contractile fiber Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle. (Gene Ontology, GO_0043292)
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Genes

194 proteins localized to the contractile fiber cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
ANK1 ankyrin 1, erythrocytic 0.663342
RYR1 ryanodine receptor 1 (skeletal) 0.663342
FRG1 FSHD region gene 1 0.663342
DMD dystrophin 0.663342
NEBL nebulette 0.663342
SYNM synemin, intermediate filament protein 0.663342
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase 0.663342
SYNE2 spectrin repeat containing, nuclear envelope 2 0.663342
SYNE1 spectrin repeat containing, nuclear envelope 1 0.663342
ACTA1 actin, alpha 1, skeletal muscle 0.663342
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 0.663342
ACTC1 actin, alpha, cardiac muscle 1 0.663342
ILK integrin-linked kinase 0.663342
FBP2 fructose-1,6-bisphosphatase 2 0.663342
KRT19 keratin 19, type I 0.663342
SCO2 SCO2 cytochrome c oxidase assembly protein 0.663342
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 0.663342
NEB nebulin 0.663342
MYOZ2 myozenin 2 0.663342
FLNB filamin B, beta 0.663342
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.663342
PGM5 phosphoglucomutase 5 0.663342
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.663342
TPM3 tropomyosin 3 0.663342
SVIL supervillin 0.663342
TNNT3 troponin T type 3 (skeletal, fast) 0.663342
TNNT2 troponin T type 2 (cardiac) 0.663342
TNNI2 troponin I type 2 (skeletal, fast) 0.663342
TNNI3 troponin I type 3 (cardiac) 0.663342
MYH13 myosin, heavy chain 13, skeletal muscle 0.663342
DST dystonin 0.663342
LDB3 LIM domain binding 3 0.663342
MYH2 myosin, heavy chain 2, skeletal muscle, adult 0.663342
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic 0.663342
MYH4 myosin, heavy chain 4, skeletal muscle 0.663342
ALDOA aldolase A, fructose-bisphosphate 0.663342
ACTN2 actinin, alpha 2 0.663342
MYH1 myosin, heavy chain 1, skeletal muscle, adult 0.663342
TNNT1 troponin T type 1 (skeletal, slow) 0.663342
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 0.663342
PARVB parvin, beta 0.663342
FHOD3 formin homology 2 domain containing 3 0.663342
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal 0.663342
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 0.663342
DES desmin 0.663342
SORBS2 sorbin and SH3 domain containing 2 0.663342
MYH15 myosin, heavy chain 15 0.663342
MYOT myotilin 0.663342
SCO1 SCO1 cytochrome c oxidase assembly protein 0.663342
PALLD palladin, cytoskeletal associated protein 0.663342
MYH7 myosin, heavy chain 7, cardiac muscle, beta 0.663342
MYO18B myosin XVIIIB 0.663342
SMTNL1 smoothelin-like 1 0.663342
MYPN myopalladin 0.663342
TNNC2 troponin C type 2 (fast) 0.663342
TNNC1 troponin C type 1 (slow) 0.663342
MYL9 myosin, light chain 9, regulatory 0.237908
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25 0.237908
CAPN3 calpain 3, (p94) 0.237908
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 0.237908
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle 0.237908
MYL7 myosin, light chain 7, regulatory 0.237908
PDE4DIP phosphodiesterase 4D interacting protein 0.237908
KY kyphoscoliosis peptidase 0.237908
VCL vinculin 0.237908
SRI sorcin 0.237908
MYL5 myosin, light chain 5, regulatory 0.237908
MYL1 myosin, light chain 1, alkali; skeletal, fast 0.237908
MYL2 myosin, light chain 2, regulatory, cardiac, slow 0.237908
TPM4 tropomyosin 4 0.237908
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.237908
BMP10 bone morphogenetic protein 10 0.237908
HABP4 hyaluronan binding protein 4 0.237908
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 0.237908
CFL2 cofilin 2 (muscle) 0.237908
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 0.237908
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle 0.237908
NEXN nexilin (F actin binding protein) 0.237908
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.237908
MYBPC3 myosin binding protein C, cardiac 0.237908
TTN titin 0.237908
MYOM1 myomesin 1 0.237908
MYOM3 myomesin 3 0.237908
TPM1 tropomyosin 1 (alpha) 0.237908
TPM2 tropomyosin 2 (beta) 0.237908
PLEC plectin 0.237908
MYH11 myosin, heavy chain 11, smooth muscle 0.237908
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.237908
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.237908
FLNC filamin C, gamma 0.237908
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.237908
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.237908
SYNPO2 synaptopodin 2 0.237908
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 0.237908
OBSL1 obscurin-like 1 0.237908
HRC histidine rich calcium binding protein 0.237908
GCOM1 GRINL1A complex locus 1 0.237908
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 0.237908
TCAP titin-cap 0.237908
KLHL41 kelch-like family member 41 0.237908
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.237908
FKBP1B FK506 binding protein 1B, 12.6 kDa 0.237908
FKBP1A FK506 binding protein 1A, 12kDa 0.237908
TWF2 twinfilin actin binding protein 2 0.098109
MYLK2 myosin light chain kinase 2 0.098109
TWF1 twinfilin actin binding protein 1 0.098109
SCN3B sodium channel, voltage gated, type III beta subunit 0.098109
AHNAK2 AHNAK nucleoprotein 2 0.098109
SCN1A sodium channel, voltage gated, type I alpha subunit 0.098109
MYBPC1 myosin binding protein C, slow type 0.098109
CASQ2 calsequestrin 2 (cardiac muscle) 0.098109
BIN1 bridging integrator 1 0.098109
AHNAK AHNAK nucleoprotein 0.098109
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha 0.098109
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 0.098109
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.098109
PSEN2 presenilin 2 0.098109
PDE4B phosphodiesterase 4B, cAMP-specific 0.098109
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 0.098109
PSEN1 presenilin 1 0.098109
ABRA actin binding Rho activating protein 0.098109
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.098109
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.098109
RYR2 ryanodine receptor 2 (cardiac) 0.098109
MYL4 myosin, light chain 4, alkali; atrial, embryonic 0.098109
ANK2 ankyrin 2, neuronal 0.098109
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.098109
JUP junction plakoglobin 0.098109
SCN8A sodium channel, voltage gated, type VIII alpha subunit 0.098109
NPNT nephronectin 0.03318
CST3 cystatin C 0.03318
SPHKAP SPHK1 interactor, AKAP domain containing 0.03318
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 0.03318
TMOD1 tropomodulin 1 0.03318
TMOD3 tropomodulin 3 (ubiquitous) 0.03318
LRRC10 leucine rich repeat containing 10 0.03318
TMOD4 tropomodulin 4 (muscle) 0.03318
XIRP2 xin actin binding repeat containing 2 0.03318
FXR1 fragile X mental retardation, autosomal homolog 1 0.03318
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.03318
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 0.03318
SMPX small muscle protein, X-linked 0.03318
ACTN1 actinin, alpha 1 0.03318
ACTN4 actinin, alpha 4 0.03318
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.03318
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.03318
ABLIM2 actin binding LIM protein family, member 2 0.03318
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 0.03318
MURC muscle-related coiled-coil protein 0.03318
ACTA2 actin, alpha 2, smooth muscle, aorta 0.03318
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.03318
TRIM32 tripartite motif containing 32 0.03318
FHL2 four and a half LIM domains 2 0.03318
IDO1 indoleamine 2,3-dioxygenase 1 0.03318
FHL3 four and a half LIM domains 3 0.03318
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 0.03318
CMYA5 cardiomyopathy associated 5 0.03318
NRAP nebulin-related anchoring protein 0.03318
JPH1 junctophilin 1 0.03318
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 0.03318
SYNPO2L synaptopodin 2-like 0.03318
JPH2 junctophilin 2 0.03318
TIMP4 TIMP metallopeptidase inhibitor 4 0.03318
MMP2 matrix metallopeptidase 2 0.03318
MEF2C myocyte enhancer factor 2C 0.03318
KAT2B K(lysine) acetyltransferase 2B 0.03318
UTRN utrophin 0.03318
S100A1 S100 calcium binding protein A1 0.03318
MYOZ3 myozenin 3 0.03318
CAPZB capping protein (actin filament) muscle Z-line, beta 0.03318
ADRA1A adrenoceptor alpha 1A 0.03318
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 0.03318
MYOM2 myomesin 2 0.03318
TNNI1 troponin I type 1 (skeletal, slow) 0.03318
HOMER1 homer scaffolding protein 1 0.03318
KRT8 keratin 8, type II 0.03318
GJA1 gap junction protein, alpha 1, 43kDa 0.03318
MYOD1 myogenic differentiation 1 0.03318
SYNC syncoilin, intermediate filament protein 0.03318
AKAP4 A kinase (PRKA) anchor protein 4 0.03318
HDAC4 histone deacetylase 4 0.03318
ARF1 ADP-ribosylation factor 1 0.03318
GLRX3 glutaredoxin 3 0.03318
FBXO32 F-box protein 32 0.03318
CRYAB crystallin, alpha B 0.03318
ANKRD23 ankyrin repeat domain 23 0.03318
LMAN1 lectin, mannose-binding, 1 0.03318
ACTG1 actin gamma 1 0.03318
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.03318
MYL12B myosin, light chain 12B, regulatory 0.03318
BAG3 BCL2-associated athanogene 3 0.03318
HSPB1 heat shock 27kDa protein 1 0.03318
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 0.03318
SDC4 syndecan 4 0.03318