collagen type i trimer Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A collagen trimer containing alpha(I) chains. The most common form of type I collagen is a heterotrimer containing two alpha1(I) chains and one alpha2(I) chain; homotrimers containing three alpha1(I) chains are also found. Type I collagen triple helices associate to form banded fibrils. (Gene Ontology, GO_0005584)
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Genes

218 proteins co-occuring with the collagen type i trimer cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
BGLAP bone gamma-carboxyglutamate (gla) protein 2.62517
FN1 fibronectin 1 2.36174
ALPL alkaline phosphatase, liver/bone/kidney 2.13841
ALPPL2 alkaline phosphatase, placental-like 2 2.13768
ALPP alkaline phosphatase, placental 2.13622
SPP1 secreted phosphoprotein 1 2.02132
ACAN aggrecan 2.0134
TGFB1 transforming growth factor, beta 1 1.80573
RUNX2 runt-related transcription factor 2 1.74829
MMP1 matrix metallopeptidase 1 1.73184
DCN decorin 1.70939
IBSP integrin-binding sialoprotein 1.70878
COL1A1 collagen, type I, alpha 1 1.67568
MMP2 matrix metallopeptidase 2 1.65032
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 1.49493
TIMP1 TIMP metallopeptidase inhibitor 1 1.4921
MMP13 matrix metallopeptidase 13 1.42598
BMP2 bone morphogenetic protein 2 1.42204
BGN biglycan 1.37575
CTGF connective tissue growth factor 1.34392
COL1A2 collagen, type I, alpha 2 1.3325
SP7 Sp7 transcription factor 1.31519
TNC tenascin C 1.25443
SOX9 SRY (sex determining region Y)-box 9 1.23348
MMP9 matrix metallopeptidase 9 1.22672
VCAN versican 1.21738
COMP cartilage oligomeric matrix protein 1.15928
FGF2 fibroblast growth factor 2 (basic) 1.13574
SMAD2 SMAD family member 2 1.12807
BMP7 bone morphogenetic protein 7 1.11888
SEBOX SEBOX homeobox 1.11378
DSPP dentin sialophosphoprotein 1.10103
TNMD tenomodulin 1.0741
TIMP2 TIMP metallopeptidase inhibitor 2 1.066
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 1.03078
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.02779
IVD isovaleryl-CoA dehydrogenase 0.990247
MMP3 matrix metallopeptidase 3 0.983419
PTH parathyroid hormone 0.976619
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.954483
TGFB3 transforming growth factor, beta 3 0.95305
IGF1 insulin-like growth factor 1 (somatomedin C) 0.887936
CD44 CD44 molecule (Indian blood group) 0.866287
VWF von Willebrand factor 0.845155
ALB albumin 0.844696
MMP8 matrix metallopeptidase 8 0.830925
TGFB2 transforming growth factor, beta 2 0.830007
CTHRC1 collagen triple helix repeat containing 1 0.817616
SMAD3 SMAD family member 3 0.815322
FMOD fibromodulin 0.813028
ACE angiotensin I converting enzyme 0.805689
LUM lumican 0.772275
ELN elastin 0.756345
GDF6 growth differentiation factor 6 0.748189
COL3A1 collagen, type III, alpha 1 0.745025
IL6 interleukin 6 0.742318
SMAD7 SMAD family member 7 0.741867
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.740965
BMP4 bone morphogenetic protein 4 0.738713
LOX lysyl oxidase 0.735115
DDR2 discoidin domain receptor tyrosine kinase 2 0.71457
PDGFB platelet-derived growth factor beta polypeptide 0.710136
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.699983
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 0.692078
COL2A1 collagen, type II, alpha 1 0.684644
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.684207
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.675065
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.671593
CRTAP cartilage associated protein 0.66726
COL10A1 collagen, type X, alpha 1 0.65905
VEGFA vascular endothelial growth factor A 0.636723
TIMP4 TIMP metallopeptidase inhibitor 4 0.632024
TIMP3 TIMP metallopeptidase inhibitor 3 0.631598
BMP1 bone morphogenetic protein 1 0.626483
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.626483
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 0.622654
DDR1 discoidin domain receptor tyrosine kinase 1 0.604862
GDF7 growth differentiation factor 7 0.601487
CD68 CD68 molecule 0.596014
CTSK cathepsin K 0.595593
EDA ectodysplasin A 0.593912
IL1B interleukin 1, beta 0.586361
P3H1 prolyl 3-hydroxylase 1 0.565508
FGF1 fibroblast growth factor 1 (acidic) 0.559285
KERA keratocan 0.558457
TNF tumor necrosis factor 0.553905
THY1 Thy-1 cell surface antigen 0.547297
NOV nephroblastoma overexpressed 0.543587
PTHLH parathyroid hormone-like hormone 0.530438
DMP1 dentin matrix acidic phosphoprotein 1 0.519389
CD34 CD34 molecule 0.51164
DLX5 distal-less homeobox 5 0.508383
ACPP acid phosphatase, prostate 0.500664
ACTB actin, beta 0.491752
ITGA1 integrin, alpha 1 0.485289
ACTG1 actin gamma 1 0.464397
AGTR1 angiotensin II receptor, type 1 0.4608
MGP matrix Gla protein 0.4608
HHIPL2 HHIP-like 2 0.455214
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.453223
FBN1 fibrillin 1 0.449245
TGFBR1 transforming growth factor, beta receptor 1 0.44052
SOST sclerostin 0.435775
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.430647
MUL1 mitochondrial E3 ubiquitin protein ligase 1 0.427104
COL14A1 collagen, type XIV, alpha 1 0.425531
IHH indian hedgehog 0.421212
PPARG peroxisome proliferator-activated receptor gamma 0.417685
BMP6 bone morphogenetic protein 6 0.417685
AMBN ameloblastin (enamel matrix protein) 0.410649
PRG4 proteoglycan 4 0.409869
PCNA proliferating cell nuclear antigen 0.409869
HBA1 hemoglobin, alpha 1 0.39626
HAS2 hyaluronan synthase 2 0.391615
HBA2 hemoglobin, alpha 2 0.390455
PCOLCE procollagen C-endopeptidase enhancer 0.37505
VCL vinculin 0.373899
INS insulin 0.373516
CMA1 chymase 1, mast cell 0.37045
RFX5 regulatory factor X, 5 (influences HLA class II expression) 0.368919
SMAD5 SMAD family member 5 0.367388
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 0.367006
GP6 glycoprotein VI (platelet) 0.362804
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.360515
ACTA1 actin, alpha 1, skeletal muscle 0.35899
NR3C2 nuclear receptor subfamily 3, group C, member 2 0.358609
POSTN periostin, osteoblast specific factor 0.350243
JUN jun proto-oncogene 0.347967
IFNA6 interferon, alpha 6 0.346829
CXCL12 chemokine (C-X-C motif) ligand 12 0.343042
VCAM1 vascular cell adhesion molecule 1 0.327581
CCL2 chemokine (C-C motif) ligand 2 0.32345
SMAD4 SMAD family member 4 0.320451
SDC2 syndecan 2 0.312224
GDF5 growth differentiation factor 5 0.311478
S100A4 S100 calcium binding protein A4 0.308122
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.30626
NANOG Nanog homeobox 0.303283
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.30254
TNNC1 troponin C type 1 (slow) 0.301054
GDF2 growth differentiation factor 2 0.299569
TRAM2 translocation associated membrane protein 2 0.297713
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.297342
NPPA natriuretic peptide A 0.281453
IL13 interleukin 13 0.279612
LGALS3 lectin, galactoside-binding, soluble, 3 0.278509
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.275936
MMP7 matrix metallopeptidase 7 0.274835
POLR2H polymerase (RNA) II (DNA directed) polypeptide H 0.272267
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 0.268603
PCOLCE2 procollagen C-endopeptidase enhancer 2 0.264946
GJA1 gap junction protein, alpha 1, 43kDa 0.264581
EDN1 endothelin 1 0.26312
SOX5 SRY (sex determining region Y)-box 5 0.26239
FOXF1 forkhead box F1 0.262025
WISP2 WNT1 inducible signaling pathway protein 2 0.262025
PAX1 paired box 1 0.259837
PRELP proline/arginine-rich end leucine-rich repeat protein 0.257652
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 0.256561
BUD31 BUD31 homolog (S. cerevisiae) 0.255834
F8 coagulation factor VIII, procoagulant component 0.252927
GREM1 gremlin 1, DAN family BMP antagonist 0.252927
WISP3 WNT1 inducible signaling pathway protein 3 0.249664
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.240996
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.240996
ACE2 angiotensin I converting enzyme 2 0.240636
TSPO translocator protein (18kDa) 0.239916
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.237401
TERT telomerase reverse transcriptase 0.237042
FGF7 fibroblast growth factor 7 0.234891
CHAD chondroadherin 0.234174
IL1A interleukin 1, alpha 0.232386
IGFBP3 insulin-like growth factor binding protein 3 0.228108
LEP leptin 0.228108
MEPE matrix extracellular phosphoglycoprotein 0.227752
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 0.225976
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 0.22279
ICAM1 intercellular adhesion molecule 1 0.222083
PCBP3 poly(rC) binding protein 3 0.22173
IGFBP5 insulin-like growth factor binding protein 5 0.221378
MCAM melanoma cell adhesion molecule 0.221378
CALCR calcitonin receptor 0.220673
SHOX2 short stature homeobox 2 0.219969
KRT10 keratin 10, type I 0.217861
CSN1S1 casein alpha s1 0.214366
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.21228
FBLN2 fibulin 2 0.210894
MPHOSPH9 M-phase phosphoprotein 9 0.209513
SIN3B SIN3 transcription regulator family member B 0.208137
MAPK3 mitogen-activated protein kinase 3 0.203022
SCX scleraxis basic helix-loop-helix transcription factor 0.200328
AMELX amelogenin, X-linked 0.196669
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.19601
MGAM maltase-glucoamylase 0.19307
PLG plasminogen 0.191456
ERAS ES cell expressed Ras 0.191456
AMELY amelogenin, Y-linked 0.190814
FKBP10 FK506 binding protein 10, 65 kDa 0.190175
MIA melanoma inhibitory activity 0.189222
PLAU plasminogen activator, urokinase 0.188905
CD36 CD36 molecule (thrombospondin receptor) 0.18859
PLCL1 phospholipase C-like 1 0.18796
NMUR1 neuromedin U receptor 1 0.183328
FOS FBJ murine osteosarcoma viral oncogene homolog 0.183328
CIITA class II, major histocompatibility complex, transactivator 0.182723
MMP12 matrix metallopeptidase 12 0.177439
HEMGN hemogen 0.177154
DGKZ diacylglycerol kinase, zeta 0.172468
FBRS fibrosin 0.171149
CXCL8 chemokine (C-X-C motif) ligand 8 0.165932
CRP C-reactive protein, pentraxin-related 0.163865
CEMP1 cementum protein 1 0.160863
ILK integrin-linked kinase 0.160658
TWIST2 twist family bHLH transcription factor 2 0.160456
MMP16 matrix metallopeptidase 16 (membrane-inserted) 0.160053
PTH1R parathyroid hormone 1 receptor 0.159658
FABP4 fatty acid binding protein 4, adipocyte 0.15776
SLC39A13 solute carrier family 39 (zinc transporter), member 13 0.156513