chronic obstructive pulmonary disease Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
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Genes

411 genes associated with the disease chronic obstructive pulmonary disease in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACE angiotensin I converting enzyme
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
AHR aryl hydrocarbon receptor
AHRR aryl-hydrocarbon receptor repressor
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase)
AKR1C3 aldo-keto reductase family 1, member C3
AKR1C4 aldo-keto reductase family 1, member C4
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALAD aminolevulinate dehydratase
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX12 arachidonate 12-lipoxygenase
ALOX15 arachidonate 15-lipoxygenase
ALOX5 arachidonate 5-lipoxygenase
AMACR alpha-methylacyl-CoA racemase
AMT aminomethyltransferase
APAF1 apoptotic peptidase activating factor 1
APC adenomatous polyposis coli
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOA2 apolipoprotein A-II
APOA4 apolipoprotein A-IV
APOB apolipoprotein B
APOE apolipoprotein E
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARNT aryl hydrocarbon receptor nuclear translocator
ATM ATM serine/threonine kinase
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide
AURKA aurora kinase A
AXIN2 axin 2
BAK1 BCL2-antagonist/killer 1
BARD1 BRCA1 associated RING domain 1
BAX BCL2-associated X protein
BCL6 B-cell CLL/lymphoma 6
BCR breakpoint cluster region
BHMT betaine--homocysteine S-methyltransferase
BIRC3 baculoviral IAP repeat containing 3
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRIP1 BRCA1 interacting protein C-terminal helicase 1
CALCR calcitonin receptor
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CASR calcium-sensing receptor
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CBR1 carbonyl reductase 1
CBR3 carbonyl reductase 3
CBS cystathionine-beta-synthase
CCL5 chemokine (C-C motif) ligand 5
CCNA2 cyclin A2
CCND1 cyclin D1
CCND3 cyclin D3
CCNH cyclin H
CCR2 chemokine (C-C motif) receptor 2
CCR3 chemokine (C-C motif) receptor 3
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CD4 CD4 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD80 CD80 molecule
CD81 CD81 molecule
CD86 CD86 molecule
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC25C cell division cycle 25C
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK4 cyclin-dependent kinase 4
CDK5 cyclin-dependent kinase 5
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2A cyclin-dependent kinase inhibitor 2A
CETP cholesteryl ester transfer protein, plasma
CFH complement factor H
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CGA glycoprotein hormones, alpha polypeptide
CHEK1 checkpoint kinase 1
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
COL18A1 collagen, type XVIII, alpha 1
COMT catechol-O-methyltransferase
CRP C-reactive protein, pentraxin-related
CSF1R colony stimulating factor 1 receptor
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSF3 colony stimulating factor 3 (granulocyte)
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CTH cystathionine gamma-lyase
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSH cathepsin H
CUL3 cullin 3
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
CYBB cytochrome b-245, beta polypeptide
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DEFB1 defensin, beta 1
DHDH dihydrodiol dehydrogenase (dimeric)
DHFR dihydrofolate reductase
DIO1 deiodinase, iodothyronine, type I
DNAJC18 DnaJ (Hsp40) homolog, subfamily C, member 18
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD4 dopamine receptor D4
EDN1 endothelin 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
ENG endoglin
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPHX2 epoxide hydrolase 2, cytoplasmic
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
ERCC3 excision repair cross-complementation group 3
ERCC4 excision repair cross-complementation group 4
ERCC5 excision repair cross-complementation group 5
ERCC6 excision repair cross-complementation group 6
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
EXO1 exonuclease 1
EZR ezrin
FAM13A family with sequence similarity 13, member A
FANCA Fanconi anemia, complementation group A
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXC1 forkhead box C1
FUT2 fucosyltransferase 2 (secretor status included)
FZD7 frizzled class receptor 7
GATA3 GATA binding protein 3
GC group-specific component (vitamin D binding protein)
GDF15 growth differentiation factor 15
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GHR growth hormone receptor
GPX1 glutathione peroxidase 1
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
GPX4 glutathione peroxidase 4
GSK3B glycogen synthase kinase 3 beta
GSTA4 glutathione S-transferase alpha 4
GSTM1 glutathione S-transferase mu 1
GSTO1 glutathione S-transferase omega 1
GSTO2 glutathione S-transferase omega 2
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
GSTZ1 glutathione S-transferase zeta 1
GYPA glycophorin A (MNS blood group)
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HFE hemochromatosis
HHIP hedgehog interacting protein
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMOX1 heme oxygenase 1
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
HSPB8 heat shock 22kDa protein 8
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HUS1 HUS1 checkpoint homolog (S. pombe)
ICAM1 intercellular adhesion molecule 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
IFNGR1 interferon gamma receptor 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IGF2-AS IGF2 antisense RNA
IGF2R insulin-like growth factor 2 receptor
IGFALS insulin-like growth factor binding protein, acid labile subunit
IGFBP1 insulin-like growth factor binding protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP6 insulin-like growth factor binding protein 6
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL12A interleukin 12A
IL12B interleukin 12B
IL13 interleukin 13
IL15 interleukin 15
IL15RA interleukin 15 receptor, alpha
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL3 interleukin 3
IL4 interleukin 4
IL4R interleukin 4 receptor
IL6R interleukin 6 receptor
IL7R interleukin 7 receptor
INSR insulin receptor
IREB2 iron-responsive element binding protein 2
IRF1 interferon regulatory factor 1
IRF3 interferon regulatory factor 3
IRS1 insulin receptor substrate 1
JAK3 Janus kinase 3
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT23 keratin 23, type I
LCAT lecithin-cholesterol acyltransferase
LDLR low density lipoprotein receptor
LEP leptin
LEPR leptin receptor
LIG1 ligase I, DNA, ATP-dependent
LIG3 ligase III, DNA, ATP-dependent
LIPC lipase, hepatic
LITAF lipopolysaccharide-induced TNF factor
LMO2 LIM domain only 2 (rhombotin-like 1)
LMOD1 leiomodin 1 (smooth muscle)
LPL lipoprotein lipase
LRP5 low density lipoprotein receptor-related protein 5
LRP6 low density lipoprotein receptor-related protein 6
LTA lymphotoxin alpha
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MATR3 matrin 3
MBD2 methyl-CpG binding domain protein 2
MBD4 methyl-CpG binding domain protein 4
MBL2 mannose-binding lectin (protein C) 2, soluble
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEST mesoderm specific transcript
MET MET proto-oncogene, receptor tyrosine kinase
MGMT O-6-methylguanine-DNA methyltransferase
MIR155HG MIR155 host gene
MLH1 mutL homolog 1
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MPDU1 mannose-P-dolichol utilization defect 1
MPO myeloperoxidase
MREG melanoregulin
MSH2 mutS homolog 2
MSH3 mutS homolog 3
MSH6 mutS homolog 6
MSR1 macrophage scavenger receptor 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MX1 MX dynamin-like GTPase 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYNN myoneurin
MYO5A myosin VA (heavy chain 12, myoxin)
NBN nibrin
NCF2 neutrophil cytosolic factor 2
NCOA3 nuclear receptor coactivator 3
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NINJ1 ninjurin 1
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1H4 nuclear receptor subfamily 1, group H, member 4
NUBP1 nucleotide binding protein 1
NUBP2 nucleotide binding protein 2
OCA2 oculocutaneous albinism II
OGG1 8-oxoguanine DNA glycosylase
OPRD1 opioid receptor, delta 1
OPRM1 opioid receptor, mu 1
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PARP1 poly (ADP-ribose) polymerase 1
PARP4 poly (ADP-ribose) polymerase family, member 4
PCNA proliferating cell nuclear antigen
PCTP phosphatidylcholine transfer protein
PECR peroxisomal trans-2-enoyl-CoA reductase
PGR progesterone receptor
PHB prohibitin
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLK1 polo-like kinase 1
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
POLB polymerase (DNA directed), beta
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POT1 protection of telomeres 1
PPARG peroxisome proliferator-activated receptor gamma
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PTEN phosphatase and tensin homolog
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTH parathyroid hormone
RAB15 RAB15, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAD23B RAD23 homolog B (S. cerevisiae)
RAD51 RAD51 recombinase
RAD52 RAD52 homolog (S. cerevisiae)
RAD54L RAD54-like (S. cerevisiae)
RAG1 recombination activating gene 1
RB1CC1 RB1-inducible coiled-coil 1
RERG RAS-like, estrogen-regulated, growth inhibitor
RET ret proto-oncogene
RGS17 regulator of G-protein signaling 17
RGS5 regulator of G-protein signaling 5
RGS6 regulator of G-protein signaling 6
RMDN2 regulator of microtubule dynamics 2
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase
RXRA retinoid X receptor, alpha
RXRB retinoid X receptor, beta
SAT2 spermidine/spermine N1-acetyltransferase family member 2
SCARB1 scavenger receptor class B, member 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEC14L2 SEC14-like 2 (S. cerevisiae)
SEP15 15 kDa selenoprotein
SEPP1 selenoprotein P, plasma, 1
SEPT2 septin 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFTPD surfactant protein D
SHBG sex hormone-binding globulin
SLAMF1 signaling lymphocytic activation molecule family member 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC30A4 solute carrier family 30 (zinc transporter), member 4
SLC39A2 solute carrier family 39 (zinc transporter), member 2
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SOAT2 sterol O-acyltransferase 2
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
SOD3 superoxide dismutase 3, extracellular
SPAG16 sperm associated antigen 16
SRA1 steroid receptor RNA activator 1
SSTR3 somatostatin receptor 3
STAT1 signal transducer and activator of transcription 1, 91kDa
STK11 serine/threonine kinase 11
TEP1 telomerase-associated protein 1
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TERF2 telomeric repeat binding factor 2
TERT telomerase reverse transcriptase
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFRC transferrin receptor
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
TGM1 transglutaminase 1
TIMP2 TIMP metallopeptidase inhibitor 2
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TMEM169 transmembrane protein 169
TNF tumor necrosis factor
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNIP1 TNFAIP3 interacting protein 1
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TP53 tumor protein p53
TP53I3 tumor protein p53 inducible protein 3
TP63 tumor protein p63
TSG101 tumor susceptibility 101
TSPO2 translocator protein 2
TYMS thymidylate synthetase
TYR tyrosinase
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4
VCAM1 vascular cell adhesion molecule 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
WRAP53 WD repeat containing, antisense to TP53
WRN Werner syndrome, RecQ helicase-like
XBP1 X-box binding protein 1
XK X-linked Kx blood group
XPC xeroderma pigmentosum, complementation group C
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
ZFPM1 zinc finger protein, FOG family member 1
ZNF230 zinc finger protein 230
ZNF350 zinc finger protein 350