chlorpropamide-6291 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the chlorpropamide-6291 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAN aggrecan
AFF4 AF4/FMR2 family, member 4
ALDOB aldolase B, fructose-bisphosphate
ANGPTL2 angiopoietin-like 2
ANXA10 annexin A10
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARSB arylsulfatase B
ATXN7L1 ataxin 7-like 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BET1L Bet1 golgi vesicular membrane trafficking protein-like
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CALB2 calbindin 2
CALML3 calmodulin-like 3
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC88A coiled-coil domain containing 88A
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDK9 cyclin-dependent kinase 9
CELP carboxyl ester lipase pseudogene
CEP68 centrosomal protein 68kDa
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CYB561 cytochrome b561
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DBR1 debranching RNA lariats 1
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DENND2A DENN/MADD domain containing 2A
DMTN dematin actin binding protein
DOK5 docking protein 5
DSTYK dual serine/threonine and tyrosine protein kinase
DTX2 deltex 2, E3 ubiquitin ligase
ECE1 endothelin converting enzyme 1
EDIL3 EGF-like repeats and discoidin I-like domains 3
ENOX1 ecto-NOX disulfide-thiol exchanger 1
ERAP2 endoplasmic reticulum aminopeptidase 2
FRMD1 FERM domain containing 1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRIK5 glutamate receptor, ionotropic, kainate 5
GTF2I general transcription factor IIi
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOXB5 homeobox B5
HPS1 Hermansky-Pudlak syndrome 1
IGFBP7 insulin-like growth factor binding protein 7
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL1RL1 interleukin 1 receptor-like 1
INO80D INO80 complex subunit D
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLHL23 kelch-like family member 23
KRT6B keratin 6B, type II
KRT8P12 keratin 8 pseudogene 12
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFN2 mitofusin 2
MKL1 megakaryoblastic leukemia (translocation) 1
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MT1M metallothionein 1M
NEBL nebulette
NID1 nidogen 1
NPEPL1 aminopeptidase-like 1
NRP2 neuropilin 2
NT5M 5',3'-nucleotidase, mitochondrial
NUMA1 nuclear mitotic apparatus protein 1
OAZ3 ornithine decarboxylase antizyme 3
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PAPPA2 pappalysin 2
PDLIM7 PDZ and LIM domain 7 (enigma)
PHLDB1 pleckstrin homology-like domain, family B, member 1
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
POM121L2 POM121 transmembrane nucleoporin-like 2
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PQLC2 PQ loop repeat containing 2
PTCRA pre T-cell antigen receptor alpha
PTK6 protein tyrosine kinase 6
PTPRE protein tyrosine phosphatase, receptor type, E
RIF1 replication timing regulatory factor 1
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RYR2 ryanodine receptor 2 (cardiac)
SAFB2 scaffold attachment factor B2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SLN sarcolipin
SNRK SNF related kinase
SOS2 son of sevenless homolog 2 (Drosophila)
SSX3 synovial sarcoma, X breakpoint 3
STAG3 stromal antigen 3
TAOK2 TAO kinase 2
TMEM209 transmembrane protein 209
TMSB15A thymosin beta 15a
TRAF3IP2 TRAF3 interacting protein 2
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
ZBED4 zinc finger, BED-type containing 4
ZFP30 ZFP30 zinc finger protein
ZNF174 zinc finger protein 174
ZNF276 zinc finger protein 276
ZNF37BP zinc finger protein 37B, pseudogene
ZNF573 zinc finger protein 573

decreased expression

Symbol Name
AP1B1 adaptor-related protein complex 1, beta 1 subunit
ASB13 ankyrin repeat and SOCS box containing 13
ASB7 ankyrin repeat and SOCS box containing 7
ATF7IP2 activating transcription factor 7 interacting protein 2
BATF3 basic leucine zipper transcription factor, ATF-like 3
BCKDK branched chain ketoacid dehydrogenase kinase
BTF3P12 basic transcription factor 3 pseudogene 12
C1RL complement component 1, r subcomponent-like
C9ORF116 chromosome 9 open reading frame 116
CBX7 chromobox homolog 7
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCDC68 coiled-coil domain containing 68
CCDC85C coiled-coil domain containing 85C
CCNL2 cyclin L2
CDH3 cadherin 3, type 1, P-cadherin (placental)
CNTNAP3B contactin associated protein-like 3B
CTSD cathepsin D
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DENND4A DENN/MADD domain containing 4A
DOLPP1 dolichyldiphosphatase 1
EDEM2 ER degradation enhancer, mannosidase alpha-like 2
EHD3 EH-domain containing 3
ERMP1 endoplasmic reticulum metallopeptidase 1
EVPL envoplakin
FCHSD2 FCH and double SH3 domains 2
FGGY FGGY carbohydrate kinase domain containing
FSD1 fibronectin type III and SPRY domain containing 1
GNL1 guanine nucleotide binding protein-like 1
GPR176 G protein-coupled receptor 176
GRAMD4 GRAM domain containing 4
HIST1H3B histone cluster 1, H3b
HIST1H3G histone cluster 1, H3g
INCENP inner centromere protein antigens 135/155kDa
IP6K1 inositol hexakisphosphate kinase 1
IRF9 interferon regulatory factor 9
KDM5C lysine (K)-specific demethylase 5C
KRI1 KRI1 homolog (S. cerevisiae)
L2HGDH L-2-hydroxyglutarate dehydrogenase
MED15 mediator complex subunit 15
MGMT O-6-methylguanine-DNA methyltransferase
MICALL2 MICAL-like 2
MUC3B mucin 3B, cell surface associated
NBAS neuroblastoma amplified sequence
NLGN1 neuroligin 1
NLRX1 NLR family member X1
NPM3 nucleophosmin/nucleoplasmin 3
NXPH4 neurexophilin 4
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
ORAI3 ORAI calcium release-activated calcium modulator 3
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PDGFD platelet derived growth factor D
PER3 period circadian clock 3
PIEZO1 piezo-type mechanosensitive ion channel component 1
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PILRB paired immunoglobin-like type 2 receptor beta
PLS1 plastin 1
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1
PRPH peripherin
PRR3 proline rich 3
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
PTPN9 protein tyrosine phosphatase, non-receptor type 9
RAB33B RAB33B, member RAS oncogene family
RARS arginyl-tRNA synthetase
RHOBTB1 Rho-related BTB domain containing 1
RP2 retinitis pigmentosa 2 (X-linked recessive)
SCAP SREBF chaperone
SCN1B sodium channel, voltage gated, type I beta subunit
SH2D2A SH2 domain containing 2A
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMAD7 SMAD family member 7
SNIP1 Smad nuclear interacting protein 1
SNX24 sorting nexin 24
SOBP sine oculis binding protein homolog (Drosophila)
STBD1 starch binding domain 1
STIM1 stromal interaction molecule 1
STX1A syntaxin 1A (brain)
TAGLN3 transgelin 3
TMEM132A transmembrane protein 132A
TMEM38B transmembrane protein 38B
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TPK1 thiamin pyrophosphokinase 1
TPST1 tyrosylprotein sulfotransferase 1
TRIM68 tripartite motif containing 68
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TTC23 tetratricopeptide repeat domain 23
TTC31 tetratricopeptide repeat domain 31
TUBG2 tubulin, gamma 2
UVRAG UV radiation resistance associated
VEGFB vascular endothelial growth factor B
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae)
WDR44 WD repeat domain 44
ZBTB48 zinc finger and BTB domain containing 48
ZNF324 zinc finger protein 324
ZNF358 zinc finger protein 358
ZNF442 zinc finger protein 442
ZNF629 zinc finger protein 629