondin 3 1.38847
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 1.37122
KIF21B kinesin family member 21B 1.36284
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 1.35901
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 1.35901
ITLN1 intelectin 1 (galactofuranose binding) 1.35521
RTEL1 regulator of telomere elongation helicase 1 1.34581
IL2RA interleukin 2 receptor, alpha 1.30781
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 1.29495
PLCL1 phospholipase C-like 1 1.29386
JAZF1 JAZF zinc finger 1 1.29386
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 1.28282
CPEB4 cytoplasmic polyadenylation element binding protein 4 1.28282
PER3 period circadian clock 3 1.26545
ZNF365 zinc finger protein 365 1.26545
SLC22A23 solute carrier family 22, member 23 1.26545
ELF1 E74-like factor 1 (ets domain transcription factor) 1.25845
CCNY cyclin Y 1.25819
TEX9 testis expressed 9 1.25408
DENND1B DENN/MADD domain containing 1B 1.25251
MLN motilin 1.24751
APEH acylaminoacyl-peptide hydrolase 1.23766
NKD1 naked cuticle homolog 1 (Drosophila) 1.21922
SLAIN2 SLAIN motif family, member 2 1.21853
PTRF polymerase I and transcript release factor 1.19958
SKAP2 src kinase associated phosphoprotein 2 1.19958
CYLD cylindromatosis (turban tumor syndrome) 1.19722
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 1.19186
JAK2 Janus kinase 2 1.18371
TCTA T-cell leukemia translocation altered 1.14684
LINC00284 long intergenic non-protein coding RNA 284 1.14054
C1ORF141 chromosome 1 open reading frame 141 1.12851
C1ORF106 chromosome 1 open reading frame 106 1.12851
OSBPL3 oxysterol binding protein-like 3 1.12851
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 1.12583
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 1.11716
NOTCH1 notch 1 1.11577
LYRM4 LYR motif containing 4 1.10546
RHOA ras homolog family member A 1.1036
FCHSD2 FCH and double SH3 domains 2 1.09906
NICN1 nicolin 1 1.09698
BCAS3 breast carcinoma amplified sequence 3 1.08625
CD244 CD244 molecule, natural killer cell receptor 2B4 1.07729
PSORS1C3 psoriasis susceptibility 1 candidate 3 (non-protein coding) 1.0674
GRK5 G protein-coupled receptor kinase 5 1.04668
C6ORF10 chromosome 6 open reading frame 10 1.02775
USP4 ubiquitin specific peptidase 4 (proto-oncogene) 1.02683
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6 1.02205
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1 1.00488
LOC285484 uncharacterized LOC285484 0.974566
NELL1 NEL-like 1 (chicken) 0.969142
ITGA9 integrin, alpha 9 0.968323
BSN-AS2 BSN antisense RNA 2 (head to head) 0.964112
HLA-DOB major histocompatibility complex, class II, DO beta 0.963857
WDR78 WD repeat domain 78 0.953171
CDC42SE2 CDC42 small effector 2 0.952379
WDR27 WD repeat domain 27 0.947546
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.945358
LDLRAD3 low density lipoprotein receptor class A domain containing 3 0.939894
IL3 interleukin 3 0.939636
MYH16 myosin, heavy chain 16 pseudogene 0.932945
CARD8 caspase recruitment domain family, member 8 0.921387
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 0.903602
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.899912
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 0.899912
TMEM47 transmembrane protein 47 0.899372
MIER1 mesoderm induction early response 1, transcriptional regulator 0.897595
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.897244
IQCB1 IQ motif containing B1 0.894486
ACSL6 acyl-CoA synthetase long-chain family member 6 0.892806
ZDHHC23 zinc finger, DHHC-type containing 23 0.882984
ZBTB16 zinc finger and BTB domain containing 16 0.870998
F11 coagulation factor XI 0.870858
CAPZB capping protein (actin filament) muscle Z-line, beta 0.868241
CCDC169 coiled-coil domain containing 169 0.865569
GPSM3 G-protein signaling modulator 3 0.862298
LOC728637 0.861012
RUNX3 runt-related transcription factor 3 0.855449
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.85426
FAM92B family with sequence similarity 92, member B 0.849104
ANKRD44 ankyrin repeat domain 44 0.846368
ZNF664-FAM101A filamin-interacting protein FAM101A 0.845298
TRAIP TRAF interacting protein 0.835282
CCDC38 coiled-coil domain containing 38 0.82634
CAMKV CaM kinase-like vesicle-associated 0.81601
RALGDS ral guanine nucleotide dissociation stimulator 0.807817
IP6K1 inositol hexakisphosphate kinase 1 0.801631
AKAP13 A kinase (PRKA) anchor protein 13 0.790435
NCF4 neutrophil cytosolic factor 4, 40kDa 0.787244
SUGT1P3 SUGT1 pseudogene 3 0.787244
PRIM2 primase, DNA, polypeptide 2 (58kDa) 0.784165
FNIP1 folliculin interacting protein 1 0.782964
ZFPM2 zinc finger protein, FOG family member 2 0.778318
TTC6 tetratricopeptide repeat domain 6 0.778318
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.776638
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.774448
BATF basic leucine zipper transcription factor, ATF-like 0.759822
IL1R2 interleukin 1 receptor, type II 0.759303
BRD2 bromodomain containing 2 0.756252
MUC21 mucin 21, cell surface associated 0.74997
MST1R macrophage stimulating 1 receptor 0.744535
PRPF18 pre-mRNA processing factor 18 0.738997
RADIL Ras association and DIL domains 0.734535
FREM2 FRAS1 related extracellular matrix protein 2 0.726078
MON1A MON1 secretory trafficking family member A 0.718314
ZNF532 zinc finger protein 532 0.71647
COL11A2 collagen, type XI, alpha 2 0.708638
FDPS farnesyl diphosphate synthase 0.697013
ROR1 receptor tyrosine kinase-like orphan receptor 1 0.686623
RHOU ras homolog family member U 0.684556
NOTCH4 notch 4 0.682819
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.681679
DZIP1 DAZ interacting zinc finger protein 1 0.679668
EPHB2 EPH receptor B2 0.678743
COL23A1 collagen, type XXIII, alpha 1 0.661809
TET2 tet methylcytosine dioxygenase 2 0.661032
CHSY3 chondroitin sulfate synthase 3 0.660006
KAZN kazrin, periplakin interacting protein 0.657487
SPON1 spondin 1, extracellular matrix protein 0.655272
SORCS2 sortilin-related VPS10 domain containing receptor 2 0.655029
TNXB tenascin XB 0.651454
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 0.650754
GSDMB gasdermin B 0.650754
ATRNL1 attractin-like 1 0.64787
CCDC91 coiled-coil domain containing 91 0.646616
SCN3A sodium channel, voltage gated, type III alpha subunit 0.644641
HLA-DPB2 major histocompatibility complex, class II, DP beta 2 (pseudogene) 0.638927
CLSTN2 calsyntenin 2 0.637546
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 0.632852
VAMP3 vesicle-associated membrane protein 3 0.620318
MACROD2 MACRO domain containing 2 0.614589
RNF5 ring finger protein 5, E3 ubiquitin protein ligase 0.590091
FBXL13 F-box and leucine-rich repeat protein 13 0.589794
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 0.589645
HPSE2 heparanase 2 (inactive) 0.587883
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.583787
SORCS1 sortilin-related VPS10 domain containing receptor 1 0.579744
BCL9 B-cell CLL/lymphoma 9 0.574666
POU5F1 POU class 5 homeobox 1 0.573902
LDLRAD4 low density lipoprotein receptor class A domain containing 4 0.572823
MAML2 mastermind-like 2 (Drosophila) 0.55536
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 0.549174
TCF19 transcription factor 19 0.545167
AGER advanced glycosylation end product-specific receptor 0.541144
TAGAP T-cell activation RhoGTPase activating protein 0.537883
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.531556
GPC6 glypican 6 0.528162
KAT6B K(lysine) acetyltransferase 6B 0.525058
MB21D2 Mab-21 domain containing 2 0.525058
SLC9A4 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 0.521292
CCHCR1 coiled-coil alpha-helical rod protein 1 0.520736
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.520461
ARHGAP19 Rho GTPase activating protein 19 0.509391
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.509391
CLUL1 clusterin-like 1 (retinal) 0.509391
VSTM4 V-set and transmembrane domain containing 4 0.502867
CHD9 chromodomain helicase DNA binding protein 9 0.502058
RAB6B RAB6B, member RAS oncogene family 0.50086
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.498792
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.496801
TEX41 testis expressed 41 (non-protein coding) 0.496801
CSMD1 CUB and Sushi multiple domains 1 0.496801
ZNF311 zinc finger protein 311 0.496801
CD36 CD36 molecule (thrombospondin receptor) 0.49303
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 0.490542
SULF2 sulfatase 2 0.490369
MTMR3 myotubularin related protein 3 0.488001
QPCT glutaminyl-peptide cyclotransferase 0.486163
CFB complement factor B 0.483087
NPAS3 neuronal PAS domain protein 3 0.478004
GDPD4 glycerophosphodiester phosphodiesterase domain containing 4 0.472241
CCDC85A coiled-coil domain containing 85A 0.470822
HLA-DRA major histocompatibility complex, class II, DR alpha 0.469516
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.469373
FHIT fragile histidine triad 0.469373
MARCH11 membrane-associated ring finger (C3HC4) 11 0.468803
SRPK1 SRSF protein kinase 1 0.467264
COL19A1 collagen, type XIX, alpha 1 0.465228
SLC14A2 solute carrier family 14 (urea transporter), member 2 0.462619
TUBD1 tubulin, delta 1 0.459271
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 0.45496
MIPEP mitochondrial intermediate peptidase 0.453147
FERMT1 fermitin family member 1 0.452152
PDE8A phosphodiesterase 8A 0.452042
TEK TEK tyrosine kinase, endothelial 0.449892
HLA-C major histocompatibility complex, class I, C 0.446609
LPPR5 lipid phosphate phosphatase-related protein type 5 0.443881
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.442937
NOS2 nitric oxide synthase 2, inducible 0.440732
DNAH11 dynein, axonemal, heavy chain 11 0.440194
NPSR1 neuropeptide S receptor 1 0.440194
COL25A1 collagen, type XXV, alpha 1 0.439501
CNTNAP5 contactin associated protein-like 5 0.438967
GRM5 glutamate receptor, metabotropic 5 0.438588
SCUBE3 signal peptide, CUB domain, EGF-like 3 0.438213
ITGB6 integrin, beta 6 0.43784
AGBL4 ATP/GTP binding protein-like 4 0.434255
FAM188A family with sequence similarity 188, member A 0.434255
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 0.433568
RAB12 RAB12, member RAS oncogene family 0.43289
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 0.432221
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 0.430459
MYO5B myosin VB 0.429005
WDR46 WD repeat domain 46 0.428881
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.428386
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.427171
SIDT1 SID1 transmembrane family, member 1 0.427171
DSCAM Down syndrome cell adhesion molecule 0.426061
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.425664
SGCZ sarcoglycan, zeta 0.425664