clathrin complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A protein complex that consists of three clathrin heavy chains and three clathrin light chains, organized into a symmetrical three-legged structure called a triskelion. In clathrin-coated vesicles clathrin is the main component of the coat and forms a polymeric mechanical scaffold on the vesicle surface. (Gene Ontology, GO_0071439)
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Genes

297 proteins co-occuring with the clathrin complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
SNAP91 synaptosomal-associated protein, 91kDa 2.35689
EPS15 epidermal growth factor receptor pathway substrate 15 1.99262
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 1.97062
CLTC clathrin, heavy chain (Hc) 1.77144
TF transferrin 1.7026
HSPA8 heat shock 70kDa protein 8 1.62531
CAV1 caveolin 1, caveolae protein, 22kDa 1.62
HIP1 huntingtin interacting protein 1 1.61706
CLINT1 clathrin interactor 1 1.6106
HIP1R huntingtin interacting protein 1 related 1.57474
PICALM phosphatidylinositol binding clathrin assembly protein 1.56389
EPN1 epsin 1 1.50961
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 1.50114
AP2B1 adaptor-related protein complex 2, beta 1 subunit 1.48927
AMPH amphiphysin 1.48871
AP2M1 adaptor-related protein complex 2, mu 1 subunit 1.47457
ARF6 ADP-ribosylation factor 6 1.47287
ARRB2 arrestin, beta 2 1.45081
ARRB1 arrestin, beta 1 1.43387
AP1M2 adaptor-related protein complex 1, mu 2 subunit 1.42542
EEA1 early endosome antigen 1 1.326
DNM2 dynamin 2 1.32275
TFRC transferrin receptor 1.31196
GAK cyclin G associated kinase 1.29531
SYNJ1 synaptojanin 1 1.18697
CLTB clathrin, light chain B 1.14443
SNX9 sorting nexin 9 1.14034
AAK1 AP2 associated kinase 1 1.12296
DNM1 dynamin 1 1.09136
ARF1 ADP-ribosylation factor 1 1.08272
CLTA clathrin, light chain A 1.05488
M6PR mannose-6-phosphate receptor (cation dependent) 1.04281
ALK anaplastic lymphoma receptor tyrosine kinase 0.990736
CDKN2A cyclin-dependent kinase inhibitor 2A 0.984393
TACC3 transforming, acidic coiled-coil containing protein 3 0.963588
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.945432
SH3GL2 SH3-domain GRB2-like 2 0.938322
SYNRG synergin, gamma 0.937377
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 0.919514
DNAH8 dynein, axonemal, heavy chain 8 0.909716
LDLR low density lipoprotein receptor 0.905996
STON2 stonin 2 0.898109
AFTPH aftiphilin 0.894868
NECAP1 NECAP endocytosis associated 1 0.894868
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.894406
LRP2 low density lipoprotein receptor-related protein 2 0.885628
AP2S1 adaptor-related protein complex 2, sigma 1 subunit 0.885628
FCHO1 FCH domain only 1 0.884705
FLOT1 flotillin 1 0.874107
OCRL oculocerebrorenal syndrome of Lowe 0.852961
ITSN2 intersectin 2 0.835056
BIN1 bridging integrator 1 0.820829
FGF19 fibroblast growth factor 19 0.79652
SCYL2 SCY1-like 2 (S. cerevisiae) 0.790106
LAMP1 lysosomal-associated membrane protein 1 0.788733
TOM1 target of myb1 (chicken) 0.787359
TOM1L1 target of myb1 (chicken)-like 1 0.786902
EGFR epidermal growth factor receptor 0.785529
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.777755
ADRB2 adrenoceptor beta 2, surface 0.776841
IGF2R insulin-like growth factor 2 receptor 0.775471
CTTN cortactin 0.772275
AP2A1 adaptor-related protein complex 2, alpha 1 subunit 0.769539
HSPA4 heat shock 70kDa protein 4 0.715014
EPN3 epsin 3 0.708366
GSTM1 glutathione S-transferase mu 1 0.696905
TNK2 tyrosine kinase, non-receptor, 2 0.695587
HTT huntingtin 0.678978
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 0.678543
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 0.675499
CKAP5 cytoskeleton associated protein 5 0.673762
CDC42 cell division cycle 42 0.664232
TGOLN2 trans-golgi network protein 2 0.659482
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.65388
RABEP1 rabaptin, RAB GTPase binding effector protein 1 0.648291
CCDC83 coiled-coil domain containing 83 0.647433
SMAP2 small ArfGAP2 0.647433
INPP5B inositol polyphosphate-5-phosphatase, 75kDa 0.640573
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.629039
FCHO2 FCH domain only 2 0.626483
BAIAP2L2 BAI1-associated protein 2-like 2 0.623079
LDLRAP1 low density lipoprotein receptor adaptor protein 1 0.617557
PACS1 phosphofurin acidic cluster sorting protein 1 0.615861
CALY calcyon neuron-specific vesicular protein 0.613318
MYO6 myosin VI 0.612895
TSG101 tumor susceptibility 101 0.603174
DNM3 dynamin 3 0.589714
RAB22A RAB22A, member RAS oncogene family 0.589295
GRB2 growth factor receptor-bound protein 2 0.588037
FLOT2 flotillin 2 0.576747
SAR1A secretion associated, Ras related GTPase 1A 0.574662
ARF3 ADP-ribosylation factor 3 0.574244
GPR19 G protein-coupled receptor 19 0.568832
STX6 syntaxin 6 0.567169
SPTLC3 serine palmitoyltransferase, long chain base subunit 3 0.555973
NSF N-ethylmaleimide-sensitive factor 0.554318
BRD8 bromodomain containing 8 0.551838
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.551425
SNX30 sorting nexin family member 30 0.549773
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.549773
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.549773
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.54936
ADRBK1 adrenergic, beta, receptor kinase 1 0.546472
SFTA2 surfactant associated 2 0.543587
EHD1 EH-domain containing 1 0.540706
RAP2B RAP2B, member of RAS oncogene family 0.538649
AP1M1 adaptor-related protein complex 1, mu 1 subunit 0.528798
RAB1B RAB1B, member RAS oncogene family 0.527979
CD63 CD63 molecule 0.527979
BATF2 basic leucine zipper transcription factor, ATF-like 2 0.52716
MIR217 microRNA 217 0.524294
TOM1L2 target of myb1-like 2 (chicken) 0.507977
ARR3 arrestin 3, retinal (X-arrestin) 0.504724
SYT1 synaptotagmin I 0.502693
ZBTB3 zinc finger and BTB domain containing 3 0.495395
CAV2 caveolin 2 0.49418
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma 0.49418
CLTCL1 clathrin, heavy chain-like 1 0.488519
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 0.487711
RNF216 ring finger protein 216 0.486096
EPN2 epsin 2 0.478843
DENND1A DENN/MADD domain containing 1A 0.47844
CMTM7 CKLF-like MARVEL transmembrane domain containing 7 0.475223
DGCR2 DiGeorge syndrome critical region gene 2 0.475223
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.473215
VTI1B vesicle transport through interaction with t-SNAREs 1B 0.472011
CSN1S1 casein alpha s1 0.4672
LAMP2 lysosomal-associated membrane protein 2 0.464397
RFTN1 raftlin, lipid raft linker 1 0.45641
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.449643
SNX21 sorting nexin family member 21 0.437751
PKN1 protein kinase N1 0.434196
TOLLIP toll interacting protein 0.434196
CD209 CD209 molecule 0.433012
SYK spleen tyrosine kinase 0.431829
WASF1 WAS protein family, member 1 0.426711
ANXA2 annexin A2 0.42396
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1 0.421604
LRP6 low density lipoprotein receptor-related protein 6 0.417294
CLVS1 clavesin 1 0.415337
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 0.412601
SORT1 sortilin 1 0.411039
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 0.40247
UBASH3A ubiquitin associated and SH3 domain containing A 0.400527
SYP synaptophysin 0.393549
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.392388
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.392001
INS insulin 0.386208
PRNP prion protein 0.380429
PI4K2A phosphatidylinositol 4-kinase type 2 alpha 0.373516
AP2A2 adaptor-related protein complex 2, alpha 2 subunit 0.372749
AP1S1 adaptor-related protein complex 1, sigma 1 subunit 0.370833
RAB12 RAB12, member RAS oncogene family 0.370067
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.361277
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 0.360515
ALB albumin 0.360515
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.356705
PTAFR platelet-activating factor receptor 0.355944
AQP2 aquaporin 2 (collecting duct) 0.354802
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.352142
PRKCDBP protein kinase C, delta binding protein 0.345314
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) 0.344178
LMBR1 limb development membrane protein 1 0.340773
CTSD cathepsin D 0.339639
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.339639
CYTH3 cytohesin 3 0.339261
DNM1L dynamin 1-like 0.336619
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.331342
RAB11FIP4 RAB11 family interacting protein 4 (class II) 0.326078
ATP11A ATPase, class VI, type 11A 0.323075
ANXA7 annexin A7 0.321575
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 0.320826
ARC activity-regulated cytoskeleton-associated protein 0.320451
EXOC3 exocyst complex component 3 0.319328
CD2AP CD2-associated protein 0.318579
DENND3 DENN/MADD domain containing 3 0.317456
PI3 peptidase inhibitor 3, skin-derived 0.317456
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 0.313718
FIG4 FIG4 phosphoinositide 5-phosphatase 0.310732
TBX1 T-box 1 0.305515
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) 0.305515
TPM3 tropomyosin 3 0.304399
GPR107 G protein-coupled receptor 107 0.303655
SAG S-antigen; retina and pineal gland (arrestin) 0.301425
DMKN dermokine 0.298084
PEAR1 platelet endothelial aggregation receptor 1 0.29623
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.293637
IQSEC1 IQ motif and Sec7 domain 1 0.291047
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.28846
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.287721
PTRF polymerase I and transcript release factor 0.287352
MYLIP myosin regulatory light chain interacting protein 0.287352
CSNK2B casein kinase 2, beta polypeptide 0.286983
DENND1C DENN/MADD domain containing 1C 0.286983
CHRM1 cholinergic receptor, muscarinic 1 0.285138
TBC1D5 TBC1 domain family, member 5 0.284769
EZR ezrin 0.284769
RAB5A RAB5A, member RAS oncogene family 0.282926
PIGR polymeric immunoglobulin receptor 0.281085
HOXA5 homeobox A5 0.280349
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.27998
GPR135 G protein-coupled receptor 135 0.277406
PGRMC1 progesterone receptor membrane component 1 0.275569
SHOC2 soc-2 suppressor of clear homolog (C. elegans) 0.275202
GALR2 galanin receptor 2 0.271533
SNX5 sorting nexin 5 0.271533
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.270434
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 0.269335
STAB2 stabilin 2 0.264581
NPC1L1 NPC1-like 1 0.264215
TJP1 tight junction protein 1 0.264215
PCSK9 proprotein convertase subtilisin/kexin type 9 0.261296
SH3BP4 SH3-domain binding protein 4 0.260931
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.260931
WAS Wiskott-Aldrich syndrome 0.259109
EHD2 EH-domain containing 2 0.258745
PMM1 phosphomannomutase 1 0.256197
SPG11 spastic paraplegia 11 (autosomal recessive) 0.253653
BST2 bone marrow stromal cell antigen 2 0.251114
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.249302
SYS1 Sys1 golgi trafficking protein 0.248216
COPZ2 coatomer protein complex, subunit zeta 2 0.246407
GPR182 G protein-coupled receptor 182 0.244601
RAB34 RAB34, member RAS oncogene family 0.243519
GALR1 galanin receptor 1 0.243158
DENND5A DENN/MADD domain containing 5A 0.242797
MIR214 microRNA 214 0.242076
CXADR coxsackie virus and adenovirus receptor 0.238478
CD59 CD59 molecule, complement regulatory protein 0.235607
AP1S2 adaptor-related protein complex 1, sigma 2 subunit 0.234891
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I 0.230958
PRCC papillary renal cell carcinoma (translocation-associated) 0.228819
AP1B1 adaptor-related protein complex 1, beta 1 subunit 0.223497
CLDN7 claudin 7 0.222083
AP1G2 adaptor-related protein complex 1, gamma 2 subunit 0.221378
USP8 ubiquitin specific peptidase 8 0.217861
CAV3 caveolin 3 0.21681
ZFYVE16 zinc finger, FYVE domain containing 16 0.214714
RAB35 RAB35, member RAS oncogene family 0.214017
EHBP1 EH domain binding protein 1 0.210549
ARF4 ADP-ribosylation factor 4 0.206082
SNX15 sorting nexin 15 0.20574
MAP4 microtubule-associated protein 4 0.205399
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 0.205399
GABARAP GABA(A) receptor-associated protein 0.205399
DCTN4 dynactin 4 (p62) 0.201335
DOT1L DOT1-like histone H3K79 methyltransferase 0.200663
OCLN occludin 0.197662
TFE3 transcription factor binding to IGHM enhancer 3 0.196669
WNT3A wingless-type MMTV integration site family, member 3A 0.19601
SNX18 sorting nexin 18 0.194698
F11R F11 receptor 0.194698
VCL vinculin 0.19307
VAMP4 vesicle-associated membrane protein 4 0.191456
IGF1R insulin-like growth factor 1 receptor 0.189222
CLCN3 chloride channel, voltage-sensitive 3 0.186708
CD4 CD4 molecule 0.184853
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 0.184547
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.184241
KREMEN1 kringle containing transmembrane protein 1 0.183025
TMC6 transmembrane channel-like 6 0.182122
NGF nerve growth factor (beta polypeptide) 0.181823
GLP2R glucagon-like peptide 2 receptor 0.181524
LYN LYN proto-oncogene, Src family tyrosine kinase 0.179752
DNMBP dynamin binding protein 0.179459
INPP5A inositol polyphosphate-5-phosphatase, 40kDa 0.177154
JAKMIP1 janus kinase and microtubule interacting protein 1 0.176587
TFG TRK-fused gene 0.176305
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit 0.174911
OR3A1 olfactory receptor, family 3, subfamily A, member 1 0.171937
MAP2 microtubule-associated protein 2 0.17141
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 0.170888
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 0.170629
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.170371
CRHR2 corticotropin releasing hormone receptor 2 0.170371
STX10 syntaxin 10 0.169604
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.169099
NOTCH1 notch 1 0.168847
MET MET proto-oncogene, receptor tyrosine kinase 0.168598
UBE2J1 ubiquitin-conjugating enzyme E2, J1 0.168101
SNX33 sorting nexin 33 0.167611
ANKRD23 ankyrin repeat domain 23 0.166884
BCR breakpoint cluster region 0.166884
VCP valosin containing protein 0.166884
PLCE1 phospholipase C, epsilon 1 0.165932
ARFIP1 ADP-ribosylation factor interacting protein 1 0.165231
VSNL1 visinin-like 1 0.164542
XYLT2 xylosyltransferase II 0.163865
ANXA6 annexin A6 0.163865
ICAM3 intercellular adhesion molecule 3 0.16342
MAPT microtubule-associated protein tau 0.161905
KIFC2 kinesin family member C2 0.161905
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 0.161275
FURIN furin (paired basic amino acid cleaving enzyme) 0.161068
CLDN1 claudin 1 0.160254
CYSLTR1 cysteinyl leukotriene receptor 1 0.157039
BLOC1S3 biogenesis of lysosomal organelles complex-1, subunit 3 0.156513