cowden disease Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description An autosomal dominant disease characterized by multiple noncancerous, tumor-like growths (hamartomas) and an increased risk of certain forms of cancer, especially breast, thyroid and endometrium. It is caused by mutations in the PTEN, SDHB, SDHD and KLLN genes. (Human Disease Ontology, DOID_6457)
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61 genes co-occuring with the disease cowden disease in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
PTEN phosphatase and tensin homolog 3.00358
KLLN killin, p53-regulated DNA replication inhibitor 1.7948
TNS1 tensin 1 1.76275
LYPD1 LY6/PLAUR domain containing 1 1.69633
BMPR1A bone morphogenetic protein receptor, type IA 1.53348
BRCA1 breast cancer 1, early onset 1.17206
BRCA2 breast cancer 2, early onset 1.16692
STK11 serine/threonine kinase 11 1.10973
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.06564
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 1.03282
STK11IP serine/threonine kinase 11 interacting protein 0.999924
MINPP1 multiple inositol-polyphosphate phosphatase 1 0.995283
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein 0.904442
SMAD4 SMAD family member 4 0.816745
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 0.793771
GDF10 growth differentiation factor 10 0.772479
RASAL1 RAS protein activator like 1 (GAP1 like) 0.760639
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.733406
TP53 tumor protein p53 0.711587
RET ret proto-oncogene 0.686691
GGTLC2 gamma-glutamyltransferase light chain 2 0.685891
TSC2 tuberous sclerosis 2 0.668345
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.663181
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa 0.658026
CHEK2 checkpoint kinase 2 0.626888
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 0.614747
STRADA STE20-related kinase adaptor alpha 0.609666
TCF4 transcription factor 4 0.559062
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.526518
PTPRD protein tyrosine phosphatase, receptor type, D 0.519961
CHRD chordin 0.491597
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.490454
NF1 neurofibromin 1 0.480186
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 0.463905
SPRED1 sprouty-related, EVH1 domain containing 1 0.43227
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.430768
RELN reelin 0.42364
MUTYH mutY homolog 0.419892
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.389653
MIR19A microRNA 19a 0.385193
MEN1 multiple endocrine neoplasia I 0.377402
L1CAM L1 cell adhesion molecule 0.372958
LPIN1 lipin 1 0.340173
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.335412
GJA5 gap junction protein, alpha 5, 40kDa 0.32774
DCX doublecortin 0.30342
THEM4 thioesterase superfamily member 4 0.290821
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.280439
CXCL14 chemokine (C-X-C motif) ligand 14 0.274021
RHEB Ras homolog enriched in brain 0.246448
USF2 upstream transcription factor 2, c-fos interacting 0.245046
FLNA filamin A, alpha 0.243645
PGLS 6-phosphogluconolactonase 0.231795
CALCA calcitonin-related polypeptide alpha 0.226607
CAV2 caveolin 2 0.210253
EFNB2 ephrin-B2 0.194232
CLEC2A C-type lectin domain family 2, member A 0.187415
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) 0.185612
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 0.165874
PALB2 partner and localizer of BRCA2 0.160761
CYLD cylindromatosis (turban tumor syndrome) 0.160021