contractile fiber Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle. (Gene Ontology, GO_0043292)
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Genes

378 proteins co-occuring with the contractile fiber cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
TTN titin 3.40863
TNNT2 troponin T type 2 (cardiac) 3.23097
TNNI3 troponin I type 3 (cardiac) 2.89531
TPM1 tropomyosin 1 (alpha) 2.62868
NEB nebulin 2.39598
MYBPC3 myosin binding protein C, cardiac 2.17272
MYOM2 myomesin 2 2.03796
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 1.79707
MYOT myotilin 1.7695
DNAH8 dynein, axonemal, heavy chain 8 1.75724
MYBPC2 myosin binding protein C, fast type 1.71808
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 1.70322
MB myoglobin 1.69277
MYH7 myosin, heavy chain 7, cardiac muscle, beta 1.6106
LDB3 LIM domain binding 3 1.6001
FLNC filamin C, gamma 1.58449
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 1.57302
DMD dystrophin 1.55424
VCL vinculin 1.53161
MYL2 myosin, light chain 2, regulatory, cardiac, slow 1.52259
CAPN3 calpain 3, (p94) 1.4429
MYOZ1 myozenin 1 1.32654
CRYAB crystallin, alpha B 1.30604
CAST calpastatin 1.29317
MYPN myopalladin 1.28676
NEBL nebulette 1.28356
ACTN2 actinin, alpha 2 1.27292
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 1.2708
MYOZ2 myozenin 2 1.26075
TCAP titin-cap 1.24131
TNNI1 troponin I type 1 (skeletal, slow) 1.234
FABP3 fatty acid binding protein 3, muscle and heart 1.21221
MYOM1 myomesin 1 1.20963
CKM creatine kinase, muscle 1.19211
TPM2 tropomyosin 2 (beta) 1.15057
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 1.14597
NPPB natriuretic peptide B 1.14034
NPPA natriuretic peptide A 1.1199
CAPN2 calpain 2, (m/II) large subunit 1.11429
MYBPC1 myosin binding protein C, slow type 1.10664
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 1.10511
MYOD1 myogenic differentiation 1 1.08933
SYNM synemin, intermediate filament protein 1.07968
PYGB phosphorylase, glycogen; brain 1.07714
PYGL phosphorylase, glycogen, liver 1.07613
PYGM phosphorylase, glycogen, muscle 1.07359
TPM3 tropomyosin 3 1.07258
PDLIM3 PDZ and LIM domain 3 1.06498
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase 1.04381
ACTC1 actin, alpha, cardiac muscle 1 1.04331
BAG3 BCL2-associated athanogene 3 1.03529
CASQ2 calsequestrin 2 (cardiac muscle) 1.03378
UNC45B unc-45 homolog B (C. elegans) 1.03228
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 1.02929
PLN phospholamban 1.02829
MGAM maltase-glucoamylase 1.0248
CALM1 calmodulin 1 (phosphorylase kinase, delta) 1.0104
MYLK myosin light chain kinase 1.00794
CALM3 calmodulin 3 (phosphorylase kinase, delta) 1.00547
CALM2 calmodulin 2 (phosphorylase kinase, delta) 1.00497
GATA4 GATA binding protein 4 1.003
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 0.982446
HSPB2 heat shock 27kDa protein 2 0.982446
MYOG myogenin (myogenic factor 4) 0.973714
DES desmin 0.957352
GSN gelsolin 0.950189
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.933601
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.921386
RYR1 ryanodine receptor 1 (skeletal) 0.905067
CMYA5 cardiomyopathy associated 5 0.899962
FBXO32 F-box protein 32 0.899036
FHL2 four and a half LIM domains 2 0.895331
FN1 fibronectin 1 0.895331
PFKM phosphofructokinase, muscle 0.893943
NRAP nebulin-related anchoring protein 0.872726
DYSF dysferlin 0.859852
CTNS cystinosin, lysosomal cystine transporter 0.856635
ANK1 ankyrin 1, erythrocytic 0.844696
TNNI2 troponin I type 2 (skeletal, fast) 0.838269
TMOD1 tropomodulin 1 0.831843
TNNT3 troponin T type 3 (skeletal, fast) 0.830007
GJA1 gap junction protein, alpha 1, 43kDa 0.827712
PKLR pyruvate kinase, liver and RBC 0.800187
TRIM32 tripartite motif containing 32 0.794687
TMOD4 tropomodulin 4 (muscle) 0.794687
C16ORF82 chromosome 16 open reading frame 82 0.781412
MSTN myostatin 0.781412
CAV3 caveolin 3 0.776384
ACTA1 actin, alpha 1, skeletal muscle 0.773188
PKM pyruvate kinase, muscle 0.764072
CRP C-reactive protein, pentraxin-related 0.760433
MEF2C myocyte enhancer factor 2C 0.751357
MYL1 myosin, light chain 1, alkali; skeletal, fast 0.750452
CFL2 cofilin 2 (muscle) 0.749094
SMYD1 SET and MYND domain containing 1 0.740515
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.738263
DNM2 dynamin 2 0.733768
PNMA2 paraneoplastic Ma antigen 2 0.726152
ACTG1 actin gamma 1 0.719906
TRIM55 tripartite motif containing 55 0.713682
PVALB parvalbumin 0.706156
PALLD palladin, cytoskeletal associated protein 0.677673
GFAP glial fibrillary acidic protein 0.677238
CTSS cathepsin S 0.672894
TBX5 T-box 5 0.67246
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 0.657326
TLN2 talin 2 0.654311
CS citrate synthase 0.647862
CKB creatine kinase, brain 0.638861
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.625206
FHL1 four and a half LIM domains 1 0.625206
MYBPH myosin binding protein H 0.62393
S100A1 S100 calcium binding protein A1 0.621804
FKTN fukutin 0.620104
OBSL1 obscurin-like 1 0.615437
CSN1S1 casein alpha s1 0.614589
ACHE acetylcholinesterase (Yt blood group) 0.614165
ALB albumin 0.612471
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.604862
MYOZ3 myozenin 3 0.603596
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 0.601909
ENO3 enolase 3 (beta, muscle) 0.592652
RBM20 RNA binding motif protein 20 0.592232
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.591812
MYF6 myogenic factor 6 (herculin) 0.590553
EDN1 endothelin 1 0.590553
INS insulin 0.588456
TNNT1 troponin T type 1 (skeletal, slow) 0.588456
CKMT1B creatine kinase, mitochondrial 1B 0.58678
SEPN1 selenoprotein N, 1 0.584686
RBM24 RNA binding motif protein 24 0.581758
TPM4 tropomyosin 4 0.578833
MYOM3 myomesin 3 0.578833
MEF2A myocyte enhancer factor 2A 0.575495
TRIM54 tripartite motif containing 54 0.569664
QDPR quinoid dihydropteridine reductase 0.564262
PIGM phosphatidylinositol glycan anchor biosynthesis, class M 0.563847
RYR2 ryanodine receptor 2 (cardiac) 0.562602
MURC muscle-related coiled-coil protein 0.550186
MYF5 myogenic factor 5 0.546885
CAPZB capping protein (actin filament) muscle Z-line, beta 0.545236
SPTB spectrin, beta, erythrocytic 0.544411
TRDN triadin 0.53906
TMBIM4 transmembrane BAX inhibitor motif containing 4 0.537416
DMPK dystrophia myotonica-protein kinase 0.535772
CKMT1A creatine kinase, mitochondrial 1A 0.53413
MYH1 myosin, heavy chain 1, skeletal muscle, adult 0.528798
IGF1 insulin-like growth factor 1 (somatomedin C) 0.525931
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic 0.524704
CALD1 caldesmon 1 0.523476
ALPK3 alpha-kinase 3 0.518573
PDE5A phosphodiesterase 5A, cGMP-specific 0.513677
FHOD3 formin homology 2 domain containing 3 0.51327
SYNPO2 synaptopodin 2 0.510826
ACE angiotensin I converting enzyme 0.504318
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.498636
FKRP fukutin related protein 0.498636
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.49499
PGAM2 phosphoglycerate mutase 2 (muscle) 0.492966
CCDC140 coiled-coil domain containing 140 0.487711
XIRP1 xin actin binding repeat containing 1 0.483676
MMP10 matrix metallopeptidase 10 0.478843
PARVB parvin, beta 0.476831
LCN2 lipocalin 2 0.476429
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.472813
LIMS2 LIM and senescent cell antigen-like domains 2 0.470807
ANKRD23 ankyrin repeat domain 23 0.470005
SOD2 superoxide dismutase 2, mitochondrial 0.468802
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 0.464798
LIMS3 LIM and senescent cell antigen-like domains 3 0.461998
NCKIPSD NCK interacting protein with SH3 domain 0.460001
JPH2 junctophilin 2 0.459203
BPGM 2,3-bisphosphoglycerate mutase 0.457606
PGAM1 phosphoglycerate mutase 1 (brain) 0.456012
CAPZA3 capping protein (actin filament) muscle Z-line, alpha 3 0.453223
YIPF1 Yip1 domain family, member 1 0.451631
ILK integrin-linked kinase 0.446862
STAC3 SH3 and cysteine rich domain 3 0.440916
PXN paxillin 0.434196
TCEA3 transcription elongation factor A (SII), 3 0.432224
SIMC1 SUMO-interacting motifs containing 1 0.432224
BAG1 BCL2-associated athanogene 0.432224
C15ORF52 chromosome 15 open reading frame 52 0.432224
MYOCD myocardin 0.431435
MIR22 microRNA 22 0.429859
XIRP2 xin actin binding repeat containing 2 0.429072
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.428284
MYEF2 myelin expression factor 2 0.425924
NEXN nexilin (F actin binding protein) 0.424353
CTAG2 cancer/testis antigen 2 0.421604
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 0.421604
AK1 adenylate kinase 1 0.414164
BCHE butyrylcholinesterase 0.414164
MEF2D myocyte enhancer factor 2D 0.413773
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.408309
IKZF3 IKAROS family zinc finger 3 (Aiolos) 0.404026
HSPB3 heat shock 27kDa protein 3 0.403248
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.40247
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 0.401693
MYO1A myosin IA 0.400139
GDF15 growth differentiation factor 15 0.399751
FBXL22 F-box and leucine-rich repeat protein 22 0.399363
HAND2 heart and neural crest derivatives expressed 2 0.398975
LMNA lamin A/C 0.393936
LRTM1 leucine-rich repeats and transmembrane domains 1 0.392775
ANK2 ankyrin 2, neuronal 0.383509
MYO5A myosin VA (heavy chain 12, myoxin) 0.383509
SMYD5 SMYD family member 5 0.381199
BAG2 BCL2-associated athanogene 2 0.380045
CALR3 calreticulin 3 0.380045
SMYD4 SET and MYND domain containing 4 0.375434
TLN1 talin 1 0.37505
ATP11A ATPase, class VI, type 11A 0.373899
CA3 carbonic anhydrase III 0.373132
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 0.371982
PDLIM5 PDZ and LIM domain 5 0.365859
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 0.365477
MYL5 myosin, light chain 5, regulatory 0.364331
CAT catalase 0.363949
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle 0.36204
FTL ferritin, light polypeptide 0.361277
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.360515
FTH1 ferritin, heavy polypeptide 1 0.359752
FLNA filamin A, alpha 0.356705
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 0.354422
PAX7 paired box 7 0.351382
LRRC39 leucine rich repeat containing 39 0.350243
SRI sorcin 0.349105
TCF15 transcription factor 15 (basic helix-loop-helix) 0.349105
TAZ tafazzin 0.347967
SMYD2 SET and MYND domain containing 2 0.343042
ZYX zyxin 0.341907
MTM1 myotubularin 1 0.341529
FEN1 flap structure-specific endonuclease 1 0.341151
ACPP acid phosphatase, prostate 0.340395
BIN1 bridging integrator 1 0.339261
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.334733
RIPK4 receptor-interacting serine-threonine kinase 4 0.333225
GPX5 glutathione peroxidase 5 0.332095
RCAN1 regulator of calcineurin 1 0.331342
DCTN4 dynactin 4 (p62) 0.330213
NBR1 neighbor of BRCA1 gene 1 0.329837
ACTB actin, beta 0.327581
GPX4 glutathione peroxidase 4 0.326829
DUSP27 dual specificity phosphatase 27 (putative) 0.324951
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.32195
REN renin 0.318579
CTSB cathepsin B 0.317082
CST3 cystatin C 0.316708
GPX1 glutathione peroxidase 1 0.316334
MMP2 matrix metallopeptidase 2 0.315586
KCTD6 potassium channel tetramerization domain containing 6 0.313344
GPBP1 GC-rich promoter binding protein 1 0.312597
MYH2 myosin, heavy chain 2, skeletal muscle, adult 0.311478
LMOD3 leiomodin 3 (fetal) 0.310732
LGALS3 lectin, galactoside-binding, soluble, 3 0.301054
DUPD1 dual specificity phosphatase and pro isomerase domain containing 1 0.299569
AMPD1 adenosine monophosphate deaminase 1 0.29623
APOLD1 apolipoprotein L domain containing 1 0.294378
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.292527
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.290308
ADM adrenomedullin 0.289938
SFI1 Sfi1 homolog, spindle assembly associated (yeast) 0.289938
POMK protein-O-mannose kinase 0.289199
NOS1 nitric oxide synthase 1 (neuronal) 0.288829
ATE1 arginyltransferase 1 0.282926
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 0.278509
HK1 hexokinase 1 0.275569
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.275202
LRRC10 leucine rich repeat containing 10 0.273734
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.2708
SORBS1 sorbin and SH3 domain containing 1 0.269701
TNNC1 troponin C type 1 (slow) 0.268969
FMN1 formin 1 0.267139
RAVER1 ribonucleoprotein, PTB-binding 1 0.264946
BMP10 bone morphogenetic protein 10 0.264581
FRG1 FSHD region gene 1 0.26312
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 0.254743
LAMP2 lysosomal-associated membrane protein 2 0.254017
PRKD1 protein kinase D1 0.254017
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.253291
PFDN4 prefoldin subunit 4 0.252202
SORBS2 sorbin and SH3 domain containing 2 0.251114
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 0.247854
DSP desmoplakin 0.246769
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 0.246046
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.243519
INMT indolethylamine N-methyltransferase 0.243158
TYRO3 TYRO3 protein tyrosine kinase 0.241356
UTRN utrophin 0.238837
FBP1 fructose-1,6-bisphosphatase 1 0.238478
ZFPM1 zinc finger protein, FOG family member 1 0.235966
ALPP alkaline phosphatase, placental 0.235249
ALPPL2 alkaline phosphatase, placental-like 2 0.234533
ALPL alkaline phosphatase, liver/bone/kidney 0.234174
JMJD6 jumonji domain containing 6 0.229888
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.228819
AHNAK2 AHNAK nucleoprotein 2 0.228464
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 0.227752
CTSD cathepsin D 0.227041
TUBE1 tubulin, epsilon 1 0.225622
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.224913
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.224204
FERMT2 fermitin family member 2 0.222436
DST dystonin 0.220321
ROCK1P1 Rho-associated, coiled-coil containing protein kinase 1 pseudogene 1 0.218563
NEURL1 neuralized E3 ubiquitin protein ligase 1 0.217511
TXLNB taxilin beta 0.215063
ACTA2 actin, alpha 2, smooth muscle, aorta 0.214366
CAND2 cullin-associated and neddylation-dissociated 2 (putative) 0.214017
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa 0.213322
FILIP1L filamin A interacting protein 1-like 0.212974
MYO1B myosin IB 0.21228
HAND1 heart and neural crest derivatives expressed 1 0.210549
CTSL cathepsin L 0.209169
NOS3 nitric oxide synthase 3 (endothelial cell) 0.209169
MYH9 myosin, heavy chain 9, non-muscle 0.204718
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 0.203361
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.202009
GATA6 GATA binding protein 6 0.201672
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 0.199993
PARVA parvin, alpha 0.199325
C1QTNF3 C1q and tumor necrosis factor related protein 3 0.197662
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal 0.19733
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) 0.194045
HRAS Harvey rat sarcoma viral oncogene homolog 0.193719
GLB1 galactosidase, beta 1 0.19307
MYLK2 myosin light chain kinase 2 0.191777
CAPNS1 calpain, small subunit 1 0.190495
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.18859
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.187646
CAMK2B calcium/calmodulin-dependent protein kinase II beta 0.186087
LAMA2 laminin, alpha 2 0.185469
BCO2 beta-carotene oxygenase 2 0.18516
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 0.184241
EMD emerin 0.183328
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase 0.183025
FAM189B family with sequence similarity 189, member B 0.181524
ALDOC aldolase C, fructose-bisphosphate 0.18093
RCAN3 RCAN family member 3 0.180634
AKAP1 A kinase (PRKA) anchor protein 1 0.180339
AHNAK AHNAK nucleoprotein 0.180339
NEURL2 neuralized E3 ubiquitin protein ligase 2 0.179459
HES3 hes family bHLH transcription factor 3 0.178011
LMCD1 LIM and cysteine-rich domains 1 0.17687
FOXO3 forkhead box O3 0.175466
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 0.175188
POTEI POTE ankyrin domain family, member I 0.174087
ACT actin-like protein (ACT) gene 0.171673
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 0.170629
POTEF POTE ankyrin domain family, member F 0.169859
AR androgen receptor 0.167856
CAPN1 calpain 1, (mu/I) large subunit 0.166884
NES nestin 0.166167
PTK2 protein tyrosine kinase 2 0.165932
GMEB1 glucocorticoid modulatory element binding protein 1 0.165231
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 0.16298
ENHO energy homeostasis associated 0.162117
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 0.160053
CD40LG CD40 ligand 0.159658
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) 0.159462
GAA glucosidase, alpha; acid 0.158882
VPREB1 pre-B lymphocyte 1 0.156863
ERG v-ets avian erythroblastosis virus E26 oncogene homolog 0.141632
TAC1 tachykinin, precursor 1 0.140851
PTK7 protein tyrosine kinase 7 (inactive) 0.140846
NPY neuropeptide Y 0.140651
BCAN brevican 0.14018
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 0.138973
GAL galanin/GMAP prepropeptide 0.138589
VIP vasoactive intestinal peptide 0.137323
TRIM37 tripartite motif containing 37 0.136907
PIWIL1 piwi-like RNA-mediated gene silencing 1 0.136087
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.132978
CALCA calcitonin-related polypeptide alpha 0.130484
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 0.129929
YIPF2 Yip1 domain family, member 2 0.128213
CRIP3 cysteine-rich protein 3 0.128146