cinoxacin-6257 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the cinoxacin-6257 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCY6 adenylate cyclase 6
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
ADTRP androgen-dependent TFPI-regulating protein
ARSB arylsulfatase B
ASIC1 acid sensing (proton gated) ion channel 1
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BAIAP3 BAI1-associated protein 3
BRCA1 breast cancer 1, early onset
CABIN1 calcineurin binding protein 1
CAMK4 calcium/calmodulin-dependent protein kinase IV
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLCN7 chloride channel, voltage-sensitive 7
CLDN10 claudin 10
COL1A1 collagen, type I, alpha 1
COL6A1 collagen, type VI, alpha 1
CRELD1 cysteine-rich with EGF-like domains 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DNAL4 dynein, axonemal, light chain 4
ELK1 ELK1, member of ETS oncogene family
EPHB3 EPH receptor B3
FAM134B family with sequence similarity 134, member B
FAM149B1 family with sequence similarity 149, member B1
FAM189A2 family with sequence similarity 189, member A2
FCAR Fc fragment of IgA receptor
FGFR1 fibroblast growth factor receptor 1
FKBP8 FK506 binding protein 8, 38kDa
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GJA9 gap junction protein, alpha 9, 59kDa
GOSR1 golgi SNAP receptor complex member 1
GRIK5 glutamate receptor, ionotropic, kainate 5
HBS1L HBS1-like translational GTPase
HFE hemochromatosis
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IFITM1 interferon induced transmembrane protein 1
IL6ST interleukin 6 signal transducer
IRF1 interferon regulatory factor 1
IRF5 interferon regulatory factor 5
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
KATNB1 katanin p80 (WD repeat containing) subunit B 1
KREMEN2 kringle containing transmembrane protein 2
LAMP3 lysosomal-associated membrane protein 3
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LMAN1 lectin, mannose-binding, 1
LMBR1L limb development membrane protein 1-like
LPIN2 lipin 2
MANBA mannosidase, beta A, lysosomal
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK13 mitogen-activated protein kinase 13
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MLF1 myeloid leukemia factor 1
NCBP1 nuclear cap binding protein subunit 1, 80kDa
NDRG2 NDRG family member 2
NEUROD4 neuronal differentiation 4
NUMA1 nuclear mitotic apparatus protein 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OASL 2'-5'-oligoadenylate synthetase-like
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLSCR3 phospholipid scramblase 3
POLQ polymerase (DNA directed), theta
PPT2 palmitoyl-protein thioesterase 2
PRR4 proline rich 4 (lacrimal)
RUNX1 runt-related transcription factor 1
SFXN3 sideroflexin 3
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SH2B3 SH2B adaptor protein 3
SHANK2 SH3 and multiple ankyrin repeat domains 2
SIGLEC6 sialic acid binding Ig-like lectin 6
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SMTN smoothelin
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNN stannin
SPPL2B signal peptide peptidase like 2B
STS steroid sulfatase (microsomal), isozyme S
SUGP1 SURP and G patch domain containing 1
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)
TNK2 tyrosine kinase, non-receptor, 2
TOM1 target of myb1 (chicken)
TSPAN9 tetraspanin 9
TTC28 tetratricopeptide repeat domain 28
TWF1 twinfilin actin binding protein 1
USB1 U6 snRNA biogenesis 1
USP19 ubiquitin specific peptidase 19
WAS Wiskott-Aldrich syndrome
WDR25 WD repeat domain 25
WNT6 wingless-type MMTV integration site family, member 6
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZCCHC11 zinc finger, CCHC domain containing 11
ZNF423 zinc finger protein 423
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7
AHCTF1 AT hook containing transcription factor 1
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATF7IP2 activating transcription factor 7 interacting protein 2
C17ORF80 chromosome 17 open reading frame 80
C19ORF40 chromosome 19 open reading frame 40
CAPN5 calpain 5
CCDC15 coiled-coil domain containing 15
CDR2L cerebellar degeneration-related protein 2-like
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CROT carnitine O-octanoyltransferase
CRYZL1 crystallin, zeta (quinone reductase)-like 1
CTSC cathepsin C
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNM1 dynamin 1
DNMBP dynamin binding protein
ECHDC3 enoyl CoA hydratase domain containing 3
ELOVL4 ELOVL fatty acid elongase 4
ERN2 endoplasmic reticulum to nucleus signaling 2
ETAA1 Ewing tumor-associated antigen 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM86C1 family with sequence similarity 86, member C1
FCHSD2 FCH and double SH3 domains 2
FGD6 FYVE, RhoGEF and PH domain containing 6
FLRT3 fibronectin leucine rich transmembrane protein 3
FLT4 fms-related tyrosine kinase 4
FOSL1 FOS-like antigen 1
FYCO1 FYVE and coiled-coil domain containing 1
FZD4 frizzled class receptor 4
GADD45G growth arrest and DNA-damage-inducible, gamma
GDAP1 ganglioside induced differentiation associated protein 1
GID4 GID complex subunit 4
GLB1L2 galactosidase, beta 1-like 2
GLS2 glutaminase 2 (liver, mitochondrial)
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GRAMD4 GRAM domain containing 4
HIST1H2BC histone cluster 1, H2bc
IFT81 intraflagellar transport 81
IL12RB1 interleukin 12 receptor, beta 1
IMPACT impact RWD domain protein
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
INO80D INO80 complex subunit D
KLC2 kinesin light chain 2
KLHL21 kelch-like family member 21
LIN7B lin-7 homolog B (C. elegans)
LYPD1 LY6/PLAUR domain containing 1
LYPLA2P1 lysophospholipase II pseudogene 1
MAPKBP1 mitogen-activated protein kinase binding protein 1
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MUM1 melanoma associated antigen (mutated) 1
MYH9 myosin, heavy chain 9, non-muscle
NAV2 neuron navigator 2
NCS1 neuronal calcium sensor 1
NSD1 nuclear receptor binding SET domain protein 1
PADI1 peptidyl arginine deiminase, type I
PILRB paired immunoglobin-like type 2 receptor beta
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLD3 phospholipase D family, member 3
POMT2 protein-O-mannosyltransferase 2
PRPH peripherin
PSKH1 protein serine kinase H1
QTRT1 queuine tRNA-ribosyltransferase 1
QTRTD1 queuine tRNA-ribosyltransferase domain containing 1
RBM41 RNA binding motif protein 41
RGS19 regulator of G-protein signaling 19
RNF126P1 ring finger protein 126 pseudogene 1
RNF25 ring finger protein 25
SIRT6 sirtuin 6
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC38A10 solute carrier family 38, member 10
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMA4 glucuronidase, beta pseudogene
SNX24 sorting nexin 24
SYCP2 synaptonemal complex protein 2
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast)
TMEM2 transmembrane protein 2
TMOD3 tropomodulin 3 (ubiquitous)
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TRAPPC6A trafficking protein particle complex 6A
TRIP10 thyroid hormone receptor interactor 10
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TSPAN5 tetraspanin 5
TUBGCP5 tubulin, gamma complex associated protein 5
ULBP2 UL16 binding protein 2
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VEGFC vascular endothelial growth factor C
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZNF219 zinc finger protein 219
ZNF318 zinc finger protein 318
ZNF492 zinc finger protein 492
ZNF7 zinc finger protein 7
ZNF747 zinc finger protein 747
ZNF770 zinc finger protein 770