climbing fiber Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description The axon of inferior olive neuron that projects to the cerebellar cortex, largely via the inferior cerebellar peduncle. They range in diameter from 1-3 um and are myelinated until they enter the granule cell layer. They give off collaterals to the deep cerebellar nuclei. They synapse extensively with the dendrites of Purkinje cells in the molecular layer, where each fiber branches repeatedly to climb along the Purkinje cell dendritic tree. Each Purkinje cell is innervated by only a single climbing fiber. (Gene Ontology, GO_0044301)
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Genes

127 proteins co-occuring with the climbing fiber cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
GRM1 glutamate receptor, metabotropic 1 1.90077
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 1.65453
GRID2 glutamate receptor, ionotropic, delta 2 1.59083
CRH corticotropin releasing hormone 1.52541
OLIG3 oligodendrocyte transcription factor 3 1.4069
CALB1 calbindin 1, 28kDa 1.37464
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 1.31088
PTF1A pancreas specific transcription factor, 1a 1.25022
PLCB4 phospholipase C, beta 4 1.10919
CBLN1 cerebellin 1 precursor 1.07663
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 1.06347
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 1.00991
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3 0.977589
DAGLB diacylglycerol lipase, beta 0.929833
ATCAY ataxia, cerebellar, Cayman type 0.925135
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.878712
CALB2 calbindin 2 0.868126
ABHD12 abhydrolase domain containing 12 0.838728
DNER delta/notch-like EGF repeat containing 0.83781
GLUD2 glutamate dehydrogenase 2 0.824959
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 0.81257
GJD2 gap junction protein, delta 2, 36kDa 0.797895
CNR1 cannabinoid receptor 1 (brain) 0.797436
ATOH1 atonal homolog 1 (Drosophila) 0.793771
DSE dermatan sulfate epimerase 0.766349
PVALB parvalbumin 0.75453
RORA RAR-related orphan receptor A 0.726599
EBF2 early B-cell factor 2 0.711022
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa 0.707482
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) 0.706598
ABHD6 abhydrolase domain containing 6 0.701304
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.696465
MED12 mediator complex subunit 12 0.695148
PRIMA1 proline rich membrane anchor 1 0.682463
DAGLA diacylglycerol lipase, alpha 0.673328
CALCA calcitonin-related polypeptide alpha 0.670725
NENF neudesin neurotrophic factor 0.666827
MGLL monoglyceride lipase 0.66164
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.639717
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.637578
NTF4 neurotrophin 4 0.634586
COX5A cytochrome c oxidase subunit Va 0.630318
CRHR1 corticotropin releasing hormone receptor 1 0.629892
BDNF brain-derived neurotrophic factor 0.615861
SCN8A sodium channel, voltage gated, type VIII alpha subunit 0.600223
FOXD3 forkhead box D3 0.600223
DPF1 D4, zinc and double PHD fingers family 1 0.59896
GRIA4 glutamate receptor, ionotropic, AMPA 4 0.597697
SCG2 secretogranin II 0.588456
ASTN1 astrotactin 1 0.586361
MOB4 MOB family member 4, phocein 0.585105
STRN4 striatin, calmodulin binding protein 4 0.580504
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.576329
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10 0.54771
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.542764
CALCB calcitonin-related polypeptide beta 0.536183
DAB2IP DAB2 interacting protein 0.528798
LBX1 ladybird homeobox 1 0.5149
GRM2 glutamate receptor, metabotropic 2 0.509197
GRIA2 glutamate receptor, ionotropic, AMPA 2 0.50107
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C) 0.498231
GRIA3 glutamate receptor, ionotropic, AMPA 3 0.495395
ARC activity-regulated cytoskeleton-associated protein 0.490539
ATXN1 ataxin 1 0.486096
ICA1 islet cell autoantigen 1, 69kDa 0.481661
NPS neuropeptide S 0.479647
GDF7 growth differentiation factor 7 0.425138
GRIK1 glutamate receptor, ionotropic, kainate 1 0.419252
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.415337
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.408699
LMX1A LIM homeobox transcription factor 1, alpha 0.407529
GBX2 gastrulation brain homeobox 2 0.404415
CCK cholecystokinin 0.368536
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like 0.361659
KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4 0.360133
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 0.355563
CDO1 cysteine dioxygenase type 1 0.351002
TH tyrosine hydroxylase 0.347587
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.340773
IGF1 insulin-like growth factor 1 (somatomedin C) 0.335864
NRCAM neuronal cell adhesion molecule 0.334356
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.330966
CSAD cysteine sulfinic acid decarboxylase 0.319702
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.308494
WNT1 wingless-type MMTV integration site family, member 1 0.305888
CNTN2 contactin 2 (axonal) 0.302168
SHKBP1 SH3KBP1 binding protein 1 0.29994
PDE1A phosphodiesterase 1A, calmodulin-dependent 0.297342
CA10 carbonic anhydrase X 0.275569
GNS glucosamine (N-acetyl)-6-sulfatase 0.267871
STRN striatin, calmodulin binding protein 0.265311
NEUROG1 neurogenin 1 0.262755
CHGB chromogranin B 0.26166
ACHE acetylcholinesterase (Yt blood group) 0.256197
TRPC3 transient receptor potential cation channel, subfamily C, member 3 0.253653
NT5E 5'-nucleotidase, ecto (CD73) 0.252927
NLGN2 neuroligin 2 0.252564
CARTPT CART prepropeptide 0.248216
CAMK4 calcium/calmodulin-dependent protein kinase IV 0.246769
PCCA propionyl CoA carboxylase, alpha polypeptide 0.243158
RELN reelin 0.236324
GPHN gephyrin 0.232029
UCN urocortin 0.229532
CRHR2 corticotropin releasing hormone receptor 2 0.228819
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.228464
POU4F1 POU class 4 homeobox 1 0.205059
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.203699
TARP TCR gamma alternate reading frame protein 0.200999
HCRT hypocretin (orexin) neuropeptide precursor 0.197993
PEX2 peroxisomal biogenesis factor 2 0.195681
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 0.194698
FOXL2 forkhead box L2 0.190814
ATXN7 ataxin 7 0.189222
GRASP GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein 0.181823
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.177439
FADS1 fatty acid desaturase 1 0.17687
RICTOR RPTOR independent companion of MTOR, complex 2 0.175745
RBM10 RNA binding motif protein 10 0.175466
TNR tenascin R 0.168598
TJP1 tight junction protein 1 0.167366
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 0.164315
RIMS1 regulating synaptic membrane exocytosis 1 0.16298
ADO 2-aminoethanethiol (cysteamine) dioxygenase 0.16298
HES5 hes family bHLH transcription factor 5 0.160456
ELL elongation factor RNA polymerase II 0.160456
OTX2 orthodenticle homeobox 2 0.159268
ESPN espin 0.158692