chronic obstructive pulmonary disease Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:3083
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Genes

286 genes associated with the disease chronic obstructive pulmonary disease in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 2.18869
GSTCD glutathione S-transferase, C-terminal domain containing 2.10422
AGER advanced glycosylation end product-specific receptor 2.06126
THSD4 thrombospondin, type I, domain containing 4 2.04532
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 1.89531
INTS12 integrator complex subunit 12 1.89531
MFAP2 microfibrillar-associated protein 2 1.83778
RARB retinoic acid receptor, beta 1.75993
CDC123 cell division cycle 123 1.70502
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 1.69672
TNS1 tensin 1 1.69467
TMEM254 transmembrane protein 254 1.68078
C10ORF11 chromosome 10 open reading frame 11 1.67004
ADGRG6 adhesion G protein-coupled receptor G6 1.67004
PTCH1 patched 1 1.64426
NUBP2 nucleotide binding protein 2 1.63837
FAM13A family with sequence similarity 13, member A 1.63837
ADAM19 ADAM metallopeptidase domain 19 1.62029
CFDP1 craniofacial development protein 1 1.62029
CCDC38 coiled-coil domain containing 38 1.62029
DNER delta/notch-like EGF repeat containing 1.59609
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.5874
HYKK hydroxylysine kinase 1.57556
ANXA11 annexin A11 1.57556
ZSCAN31 zinc finger and SCAN domain containing 31 1.55738
HLA-C major histocompatibility complex, class I, C 1.55738
SORCS2 sortilin-related VPS10 domain containing receptor 2 1.53058
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 1.52489
TTC41P tetratricopeptide repeat domain 41, pseudogene 1.51167
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 1.50909
MAPK10 mitogen-activated protein kinase 10 1.50225
TLN2 talin 2 1.47346
RAB4B RAB4B, member RAS oncogene family 1.47287
SFTPD surfactant protein D 1.45471
PSORS1C1 psoriasis susceptibility 1 candidate 1 1.4479
ARMC2 armadillo repeat containing 2 1.43537
LRP1 low density lipoprotein receptor-related protein 1 1.42467
SLC39A10 solute carrier family 39 (zinc transporter), member 10 1.40277
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit 1.39759
PRKCH protein kinase C, eta 1.39735
IREB2 iron-responsive element binding protein 2 1.39396
LOC153910 uncharacterized LOC153910 1.39172
MECOM MDS1 and EVI1 complex locus 1.37327
FTO fat mass and obesity associated 1.35834
MMP15 matrix metallopeptidase 15 (membrane-inserted) 1.35834
PPT2 palmitoyl-protein thioesterase 2 1.35014
TUSC3 tumor suppressor candidate 3 1.34719
ASB1 ankyrin repeat and SOCS box containing 1 1.33186
WWOX WW domain containing oxidoreductase 1.32598
DAAM2 dishevelled associated activator of morphogenesis 2 1.32598
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 1.32087
RNF150 ring finger protein 150 1.31635
CASC15 cancer susceptibility candidate 15 (non-protein coding) 1.28906
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 1.28906
ITGA1 integrin, alpha 1 1.28906
MICB MHC class I polypeptide-related sequence B 1.28906
PBX2 pre-B-cell leukemia homeobox 2 1.28574
CDYL chromodomain protein, Y-like 1.26953
CCBL2 cysteine conjugate-beta lyase 2 1.26637
PADI3 peptidyl arginine deiminase, type III 1.25477
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 1.25477
PLCE1 phospholipase C, epsilon 1 1.25477
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 1.25477
MOG myelin oligodendrocyte glycoprotein 1.25477
ASTN2 astrotactin 2 1.24194
FOXO3 forkhead box O3 1.24194
ANXA5 annexin A5 1.24194
NOTCH4 notch 4 1.22859
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 1.21996
LOC284294 uncharacterized LOC284294 1.21996
LY6G6D lymphocyte antigen 6 complex, locus G6D 1.21231
FAM227B family with sequence similarity 227, member B 1.2111
DCDC2 doublecortin domain containing 2 1.21019
SPATA13 spermatogenesis associated 13 1.21019
MIR99AHG mir-99a-let-7c cluster host gene 1.19386
PCDH15 protocadherin-related 15 1.19386
PTPRD protein tyrosine phosphatase, receptor type, D 1.19386
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa 1.19386
SNRPN small nuclear ribonucleoprotein polypeptide N 1.19386
FGF7 fibroblast growth factor 7 1.19171
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 1.18117
CHD7 chromodomain helicase DNA binding protein 7 1.17391
FBXO38 F-box protein 38 1.15681
COL1A2 collagen, type I, alpha 2 1.14463
RORA RAR-related orphan receptor A 1.14463
CREB5 cAMP responsive element binding protein 5 1.14463
CALN1 calneuron 1 1.14463
PLXNA4 plexin A4 1.14463
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 1.13617
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 1.10764
ADARB1 adenosine deaminase, RNA-specific, B1 1.10764
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 1.10764
PGBD1 piggyBac transposable element derived 1 1.10555
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 1.07599
CCDC67 coiled-coil domain containing 67 1.07599
JAKMIP3 Janus kinase and microtubule interacting protein 3 1.07599
TRIM71 tripartite motif containing 71, E3 ubiquitin protein ligase 1.07599
LOC100506354 uncharacterized LOC100506354 1.07452
CNTN5 contactin 5 1.06301
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.05943
RAB5B RAB5B, member RAS oncogene family 1.05109
SEZ6L seizure related 6 homolog (mouse)-like 1.04846
EYA1 EYA transcriptional coactivator and phosphatase 1 1.04846
SRP72 signal recognition particle 72kDa 1.04846
RHBDD1 rhomboid domain containing 1 1.04846
ANK1 ankyrin 1, erythrocytic 1.04846
SNTG1 syntrophin, gamma 1 1.04846
ONECUT1 one cut homeobox 1 1.03626
MAST3 microtubule associated serine/threonine kinase 3 1.03089
ZBTB20 zinc finger and BTB domain containing 20 1.02591
NID2 nidogen 2 (osteonidogen) 1.02476
PDE9A phosphodiesterase 9A 1.02476
TBCK TBC1 domain containing kinase 1.02476
CDH23 cadherin-related 23 1.02476
CTNND2 catenin (cadherin-associated protein), delta 2 1.02476
LRRC9 leucine rich repeat containing 9 1.02385
DDR1 discoidin domain receptor tyrosine kinase 1 1.02362
IL6R interleukin 6 receptor 1.00407
ASXL3 additional sex combs like transcriptional regulator 3 1.00407
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 1.00407
PRKCE protein kinase C, epsilon 1.00407
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 1.00407
SERINC5 serine incorporator 5 0.99494
HYDIN HYDIN, axonemal central pair apparatus protein 0.986376
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 0.986376
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.986376
KAZN kazrin, periplakin interacting protein 0.986376
NTM neurotrimin 0.986376
TRIM27 tripartite motif containing 27 0.985233
WWTR1 WW domain containing transcription regulator 1 0.981879
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa 0.980476
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 0.971169
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.971169
CNTLN centlein, centrosomal protein 0.971169
CSMD1 CUB and Sushi multiple domains 1 0.971169
SEPT9 septin 9 0.971169
KANK1 KN motif and ankyrin repeat domains 1 0.971169
SYT10 synaptotagmin X 0.963873
CDK2 cyclin-dependent kinase 2 0.962375
GSTO2 glutathione S-transferase omega 2 0.961022
MSH5 mutS homolog 5 0.95885
SUOX sulfite oxidase 0.950418
SNRPF small nuclear ribonucleoprotein polypeptide F 0.949336
GSG1L GSG1-like 0.92437
IKZF4 IKAROS family zinc finger 4 (Eos) 0.920453
IRF2 interferon regulatory factor 2 0.916706
TSHZ3 teashirt zinc finger homeobox 3 0.915976
MYT1L myelin transcription factor 1-like 0.909246
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.907791
GNA14 guanine nucleotide binding protein (G protein), alpha 14 0.905653
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 0.896938
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.893803
CLOCK clock circadian regulator 0.885884
MLF1 myeloid leukemia factor 1 0.88094
PML promyelocytic leukemia 0.88034
FBXO25 F-box protein 25 0.88034
PAX3 paired box 3 0.868556
COL16A1 collagen, type XVI, alpha 1 0.868031
ACOXL acyl-CoA oxidase-like 0.866472
FOXP1 forkhead box P1 0.861951
ANKRD22 ankyrin repeat domain 22 0.860493
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 0.858922
MIA2 melanoma inhibitory activity 2 0.853791
GFM1 G elongation factor, mitochondrial 1 0.851323
MTMR3 myotubularin related protein 3 0.850837
GALNT16 polypeptide N-acetylgalactosaminyltransferase 16 0.849872
ZNF503-AS1 ZNF503 antisense RNA 1 0.848917
LXN latexin 0.845646
C5ORF56 chromosome 5 open reading frame 56 0.845646
UST uronyl-2-sulfotransferase 0.840723
LIPF lipase, gastric 0.834806
MYO1D myosin ID 0.831981
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.828571
SCNN1B sodium channel, non voltage gated 1 beta subunit 0.827715
BNC2 basonuclin 2 0.826866
STAMBPL1 STAM binding protein-like 1 0.825607
DLG2 discs, large homolog 2 (Drosophila) 0.824776
MEAF6 MYST/Esa1-associated factor 6 0.819144
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.818364
PLAGL1 pleiomorphic adenoma gene-like 1 0.817591
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa 0.804959
BAALC brain and acute leukemia, cytoplasmic 0.804621
ATP11A ATPase, class VI, type 11A 0.802948
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.802617
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.79917
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa 0.79774
SLC12A8 solute carrier family 12, member 8 0.797032
UTRN utrophin 0.79668
ATXN7L1 ataxin 7-like 1 0.791869
YLPM1 YLP motif containing 1 0.788564
TMOD1 tropomodulin 1 0.787593
ERBB4 erb-b2 receptor tyrosine kinase 4 0.779539
SDC2 syndecan 2 0.778355
IL17RA interleukin 17 receptor A 0.777767
KCNIP4 Kv channel interacting protein 4 0.775739
SIAH3 siah E3 ubiquitin protein ligase family member 3 0.77291
ZNF322 zinc finger protein 322 0.770158
SGCZ sarcoglycan, zeta 0.768778
PREP prolyl endopeptidase 0.766993
REEP1 receptor accessory protein 1 0.765529
RAB3C RAB3C, member RAS oncogene family 0.762941
CYFIP2 cytoplasmic FMR1 interacting protein 2 0.760971
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.760692
LOC285819 uncharacterized LOC285819 0.757946
C6ORF58 chromosome 6 open reading frame 58 0.752142
CLEC19A C-type lectin domain family 19, member A 0.750612
FLJ33534 uncharacterized LOC285150 0.749856
FOCAD focadhesin 0.74567
NR2C1 nuclear receptor subfamily 2, group C, member 1 0.743756
NIPAL4 NIPA-like domain containing 4 0.741413
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 0.736216
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.733819
LOC644145 exocyst complex component 1 pseudogene 0.724637
IL16 interleukin 16 0.724417
ROPN1 rhophilin associated tail protein 1 0.72376
NTNG1 netrin G1 0.722673
CNTN4 contactin 4 0.72117
NANP N-acetylneuraminic acid phosphatase 0.72117
FKBP14 FK506 binding protein 14, 22 kDa 0.71864
HK1 hexokinase 1 0.718224
ARMC1 armadillo repeat containing 1 0.716781
STMN2 stathmin 2 0.716576
GRK5 G protein-coupled receptor kinase 5 0.715965
STK39 serine threonine kinase 39 0.70719
MYO18B myosin XVIIIB 0.705888
AKAP13 A kinase (PRKA) anchor protein 13 0.70333
CLIP3 CAP-GLY domain containing linker protein 3 0.70279
PPFIA2 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 0.701191
OTUD3 OTU deubiquitinase 3 0.70084
RAB38 RAB38, member RAS oncogene family 0.699446
BTN2A1 butyrophilin, subfamily 2, member A1 0.69739
STON2 stonin 2 0.696042
OFCC1 orofacial cleft 1 candidate 1 0.695875
ANO2 anoctamin 2, calcium activated chloride channel 0.694381
VWF von Willebrand factor 0.6921
SHISA9 shisa family member 9 0.69066
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) 0.688927
FOXN3 forkhead box N3 0.687994
PDE1A phosphodiesterase 1A, calmodulin-dependent 0.685698
PQLC3 PQ loop repeat containing 3 0.685698
TRPC7 transient receptor potential cation channel, subfamily C, member 7 0.685245
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 0.684944
PRKCI protein kinase C, iota 0.684345
C2ORF50 chromosome 2 open reading frame 50 0.683009
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 0.680967
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) 0.680967
SYNE2 spectrin repeat containing, nuclear envelope 2 0.680822
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.679533
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 0.679391
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 0.679391
FMNL2 formin-like 2 0.679107
PAX8 paired box 8 0.6784
PLCXD2 phosphatidylinositol-specific phospholipase C, X domain containing 2 0.676035
SLC39A12 solute carrier family 39 (zinc transporter), member 12 0.67576
SUSD4 sushi domain containing 4 0.675487
ADRB2 adrenoceptor beta 2, surface 0.674399
CHL1 cell adhesion molecule L1-like 0.673859
TRPC3 transient receptor potential cation channel, subfamily C, member 3 0.670258
MTNR1B melatonin receptor 1B 0.669747
GNG4 guanine nucleotide binding protein (G protein), gamma 4 0.669341
LMX1A LIM homeobox transcription factor 1, alpha 0.650844
TMTC1 transmembrane and tetratricopeptide repeat containing 1 0.608439
SESN1 sestrin 1 0.594024
SOX5 SRY (sex determining region Y)-box 5 0.591358
SMAD3 SMAD family member 3 0.588801
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 0.586345
FKBP5 FK506 binding protein 5 0.574821
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.570595
AKNAD1 AKNA domain containing 1 0.552035
CCDC149 coiled-coil domain containing 149 0.547225
ANGPT1 angiopoietin 1 0.544152
PADI2 peptidyl arginine deiminase, type II 0.542435
FAM65B family with sequence similarity 65, member B 0.542127
PDE7B phosphodiesterase 7B 0.541061
NWD2 NACHT and WD repeat domain containing 2 0.535269
NUMB numb homolog (Drosophila) 0.533894
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 0.532547
CDH13 cadherin 13 0.52866
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 0.519258
ANG angiogenin, ribonuclease, RNase A family, 5 0.51399
BICD1 bicaudal D homolog 1 (Drosophila) 0.512529
PRSS3 protease, serine, 3 0.502485
ASIC2 acid sensing (proton gated) ion channel 2 0.501829
GRIK2 glutamate receptor, ionotropic, kainate 2 0.498668
WNK2 WNK lysine deficient protein kinase 2 0.498059
TMEM72-AS1 TMEM72 antisense RNA 1 0.474846