cocaine abuse Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A substance abuse that involves the recurring use of cocaine despite negative consequences. (Human Disease Ontology, DOID_809)
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Genes

122 genes co-occuring with the disease cocaine abuse in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.62157
MOBP myelin-associated oligodendrocyte basic protein 1.52116
INTS8 integrator complex subunit 8 1.31319
BCHE butyrylcholinesterase 1.3062
COCH cochlin 1.24689
DRD2 dopamine receptor D2 1.22822
OPRM1 opioid receptor, mu 1 1.10973
DMAP1 DNA methyltransferase 1 associated protein 1 1.05261
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 1.0206
CRIP2 cysteine-rich protein 2 1.01427
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 0.963728
TRDMT1 tRNA aspartic acid methyltransferase 1 0.94369
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 0.928759
TAAR1 trace amine associated receptor 1 0.919673
PDYN prodynorphin 0.915139
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 0.883521
PTK2 protein tyrosine kinase 2 0.877786
CRH corticotropin releasing hormone 0.8741
DRD3 dopamine receptor D3 0.873281
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 0.847898
ADRBK2 adrenergic, beta, receptor kinase 2 0.831918
RNMT RNA (guanine-7-) methyltransferase 0.803616
CHURC1 churchill domain containing 1 0.777386
DRD1 dopamine receptor D1 0.759008
NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing 0.755749
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 0.749644
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 0.745172
LAMB1 laminin, beta 1 0.73746
PLP1 proteolipid protein 1 0.733001
HTN3 histatin 3 0.722886
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.705547
POMC proopiomelanocortin 0.676706
AKTIP AKT interacting protein 0.669936
CNOT2 CCR4-NOT transcription complex, subunit 2 0.657234
GRM5 glutamate receptor, metabotropic 5 0.656441
PRTN3 proteinase 3 0.656046
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.65288
CCKAR cholecystokinin A receptor 0.650113
CLMP CXADR-like membrane protein 0.641827
PRDX2 peroxiredoxin 2 0.640251
BTC betacellulin 0.636708
CARTPT CART prepropeptide 0.621008
SLC4A11 solute carrier family 4, sodium borate transporter, member 11 0.594843
ADRA2C adrenoceptor alpha 2C 0.576939
CCKBR cholecystokinin B receptor 0.568386
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 0.567997
THRSP thyroid hormone responsive 0.552463
ANKK1 ankyrin repeat and kinase domain containing 1 0.545093
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 0.534248
KLHL17 kelch-like family member 17 0.516879
DRD4 dopamine receptor D4 0.513033
PCDH8 protocadherin 8 0.506507
GRIK1 glutamate receptor, ionotropic, kainate 1 0.483985
CRHR1 corticotropin releasing hormone receptor 1 0.471846
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.468819
HINT1 histidine triad nucleotide binding protein 1 0.467306
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 0.465038
MAOB monoamine oxidase B 0.459751
OXT oxytocin/neurophysin I prepropeptide 0.454847
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.453716
HDAC2 histone deacetylase 2 0.452962
ITGB6 integrin, beta 6 0.443547
ETFA electron-transfer-flavoprotein, alpha polypeptide 0.442042
GRAP2 GRB2-related adaptor protein 2 0.437906
SOX3 SRY (sex determining region Y)-box 3 0.437906
NPSR1 neuropeptide S receptor 1 0.42589
PCYT1A phosphate cytidylyltransferase 1, choline, alpha 0.42214
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 0.41465
HESX1 HESX homeobox 1 0.414276
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 0.404184
DPYSL2 dihydropyrimidinase-like 2 0.388166
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 0.387051
NRGN neurogranin (protein kinase C substrate, RC3) 0.383708
VKORC1 vitamin K epoxide reductase complex, subunit 1 0.38111
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 0.377031
MAGEC1 melanoma antigen family C1 0.375179
PITX3 paired-like homeodomain 3 0.373328
CLDN11 claudin 11 0.365932
PVALB parvalbumin 0.355972
RECK reversion-inducing-cysteine-rich protein with kazal motifs 0.350452
ALCAM activated leukocyte cell adhesion molecule 0.347144
SOCS3 suppressor of cytokine signaling 3 0.329565
SNCB synuclein, beta 0.32701
PRL prolactin 0.324823
OTX2 orthodenticle homeobox 2 0.323002
NR1I3 nuclear receptor subfamily 1, group I, member 3 0.312464
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 0.304503
EPHB4 EPH receptor B4 0.30342
GRM2 glutamate receptor, metabotropic 2 0.299092
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.28831
SARS seryl-tRNA synthetase 0.283297
EMP1 epithelial membrane protein 1 0.278654
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.27687
NPS neuropeptide S 0.273664
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 0.271174
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 0.270108
NTS neurotensin 0.267622
MGP matrix Gla protein 0.26266
CYP2D7 cytochrome P450, family 2, subfamily D, polypeptide 7 (gene/pseudogene) 0.251718
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 0.242245
MBP myelin basic protein 0.240847
FBXO17 F-box protein 17 0.240497
ADCY2 adenylate cyclase 2 (brain) 0.22454
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.21974
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 0.213621
NGF nerve growth factor (beta polypeptide) 0.212608
TKT transketolase 0.211261
GRM1 glutamate receptor, metabotropic 1 0.194548
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.192344
CORT cortistatin 0.191097
PSENEN presenilin enhancer gamma secretase subunit 0.189551
FH fumarate hydratase 0.189244
UCN urocortin 0.180937
CCK cholecystokinin 0.179239
CREB1 cAMP responsive element binding protein 1 0.177576
ACHE acetylcholinesterase (Yt blood group) 0.176757
SOX10 SRY (sex determining region Y)-box 10 0.172291
GPX5 glutathione peroxidase 5 0.170789
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.169091
GPX4 glutathione peroxidase 4 0.168617
OR10T2 olfactory receptor, family 10, subfamily T, member 2 0.165217
GPX1 glutathione peroxidase 1 0.160203