cholinergic neuron Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description Nerves which synthesize the neurotransmitter acetylcholine in their terminals; they include alpha-motor neurons of the spinal cord, cranial nerves innervating skeletal muscle, preganglionic sympathetic and postganglionic parasympathetic neurons. (BRENDA Tissue and Enzyme Source Ontology, BTO_0004902)
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Genes

176 proteins co-occuring with the tissue cholinergic neuron in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
CHAT choline O-acetyltransferase 4.25483
NGF nerve growth factor (beta polypeptide) 3.03854
ACHE acetylcholinesterase (Yt blood group) 2.79653
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 2.62547
NGFR nerve growth factor receptor 2.24268
BCHE butyrylcholinesterase 1.82606
BDNF brain-derived neurotrophic factor 1.73877
PORCN porcupine homolog (Drosophila) 1.72335
PVALB parvalbumin 1.66207
TAC1 tachykinin, precursor 1 1.64206
TH tyrosine hydroxylase 1.62757
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.60514
LHX8 LIM homeobox 8 1.48176
NTF3 neurotrophin 3 1.47755
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 1.47475
CALB1 calbindin 1, 28kDa 1.43385
SST somatostatin 1.40984
GAL galanin/GMAP prepropeptide 1.40846
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 1.32506
CNTF ciliary neurotrophic factor 1.30658
NPY neuropeptide Y 1.30478
NTF4 neurotrophin 4 1.29894
HCRT hypocretin (orexin) neuropeptide precursor 1.27874
VIP vasoactive intestinal peptide 1.26442
ZCCHC12 zinc finger, CCHC domain containing 12 1.22069
CALB2 calbindin 2 1.18512
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 1.18334
FOS FBJ murine osteosarcoma viral oncogene homolog 1.13412
PEBP1 phosphatidylethanolamine binding protein 1 1.08899
NTS neurotensin 1.05104
APP amyloid beta (A4) precursor protein 1.01725
NPS neuropeptide S 1.00938
GDNF glial cell derived neurotrophic factor 0.963767
TRPC7 transient receptor potential cation channel, subfamily C, member 7 0.960744
SLC10A4 solute carrier family 10, member 4 0.949962
TACR3 tachykinin receptor 3 0.923339
GDF2 growth differentiation factor 2 0.901998
MAPT microtubule-associated protein tau 0.900721
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.888829
NEFH neurofilament, heavy polypeptide 0.871061
SDF4 stromal cell derived factor 4 0.861785
FGF2 fibroblast growth factor 2 (basic) 0.829453
SAMD1 sterile alpha motif domain containing 1 0.812726
SYP synaptophysin 0.797708
DRD2 dopamine receptor D2 0.792293
CALCA calcitonin-related polypeptide alpha 0.783972
UTS2 urotensin 2 0.780232
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.7711
KCNK9 potassium channel, two pore domain subfamily K, member 9 0.765711
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 0.750818
LSAMP limbic system-associated membrane protein 0.745864
CCK cholecystokinin 0.739266
PSEN1 presenilin 1 0.7146
NRTN neurturin 0.714189
LYPLA1 lysophospholipase I 0.713369
GAST gastrin 0.706812
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 0.700671
MNX1 motor neuron and pancreas homeobox 1 0.683919
ACLY ATP citrate lyase 0.682695
MAP2 microtubule-associated protein 2 0.68188
TACR1 tachykinin receptor 1 0.667622
GRP gastrin-releasing peptide 0.665995
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 0.661116
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.646911
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 0.644884
TRH thyrotropin-releasing hormone 0.631931
REST RE1-silencing transcription factor 0.629506
CHRM2 cholinergic receptor, muscarinic 2 0.625465
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 0.625061
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 0.61175
NES nestin 0.588832
GHRH growth hormone releasing hormone 0.568025
CNR1 cannabinoid receptor 1 (brain) 0.567227
NKX2-1 NK2 homeobox 1 0.566428
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.562042
ELAVL3 ELAV like neuron-specific RNA binding protein 3 0.560847
FGF1 fibroblast growth factor 1 (acidic) 0.560847
CINP cyclin-dependent kinase 2 interacting protein 0.558059
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 0.557263
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 0.54217
PRIMA1 proline rich membrane anchor 1 0.540188
PNMT phenylethanolamine N-methyltransferase 0.527534
GRIA4 glutamate receptor, ionotropic, AMPA 4 0.525955
PTPRF protein tyrosine phosphatase, receptor type, F 0.52556
CRH corticotropin releasing hormone 0.520041
GSK3B glycogen synthase kinase 3 beta 0.512957
INSRR insulin receptor-related receptor 0.511778
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 0.500398
BACE1 beta-site APP-cleaving enzyme 1 0.492572
GLB1 galactosidase, beta 1 0.487496
MLN motilin 0.485545
PDYN prodynorphin 0.479702
ADORA1 adenosine A1 receptor 0.474646
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.471539
ADAMTSL1 ADAMTS-like 1 0.461465
TACR2 tachykinin receptor 2 0.461465
DCX doublecortin 0.460305
OPRM1 opioid receptor, mu 1 0.449116
ISL1 ISL LIM homeobox 1 0.445268
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 0.438739
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 0.428018
CHODL chondrolectin 0.425344
GFAP glial fibrillary acidic protein 0.423818
APOE apolipoprotein E 0.416195
ENO2 enolase 2 (gamma, neuronal) 0.408972
GALR1 galanin receptor 1 0.407453
SLC35D3 solute carrier family 35, member D3 0.393442
RCOR1 REST corepressor 1 0.392686
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.392309
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.389666
POMC proopiomelanocortin 0.382131
QPCT glutaminyl-peptide cyclotransferase 0.381003
UCN urocortin 0.378748
GLS glutaminase 0.368998
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like 0.364513
LIF leukemia inhibitory factor 0.361527
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 0.355942
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) 0.355198
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 0.352598
ADAMTSL3 ADAMTS-like 3 0.351485
NEFL neurofilament, light polypeptide 0.351114
IGF1 insulin-like growth factor 1 (somatomedin C) 0.348889
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 0.346298
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.341126
UTS2R urotensin 2 receptor 0.331194
LHX6 LIM homeobox 6 0.328262
GBX1 gastrulation brain homeobox 1 0.32753
GLS2 glutaminase 2 (liver, mitochondrial) 0.318407
PSENEN presenilin enhancer gamma secretase subunit 0.311145
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.308612
GHRL ghrelin/obestatin prepropeptide 0.308251
INS insulin 0.303559
NPAS1 neuronal PAS domain protein 1 0.29996
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.299242
SYN1 synapsin I 0.298524
VCX variable charge, X-linked 0.298165
VCX2 variable charge, X-linked 2 0.293508
NACC1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing 0.291008
FGFR2 fibroblast growth factor receptor 2 0.286026
VCX3B variable charge, X-linked 3B 0.284962
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase 0.284607
TAC3 tachykinin 3 0.282837
CHRM1 cholinergic receptor, muscarinic 1 0.281423
GLUL glutamate-ammonia ligase 0.280717
SRPX2 sushi-repeat containing protein, X-linked 2 0.280364
RAB3A RAB3A, member RAS oncogene family 0.278955
SHH sonic hedgehog 0.277549
VCX3A variable charge, X-linked 3A 0.273696
ESR1 estrogen receptor 1 0.272997
ANKRD23 ankyrin repeat domain 23 0.269174
CNTFR ciliary neurotrophic factor receptor 0.268482
DOCK3 dedicator of cytokinesis 3 0.266757
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.263669
HRH3 histamine receptor H3 0.257572
PENK proenkephalin 0.254902
LGALS4 lectin, galactoside-binding, soluble, 4 0.251606
GRM5 glutamate receptor, metabotropic 5 0.251279
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.250627
CA13 carbonic anhydrase XIII 0.250627
TTC34 tetratricopeptide repeat domain 34 0.247079
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 0.242672
GALR2 galanin receptor 2 0.238706
PITX2 paired-like homeodomain 2 0.23459
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.232317
TPH1 tryptophan hydroxylase 1 0.231206
HRH2 histamine receptor H2 0.231206
CREB1 cAMP responsive element binding protein 1 0.227186
PRTN3 proteinase 3 0.226155
LYNX1 Ly6/neurotoxin 1 0.223662
CASS4 Cas scaffolding protein family member 4 0.223419
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1 0.222699
CHKA choline kinase alpha 0.222224
RELN reelin 0.220378
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 0.220378
ALLC allantoicase 0.218186
GCG glucagon 0.214765