congestive heart failure Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body. (Human Disease Ontology, DOID_6000)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0001635
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Genes

220 genes associated with the congestive heart failure phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
IL1RL1 interleukin 1 receptor-like 1 2.95702
IL18RAP interleukin 18 receptor accessory protein 2.37936
IL18R1 interleukin 18 receptor 1 2.33605
SLC9A4 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 2.3201
NAT8 N-acetyltransferase 8 (GCN5-related, putative) 2.06978
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 2.04964
IL1R1 interleukin 1 receptor, type I 1.94622
IL1RL2 interleukin 1 receptor-like 2 1.85891
CTNNA3 catenin (cadherin-associated protein), alpha 3 1.1784
TPD52 tumor protein D52 1.12851
DENND1B DENN/MADD domain containing 1B 1.12851
CMTM7 CKLF-like MARVEL transmembrane domain containing 7 1.11203
CCL28 chemokine (C-C motif) ligand 28 1.09906
BNC2 basonuclin 2 1.0674
CDH15 cadherin 15, type 1, M-cadherin (myotubule) 1.05999
ICA1 islet cell autoantigen 1, 69kDa 1.04365
C15ORF54 chromosome 15 open reading frame 54 1.04365
OTUD7A OTU deubiquitinase 7A 1.04365
CADPS Ca++-dependent secretion activator 1.00059
SLCO5A1 solute carrier organic anion transporter family, member 5A1 1.00059
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 1.00059
MYO5A myosin VA (heavy chain 12, myoxin) 1.00059
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa 0.969142
FAM155A family with sequence similarity 155, member A 0.969142
NRG1 neuregulin 1 0.969142
GAS8 growth arrest-specific 8 0.954508
EGFLAM EGF-like, fibronectin type III and laminin G domains 0.948539
CNTN1 contactin 1 0.942765
GPM6A glycoprotein M6A 0.942765
PRTFDC1 phosphoribosyl transferase domain containing 1 0.942765
SLC44A3 solute carrier family 44, member 3 0.942765
COMMD10 COMM domain containing 10 0.942765
ANKRD6 ankyrin repeat domain 6 0.942765
DAP death-associated protein 0.919744
SHB Src homology 2 domain containing adaptor protein B 0.919744
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 0.899912
AAK1 AP2 associated kinase 1 0.899912
KIF13B kinesin family member 13B 0.899912
ADGRL2 adhesion G protein-coupled receptor L2 0.899912
ISM1 isthmin 1, angiogenesis inhibitor 0.882984
SORCS1 sortilin-related VPS10 domain containing receptor 1 0.882984
NUP98 nucleoporin 98kDa 0.882984
PARVA parvin, alpha 0.882984
TUBGCP3 tubulin, gamma complex associated protein 3 0.881551
RANBP17 RAN binding protein 17 0.879368
GABRP gamma-aminobutyric acid (GABA) A receptor, pi 0.873845
PRKCE protein kinase C, epsilon 0.868241
RELN reelin 0.868241
EYS eyes shut homolog (Drosophila) 0.868241
IFRD1 interferon-related developmental regulator 1 0.855449
CCDC178 coiled-coil domain containing 178 0.855449
ZNF213 zinc finger protein 213 0.855449
USP47 ubiquitin specific peptidase 47 0.84767
TRIM33 tripartite motif containing 33 0.81905
CPM carboxypeptidase M 0.81601
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 0.808534
CNGB3 cyclic nucleotide gated channel beta 3 0.726078
CNOT2 CCR4-NOT transcription complex, subunit 2 0.724872
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.710458
GPR137C G protein-coupled receptor 137C 0.708265
CPNE7 copine VII 0.686028
DBN1 drebrin 1 0.678437
SULF2 sulfatase 2 0.627736
CCNJL cyclin J-like 0.62527
GPR39 G protein-coupled receptor 39 0.602774
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.600435
FOXN3 forkhead box N3 0.594193
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.58687
SCIN scinderin 0.586726
BMP6 bone morphogenetic protein 6 0.583787
VSTM1 V-set and transmembrane domain containing 1 0.579744
ATF6 activating transcription factor 6 0.576214
TENM2 teneurin transmembrane protein 2 0.575658
TTC6 tetratricopeptide repeat domain 6 0.563675
SFSWAP splicing factor, suppressor of white-apricot family 0.562717
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.560832
PTPRD protein tyrosine phosphatase, receptor type, D 0.560064
SYNJ2 synaptojanin 2 0.557335
ARNTL aryl hydrocarbon receptor nuclear translocator-like 0.546854
LOC100129620 uncharacterized LOC100129620 0.544615
MTUS2 microtubule associated tumor suppressor candidate 2 0.543523
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.53868
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.537883
FOCAD focadhesin 0.532978
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.532978
CAMTA1 calmodulin binding transcription activator 1 0.532262
KIAA1468 KIAA1468 0.532262
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.528492
KCNU1 potassium channel, subfamily U, member 1 0.527841
LAMC3 laminin, gamma 3 0.522707
STXBP5 syntaxin binding protein 5 (tomosyn) 0.519375
UPB1 ureidopropionase, beta 0.516251
MECOM MDS1 and EVI1 complex locus 0.516251
NCOA7 nuclear receptor coactivator 7 0.515005
GPATCH2 G patch domain containing 2 0.510327
CNTN5 contactin 5 0.508929
ADCY9 adenylate cyclase 9 0.506901
CELF2 CUGBP, Elav-like family member 2 0.50495
DOCK2 dedicator of cytokinesis 2 0.503898
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 0.502461
C9ORF171 chromosome 9 open reading frame 171 0.502058
PIGN phosphatidylinositol glycan anchor biosynthesis, class N 0.501063
C7 complement component 7 0.498187
ETAA1 Ewing tumor-associated antigen 1 0.497391
ANKRD11 ankyrin repeat domain 11 0.497391
FBXL7 F-box and leucine-rich repeat protein 7 0.494694
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 0.494133
ATE1 arginyltransferase 1 0.49303
TGFBR3 transforming growth factor, beta receptor III 0.492307
TNS1 tensin 1 0.491594
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.491065
GLI3 GLI family zinc finger 3 0.489852
CLU clusterin 0.489511
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome 0.488166
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.487343
POU2AF1 POU class 2 associating factor 1 0.486693
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 0.486693
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.485988
KIRREL3 kin of IRRE like 3 (Drosophila) 0.484604
ARSG arylsulfatase G 0.482921
NTM neurotrimin 0.481287
LRRC69 leucine rich repeat containing 69 0.481287
ANO4 anoctamin 4 0.480329
DOCK8 dedicator of cytokinesis 8 0.480171
STRN3 striatin, calmodulin binding protein 3 0.4797
HCFC2 host cell factor C2 0.47725
ACO1 aconitase 1, soluble 0.476506
ANPEP alanyl (membrane) aminopeptidase 0.476211
E2F3 E2F transcription factor 3 0.475772
SERPINE3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 0.472104
BIVM basic, immunoglobulin-like variable motif containing 0.47156
CASC15 cancer susceptibility candidate 15 (non-protein coding) 0.470822
BMPER BMP binding endothelial regulator 0.470238
NLRP4 NLR family, pyrin domain containing 4 0.469948
SPEN spen family transcriptional repressor 0.467959
ATXN1 ataxin 1 0.46563
CRNKL1 crooked neck pre-mRNA splicing factor 1 0.465095
NALCN sodium leak channel, non selective 0.464962
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.461984
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 0.461481
ERICH3 glutamate-rich 3 0.460365
LMNTD1 lamin tail domain containing 1 0.460365
STXBP6 syntaxin binding protein 6 (amisyn) 0.459755
PLCL2 phospholipase C-like 2 0.458671
LOC100652894 uncharacterized LOC100652894 0.457842
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa 0.457725
DOCK9 dedicator of cytokinesis 9 0.457608
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 0.456679
KDM4C lysine (K)-specific demethylase 4C 0.456219
ADAM19 ADAM metallopeptidase domain 19 0.456105
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.455422
CDH13 cadherin 13 0.455306
SMYD3 SET and MYND domain containing 3 0.45519
NIPAL4 NIPA-like domain containing 4 0.45416
USP22 ubiquitin specific peptidase 22 0.45382
SDK1 sidekick cell adhesion molecule 1 0.453483
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 0.453147
KIAA1217 KIAA1217 0.452703
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.452261
AK5 adenylate kinase 5 0.452042
TRAPPC11 trafficking protein particle complex 11 0.452042
PPP1R9B protein phosphatase 1, regulatory subunit 9B 0.45085
ADGRE1 adhesion G protein-coupled receptor E1 0.449681
LARGE like-glycosyltransferase 0.448846
STAMBPL1 STAM binding protein-like 1 0.448639
PRDM7 PR domain containing 7 0.448022
ARHGAP15 Rho GTPase activating protein 15 0.446909
ROR1 receptor tyrosine kinase-like orphan receptor 1 0.446909
FGF14 fibroblast growth factor 14 0.446909
FHIT fragile histidine triad 0.445424
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.444071
MPPED2 metallophosphoesterase domain containing 2 0.443881
SERAC1 serine active site containing 1 0.443501
RGS5 regulator of G-protein signaling 5 0.443218
PLXDC2 plexin domain containing 2 0.442937
NXPH2 neurexophilin 2 0.442008
FRMD6 FERM domain containing 6 0.440822
AHCYL2 adenosylhomocysteinase-like 2 0.440552
PTHLH parathyroid hormone-like hormone 0.439838
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium) 0.439501
LIFR leukemia inhibitory factor receptor alpha 0.438513
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.437102
LYST lysosomal trafficking regulator 0.436883
RHBDL1 rhomboid, veinlet-like 1 (Drosophila) 0.436303
DCLK2 doublecortin-like kinase 2 0.436159
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.435873
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 0.435163
RASGEF1C RasGEF domain family, member 1C 0.434186
AKAP7 A kinase (PRKA) anchor protein 7 0.433705
TRAPPC9 trafficking protein particle complex 9 0.432488
OSM oncostatin M 0.431956
MOB3B MOB kinase activator 3B 0.431235
GRID2 glutamate receptor, ionotropic, delta 2 0.431105
GAP43 growth associated protein 43 0.430781
SRFBP1 serum response factor binding protein 1 0.429822
NLRP9 NLR family, pyrin domain containing 9 0.429318
STK32A serine/threonine kinase 32A 0.428881
DCBLD1 discoidin, CUB and LCCL domain containing 1 0.428695
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 0.428633
SYCP1 synaptonemal complex protein 1 0.428571
NVL nuclear VCP-like 0.428386
AATK apoptosis-associated tyrosine kinase 0.427958
JADE2 jade family PHD finger 2 0.427958
RCL1 RNA terminal phosphate cyclase-like 1 0.427897
SDF2L1 stromal cell-derived factor 2-like 1 0.427897
DLG2 discs, large homolog 2 (Drosophila) 0.426753
SLC35F1 solute carrier family 35, member F1 0.426634
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.426634
ANK2 ankyrin 2, neuronal 0.426515
CCDC108 coiled-coil domain containing 108 0.426279
IQSEC3 IQ motif and Sec7 domain 3 0.426221
MYO16 myosin XVI 0.426181
FAM135B family with sequence similarity 135, member B 0.426141
MUC16 mucin 16, cell surface associated 0.425507
TBC1D5 TBC1 domain family, member 5 0.425233
SHC4 SHC (Src homology 2 domain containing) family, member 4 0.425233
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 0.425155
VWA3B von Willebrand factor A domain containing 3B 0.425117
CDH10 cadherin 10, type 2 (T2-cadherin) 0.424349
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.424235