cleavage furrow Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description In animal cells, the first sign of cleavage, or cytokinesis, is the appearance of a shallow groove in the cell surface near the old metaphase plate. A contractile ring containing actin and myosin is located just inside the plasma membrane at the location of the furrow. Ring contraction is associated with centripetal growth of the membrane that deepens the cleavage furrow and divides the cytoplasm of the two daughter cells. While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists. (Gene Ontology, GO_0032154)
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Genes

176 proteins co-occuring with the cleavage furrow cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
ANLN anillin, actin binding protein 1.93065
ECT2 epithelial cell transforming 2 1.69216
RACGAP1 Rac GTPase activating protein 1 1.52484
SEPT5 septin 5 1.30766
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6 1.30551
KIF23 kinesin family member 23 1.27877
AURKB aurora kinase B 1.19931
KIF20A kinesin family member 20A 1.1475
INCENP inner centromere protein antigens 135/155kDa 1.14597
KIF14 kinesin family member 14 1.13523
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 1.12245
PLK1 polo-like kinase 1 1.11531
RDX radixin 1.01288
KIF12 kinesin family member 12 0.980501
PRC1 protein regulator of cytokinesis 1 0.923259
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.890707
CEP126 centrosomal protein 126kDa 0.881016
SEPT2 septin 2 0.874567
MSN moesin 0.835515
EZR ezrin 0.810735
CDK1 cyclin-dependent kinase 1 0.806148
KRT4 keratin 4, type II 0.760433
FMN1 formin 1 0.749094
RAB11FIP3 RAB11 family interacting protein 3 (class II) 0.739614
NUDC nudC nuclear distribution protein 0.733319
SEPT1 septin 1 0.725705
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) 0.711465
LIMA1 LIM domain and actin binding 1 0.699103
ARF6 ADP-ribosylation factor 6 0.696905
ALKBH4 alkB, alkylation repair homolog 4 (E. coli) 0.680284
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 0.672894
DIAPH3 diaphanous-related formin 3 0.664664
ARHGAP35 Rho GTPase activating protein 35 0.659482
STARD9 StAR-related lipid transfer (START) domain containing 9 0.654311
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 0.646145
KIF20B kinesin family member 20B 0.629039
CEP55 centrosomal protein 55kDa 0.625206
SMR3B submaxillary gland androgen regulated protein 3B 0.616709
MASTL microtubule associated serine/threonine kinase-like 0.612471
MOB1B MOB kinase activator 1B 0.611625
SVIL supervillin 0.604862
FSCN1 fascin actin-bundling protein 1 0.601066
ARHGAP1 Rho GTPase activating protein 1 0.596014
MYLK myosin light chain kinase 0.593492
SPIRE1 spire-type actin nucleation factor 1 0.590133
HMCN1 hemicentin 1 0.575912
TUBA1A tubulin, alpha 1a 0.557214
NANOS1 nanos homolog 1 (Drosophila) 0.550186
KIF2B kinesin family member 2B 0.548947
MOB1A MOB kinase activator 1A 0.548535
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived) 0.547297
STRN4 striatin, calmodulin binding protein 4 0.544411
SPIRE2 spire-type actin nucleation factor 2 0.54194
UNC45A unc-45 homolog A (C. elegans) 0.539472
KLHL2 kelch-like family member 2 0.53906
LIMK2 LIM domain kinase 2 0.501476
PPME1 protein phosphatase methylesterase 1 0.499447
IFT27 intraflagellar transport 27 0.480855
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.477233
LIMK1 LIM domain kinase 1 0.476831
LCMT1 leucine carboxyl methyltransferase 1 0.471609
CSPP1 centrosome and spindle pole associated protein 1 0.459203
MIF4GD MIF4G domain containing 0.456809
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.454418
MARK2 MAP/microtubule affinity-regulating kinase 2 0.448848
MELK maternal embryonic leucine zipper kinase 0.444482
FYN FYN proto-oncogene, Src family tyrosine kinase 0.441312
STK24 serine/threonine kinase 24 0.44052
DES desmin 0.423174
KIF2C kinesin family member 2C 0.419644
IFT46 intraflagellar transport 46 0.419252
FSCN3 fascin actin-bundling protein 3, testicular 0.415728
EXOC2 exocyst complex component 2 0.407919
PFN2 profilin 2 0.404026
FSCN2 fascin actin-bundling protein 2, retinal 0.401693
DCTN1 dynactin 1 0.400527
TUBD1 tubulin, delta 1 0.392001
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.391615
PFN1 profilin 1 0.386979
ALMS1 Alstrom syndrome protein 1 0.386593
BAIAP2L1 BAI1-associated protein 2-like 1 0.385822
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.385051
GPR182 G protein-coupled receptor 182 0.385051
SKA3 spindle and kinetochore associated complex subunit 3 0.383509
WDR62 WD repeat domain 62 0.382739
CAMLG calcium modulating ligand 0.378891
ARHGAP18 Rho GTPase activating protein 18 0.376202
SH3PXD2A SH3 and PX domains 2A 0.376202
STARD13 StAR-related lipid transfer (START) domain containing 13 0.374666
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4 0.373132
KIF4A kinesin family member 4A 0.372366
EXOC7 exocyst complex component 7 0.371216
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A 0.370067
TUBE1 tubulin, epsilon 1 0.367388
LGALS13 lectin, galactoside-binding, soluble, 13 0.353662
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.350622
CDC42 cell division cycle 42 0.349863
KIFC3 kinesin family member C3 0.347208
IQGAP2 IQ motif containing GTPase activating protein 2 0.338506
PI4KB phosphatidylinositol 4-kinase, catalytic, beta 0.337373
VILL villin-like 0.329461
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 0.324576
TMSB4X thymosin beta 4, X-linked 0.318205
CD2AP CD2-associated protein 0.317082
SEPT3 septin 3 0.315212
PARD3 par-3 family cell polarity regulator 0.313718
RAB21 RAB21, member RAS oncogene family 0.312597
SEPT7 septin 7 0.312597
NCBP1 nuclear cap binding protein subunit 1, 80kDa 0.311105
GFAP glial fibrillary acidic protein 0.304399
INSC inscuteable homolog (Drosophila) 0.303283
PKP4 plakophilin 4 0.302912
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.296972
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.295119
PFN4 profilin family, member 4 0.293267
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 0.292527
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome 0.290308
FLNA filamin A, alpha 0.289199
APITD1 apoptosis-inducing, TAF9-like domain 1 0.288091
WDR1 WD repeat domain 1 0.287721
RND2 Rho family GTPase 2 0.286614
SPTBN2 spectrin, beta, non-erythrocytic 2 0.285507
MYO1A myosin IA 0.284769
MINK1 misshapen-like kinase 1 0.279612
NUMA1 nuclear mitotic apparatus protein 1 0.277406
CRMP1 collapsin response mediator protein 1 0.276304
SRI sorcin 0.274835
CCNB1 cyclin B1 0.274468
RAB11A RAB11A, member RAS oncogene family 0.264581
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.252202
STK25 serine/threonine kinase 25 0.24894
FMN2 formin 2 0.247854
KIF15 kinesin family member 15 0.246769
STIL SCL/TAL1 interrupting locus 0.245323
PLS1 plastin 1 0.24424
DNM2 dynamin 2 0.236324
ODF2 outer dense fiber of sperm tails 2 0.233101
EXOC5 exocyst complex component 5 0.216111
SSH1 slingshot protein phosphatase 1 0.214366
ARF4 ADP-ribosylation factor 4 0.211587
OCA2 oculocutaneous albinism II 0.209858
RTKN rhotekin 0.205399
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 0.205059
CLIP1 CAP-GLY domain containing linker protein 1 0.203699
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 0.200663
SPN sialophorin 0.200663
DCXR dicarbonyl/L-xylulose reductase 0.199659
AXIN1 axin 1 0.199325
CTNND2 catenin (cadherin-associated protein), delta 2 0.193394
DAZL deleted in azoospermia-like 0.192746
PICALM phosphatidylinositol binding clathrin assembly protein 0.191777
MYH9 myosin, heavy chain 9, non-muscle 0.190495
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 0.18796
CETN1 centrin, EF-hand protein, 1 0.186708
MYO6 myosin VI 0.186708
ARF5 ADP-ribosylation factor 5 0.185777
PPP6C protein phosphatase 6, catalytic subunit 0.181823
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme 0.181524
AMPH amphiphysin 0.180634
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.180045
PPP5C protein phosphatase 5, catalytic subunit 0.177439
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 0.177154
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.176587
GYPE glycophorin E (MNS blood group) 0.171937
SEPT6 septin 6 0.169859
KIF2A kinesin heavy chain member 2A 0.168101
CDC6 cell division cycle 6 0.166405
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme 0.164542
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 0.163641
HAX1 HCLS1 associated protein X-1 0.159462
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.158315
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.158129
NUF2 NUF2, NDC80 kinetochore complex component 0.158129
MYH10 myosin, heavy chain 10, non-muscle 0.15776
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.157578
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.157218