costamere Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix. (Gene Ontology, GO_0043034)
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Genes

80 proteins co-occuring with the costamere cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
VCL vinculin 1.95442
DMD dystrophin 1.68055
CMYA5 cardiomyopathy associated 5 1.46722
TLN2 talin 2 1.30336
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 1.26022
SYNM synemin, intermediate filament protein 1.10256
SPTB spectrin, beta, erythrocytic 1.03378
DCTN4 dynactin 4 (p62) 1.02082
NEB nebulin 0.970331
POMK protein-O-mannose kinase 0.966956
LIMS2 LIM and senescent cell antigen-like domains 2 0.945907
TLN1 talin 1 0.945432
LIMS3 LIM and senescent cell antigen-like domains 3 0.935488
RAVER1 ribonucleoprotein, PTB-binding 1 0.935488
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 0.898572
TTN titin 0.896257
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.849746
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 0.779126
CRIP3 cysteine-rich protein 3 0.770451
MEF2A myocyte enhancer factor 2A 0.768627
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 0.745929
SVIL supervillin 0.736014
SORBS1 sorbin and SH3 domain containing 1 0.727941
FLNC filamin C, gamma 0.717236
PTK2 protein tyrosine kinase 2 0.679849
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.661208
PXN paxillin 0.641429
ANK1 ankyrin 1, erythrocytic 0.638861
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 0.603596
DYSF dysferlin 0.576329
SNTG1 syntrophin, gamma 1 0.575912
ACTG1 actin gamma 1 0.560114
ANK2 ankyrin 2, neuronal 0.53906
UQCRC1 ubiquinol-cytochrome c reductase core protein I 0.496205
NOS1 nitric oxide synthase 1 (neuronal) 0.491348
PDLIM3 PDZ and LIM domain 3 0.490539
BHLHE22 basic helix-loop-helix family, member e22 0.475625
LAMA3 laminin, alpha 3 0.473215
AKAP1 A kinase (PRKA) anchor protein 1 0.462798
UTRN utrophin 0.448054
UNC45B unc-45 homolog B (C. elegans) 0.427104
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 0.427104
CAV3 caveolin 3 0.419644
PARVB parvin, beta 0.41612
TRIM32 tripartite motif containing 32 0.412992
DNM2 dynamin 2 0.409089
ILK integrin-linked kinase 0.407529
COL13A1 collagen, type XIII, alpha 1 0.402081
DES desmin 0.398587
MYOZ1 myozenin 1 0.394323
FXR2 fragile X mental retardation, autosomal homolog 2 0.383895
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 0.380814
FKRP fukutin related protein 0.374666
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa 0.367388
LAMA2 laminin, alpha 2 0.363567
SDC4 syndecan 4 0.362804
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 0.359752
PTBP1 polypyrimidine tract binding protein 1 0.352522
SNTA1 syntrophin, alpha 1 0.344178
NCK2 NCK adaptor protein 2 0.341529
NCK1 NCK adaptor protein 1 0.338884
PLEC plectin 0.333979
FERMT2 fermitin family member 2 0.32195
AKAP12 A kinase (PRKA) anchor protein 12 0.320451
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 0.312971
PARVA parvin, alpha 0.306632
HMOX2 heme oxygenase 2 0.30626
ARHGAP21 Rho GTPase activating protein 21 0.303655
ZYX zyxin 0.30254
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.295489
FN1 fibronectin 1 0.230601
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2 0.229176
GFAP glial fibrillary acidic protein 0.211587
ACTB actin, beta 0.200663
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.188274
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.187646
RAPSN receptor-associated protein of the synapse 0.1632
CENPF centromere protein F, 350/400kDa 0.162117
MYEF2 myelin expression factor 2 0.160053
ACTN2 actinin, alpha 2 0.158882