complete embryonic lethality before implantation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5) (Mammalian Phenotype Ontology, MP_0011094)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0011094
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Genes

122 gene mutations causing the complete embryonic lethality before implantation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
A1CF APOBEC1 complementation factor
AATF apoptosis antagonizing transcription factor
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
AP1G1 adaptor-related protein complex 1, gamma 1 subunit
AP2M1 adaptor-related protein complex 2, mu 1 subunit
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
AURKA aurora kinase A
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
BIRC5 baculoviral IAP repeat containing 5
BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit
C9ORF114 chromosome 9 open reading frame 114
CAPN2 calpain 2, (m/II) large subunit
CAPN5 calpain 5
CASP8AP2 caspase 8 associated protein 2
CCNK cyclin K
CCNT2 cyclin T2
CDC20 cell division cycle 20
CDC73 cell division cycle 73
CDCA8 cell division cycle associated 8
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CDK11A cyclin-dependent kinase 11A
CDK8 cyclin-dependent kinase 8
CDX2 caudal type homeobox 2
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3
CHEK1 checkpoint kinase 1
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTTN cortactin
DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
DMAP1 DNA methyltransferase 1 associated protein 1
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DSC3 desmocollin 3
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECT2 epithelial cell transforming 2
EIF6 eukaryotic translation initiation factor 6
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ENDOG endonuclease G
EOMES eomesodermin
ERCC2 excision repair cross-complementation group 2
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2
EVX1 even-skipped homeobox 1
FAF1 Fas (TNFRSF6) associated factor 1
FASN fatty acid synthase
FBL fibrillarin
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
G2E3 G2/M-phase specific E3 ubiquitin protein ligase
GGN gametogenetin
GLI3 GLI family zinc finger 3
GMNN geminin, DNA replication inhibitor
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
HNRNPL heterogeneous nuclear ribonucleoprotein L
HSBP1 heat shock factor binding protein 1
INTS1 integrator complex subunit 1
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF5 Kruppel-like factor 5 (intestinal)
KMT2A lysine (K)-specific methyltransferase 2A
LIMS1 LIM and senescent cell antigen-like domains 1
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MED21 mediator complex subunit 21
NASP nuclear autoantigenic sperm protein (histone-binding)
NUP214 nucleoporin 214kDa
ODF2 outer dense fiber of sperm tails 2
PCNA proliferating cell nuclear antigen
PCSK1 proprotein convertase subtilisin/kexin type 1
PCYT1A phosphate cytidylyltransferase 1, choline, alpha
PDCD2 programmed cell death 2
PES1 pescadillo ribosomal biogenesis factor 1
PFN1 profilin 1
PIKFYVE phosphoinositide kinase, FYVE finger containing
PLA2G3 phospholipase A2, group III
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLK1 polo-like kinase 1
PLRG1 pleiotropic regulator 1
PNN pinin, desmosome associated protein
POMT2 protein-O-mannosyltransferase 2
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator
PRPF19 pre-mRNA processing factor 19
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
RACGAP1 Rac GTPase activating protein 1
RAD51 RAD51 recombinase
RBBP8 retinoblastoma binding protein 8
RBM19 RNA binding motif protein 19
RFX1 regulatory factor X, 1 (influences HLA class II expression)
RGS14 regulator of G-protein signaling 14
RPA1 replication protein A1, 70kDa
RPS19 ribosomal protein S19
RPSA ribosomal protein SA
SALL4 spalt-like transcription factor 4
SEC24D SEC24 family member D
SETD8 SET domain containing (lysine methyltransferase) 8
SF3B1 splicing factor 3b, subunit 1, 155kDa
SKIL SKI-like proto-oncogene
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMN1 survival of motor neuron 1, telomeric
SNAP23 synaptosomal-associated protein, 23kDa
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SRSF3 serine/arginine-rich splicing factor 3
TAF8 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
TEAD4 TEA domain family member 4
TIMM23 translocase of inner mitochondrial membrane 23 homolog (yeast)
TKT transketolase
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TOP1 topoisomerase (DNA) I
TOPBP1 topoisomerase (DNA) II binding protein 1
TPM3 tropomyosin 3
TRRAP transformation/transcription domain-associated protein
TTYH1 tweety family member 1
TUBG1 tubulin, gamma 1
TYR tyrosinase
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative)
UROS uroporphyrinogen III synthase
VCP valosin containing protein
WDR36 WD repeat domain 36
XAB2 XPA binding protein 2
ZNF335 zinc finger protein 335
ZNF830 zinc finger protein 830