ciclosporin-4586 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the ciclosporin-4586 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGR2 anterior gradient 2
AHNAK AHNAK nucleoprotein
AKAP17A A kinase (PRKA) anchor protein 17A
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPHD1 aspartate beta-hydroxylase domain containing 1
BBS9 Bardet-Biedl syndrome 9
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CCNG2 cyclin G2
CDC6 cell division cycle 6
CDH15 cadherin 15, type 1, M-cadherin (myotubule)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CIB2 calcium and integrin binding family member 2
CREB3L2 cAMP responsive element binding protein 3-like 2
CRELD2 cysteine-rich with EGF-like domains 2
CREM cAMP responsive element modulator
CRISP2 cysteine-rich secretory protein 2
CTBP2 C-terminal binding protein 2
CYB561 cytochrome b561
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCTN1 dynactin 1
DCTN2 dynactin 2 (p50)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FICD FIC domain containing
FKBP14 FK506 binding protein 14, 22 kDa
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GK glycerol kinase
GLRA1 glycine receptor, alpha 1
GLRX glutaredoxin (thioltransferase)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HSPA13 heat shock protein 70kDa family, member 13
HYOU1 hypoxia up-regulated 1
INSIG1 insulin induced gene 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KDM6A lysine (K)-specific demethylase 6A
LDLR low density lipoprotein receptor
LGALS4 lectin, galactoside-binding, soluble, 4
LOC157562 uncharacterized LOC157562
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRIF1 ligand dependent nuclear receptor interacting factor 1
LRRK1 leucine-rich repeat kinase 1
LZTFL1 leucine zipper transcription factor-like 1
MANF mesencephalic astrocyte-derived neurotrophic factor
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MID1IP1 MID1 interacting protein 1
MIR22HG MIR22 host gene
MIS12 MIS12 kinetochore complex component
MTFR1 mitochondrial fission regulator 1
MTMR4 myotubularin related protein 4
MXD4 MAX dimerization protein 4
NUPR1 nuclear protein, transcriptional regulator, 1
PALM paralemmin
PAQR5 progestin and adipoQ receptor family member V
PDE4D phosphodiesterase 4D, cAMP-specific
PDIA4 protein disulfide isomerase family A, member 4
PHGDH phosphoglycerate dehydrogenase
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSPH phosphoserine phosphatase
PTN pleiotrophin
RARA retinoic acid receptor, alpha
RNGTT RNA guanylyltransferase and 5'-phosphatase
RPL13 ribosomal protein L13
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SARM1 sterile alpha and TIR motif containing 1
SCEL sciellin
SDF2L1 stromal cell-derived factor 2-like 1
SEC24D SEC24 family member D
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SLC25A30 solute carrier family 25, member 30
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAP25 synaptosomal-associated protein, 25kDa
SOGA1 suppressor of glucose, autophagy associated 1
SPTBN1 spectrin, beta, non-erythrocytic 1
STC2 stanniocalcin 2
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TMEM50B transmembrane protein 50B
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TTC38 tetratricopeptide repeat domain 38
UBA7 ubiquitin-like modifier activating enzyme 7
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UBXN8 UBX domain protein 8
VAMP4 vesicle-associated membrane protein 4
WIPI1 WD repeat domain, phosphoinositide interacting 1
YIPF4 Yip1 domain family, member 4
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF165 zinc finger protein 165
ZNF268 zinc finger protein 268
ZNF804A zinc finger protein 804A

decreased expression

Symbol Name
AATK apoptosis-associated tyrosine kinase
ACE angiotensin I converting enzyme
ACSL5 acyl-CoA synthetase long-chain family member 5
ALPK1 alpha-kinase 1
ANKH ANKH inorganic pyrophosphate transport regulator
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ARL15 ADP-ribosylation factor-like 15
BCAM basal cell adhesion molecule (Lutheran blood group)
BEX1 brain expressed, X-linked 1
BIRC3 baculoviral IAP repeat containing 3
BNC1 basonuclin 1
BTF3P12 basic transcription factor 3 pseudogene 12
C1ORF105 chromosome 1 open reading frame 105
CCDC85C coiled-coil domain containing 85C
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDADC1 cytidine and dCMP deaminase domain containing 1
CDON cell adhesion associated, oncogene regulated
CENPO centromere protein O
CIDEB cell death-inducing DFFA-like effector b
CLCA1 chloride channel accessory 1
CLSTN3 calsyntenin 3
CTC1 CTS telomere maintenance complex component 1
CUL9 cullin 9
CYTH1 cytohesin 1
DAGLA diacylglycerol lipase, alpha
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DLK2 delta-like 2 homolog (Drosophila)
EDAR ectodysplasin A receptor
ELSPBP1 epididymal sperm binding protein 1
EN2 engrailed homeobox 2
EYA4 EYA transcriptional coactivator and phosphatase 4
FAM184A family with sequence similarity 184, member A
FBXL7 F-box and leucine-rich repeat protein 7
GAL3ST4 galactose-3-O-sulfotransferase 4
GBAP1 glucosidase, beta, acid pseudogene 1
GEMIN8 gem (nuclear organelle) associated protein 8
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPX2 glutathione peroxidase 2
HDAC11 histone deacetylase 11
HIST1H1T histone cluster 1, H1t
HIST1H2AJ histone cluster 1, H2aj
IL12RB1 interleukin 12 receptor, beta 1
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IL7 interleukin 7
INCENP inner centromere protein antigens 135/155kDa
IREB2 iron-responsive element binding protein 2
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITPKA inositol-trisphosphate 3-kinase A
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KDM8 lysine (K)-specific demethylase 8
LRRC61 leucine rich repeat containing 61
MEGF8 multiple EGF-like-domains 8
MYH15 myosin, heavy chain 15
NACA2 nascent polypeptide-associated complex alpha subunit 2
NAG18 NAG18 mRNA
NDP Norrie disease (pseudoglioma)
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PCBP4 poly(rC) binding protein 4
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PHC1 polyhomeotic homolog 1 (Drosophila)
PROS1 protein S (alpha)
PTK7 protein tyrosine kinase 7 (inactive)
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RNF126P1 ring finger protein 126 pseudogene 1
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RPP25 ribonuclease P/MRP 25kDa subunit
SARS2 seryl-tRNA synthetase 2, mitochondrial
SCGB2A2 secretoglobin, family 2A, member 2
SIRT2 sirtuin 2
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SMR3A submaxillary gland androgen regulated protein 3A
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TAOK1 TAO kinase 1
TCTN2 tectonic family member 2
TIAM2 T-cell lymphoma invasion and metastasis 2
TIGD6 tigger transposable element derived 6
TMEM212 transmembrane protein 212
TSC22D4 TSC22 domain family, member 4
TSPAN2 tetraspanin 2
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
VEZT vezatin, adherens junctions transmembrane protein
VGF VGF nerve growth factor inducible
VWA1 von Willebrand factor A domain containing 1
WNT10B wingless-type MMTV integration site family, member 10B
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
YY2 YY2 transcription factor
ZNF214 zinc finger protein 214
ZNF428 zinc finger protein 428
ZNF76 zinc finger protein 76
ZNRD1-AS1 ZNRD1 antisense RNA 1