chlorcyclizine-4546 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the chlorcyclizine-4546 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AHNAK AHNAK nucleoprotein
AMH anti-Mullerian hormone
ANGPT4 angiopoietin 4
ARNT aryl hydrocarbon receptor nuclear translocator
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
ATXN2L ataxin 2-like
BCAM basal cell adhesion molecule (Lutheran blood group)
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C14ORF79 chromosome 14 open reading frame 79
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CCDC40 coiled-coil domain containing 40
CD160 CD160 molecule
CD80 CD80 molecule
CD8B CD8b molecule
CDH15 cadherin 15, type 1, M-cadherin (myotubule)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEP295 centrosomal protein 295kDa
CHRNG cholinergic receptor, nicotinic, gamma (muscle)
CLCN6 chloride channel, voltage-sensitive 6
CLN3 ceroid-lipofuscinosis, neuronal 3
CPN2 carboxypeptidase N, polypeptide 2
CSHL1 chorionic somatomammotropin hormone-like 1
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
DOCK6 dedicator of cytokinesis 6
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ERAP1 endoplasmic reticulum aminopeptidase 1
ERO1LB ERO1-like beta (S. cerevisiae)
ETV1 ets variant 1
ETV2 ets variant 2
FAM76A family with sequence similarity 76, member A
FUBP1 far upstream element (FUSE) binding protein 1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAB1 GRB2-associated binding protein 1
GGT1 gamma-glutamyltransferase 1
GMPR guanosine monophosphate reductase
HAP1 huntingtin-associated protein 1
HDAC11 histone deacetylase 11
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IQCK IQ motif containing K
KALRN kalirin, RhoGEF kinase
KANK1 KN motif and ankyrin repeat domains 1
KIAA0125 KIAA0125
KLF13 Kruppel-like factor 13
KRT9 keratin 9, type I
KRTAP5-9 keratin associated protein 5-9
LIFR leukemia inhibitory factor receptor alpha
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MKL1 megakaryoblastic leukemia (translocation) 1
MLANA melan-A
MMP24 matrix metallopeptidase 24 (membrane-inserted)
MORN1 MORN repeat containing 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MVB12B multivesicular body subunit 12B
MYOZ3 myozenin 3
NEK3 NIMA-related kinase 3
NR1H4 nuclear receptor subfamily 1, group H, member 4
NRG2 neuregulin 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDE4C phosphodiesterase 4C, cAMP-specific
PILRA paired immunoglobin-like type 2 receptor alpha
PKNOX2 PBX/knotted 1 homeobox 2
POU6F1 POU class 6 homeobox 1
PTGDR2 prostaglandin D2 receptor 2
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RABGAP1L RAB GTPase activating protein 1-like
RAD51 RAD51 recombinase
RAD51B RAD51 paralog B
RET ret proto-oncogene
RIN3 Ras and Rab interactor 3
RRAGD Ras-related GTP binding D
RUNX1 runt-related transcription factor 1
SAMD4A sterile alpha motif domain containing 4A
SARM1 sterile alpha and TIR motif containing 1
SFTPB surfactant protein B
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SH2D3A SH2 domain containing 3A
SLC48A1 solute carrier family 48 (heme transporter), member 1
SOCS3 suppressor of cytokine signaling 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFB1 transforming growth factor, beta 1
TOP3B topoisomerase (DNA) III beta
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VCAN versican
VGF VGF nerve growth factor inducible
VTN vitronectin
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
ZC3H7B zinc finger CCCH-type containing 7B
ZCCHC11 zinc finger, CCHC domain containing 11
ZNF215 zinc finger protein 215
ZNF224 zinc finger protein 224
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ADCY6 adenylate cyclase 6
APOLD1 apolipoprotein L domain containing 1
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARMCX2 armadillo repeat containing, X-linked 2
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
ATP13A2 ATPase type 13A2
ATXN2 ataxin 2
BIK BCL2-interacting killer (apoptosis-inducing)
BTF3P12 basic transcription factor 3 pseudogene 12
C17ORF70 chromosome 17 open reading frame 70
C19ORF40 chromosome 19 open reading frame 40
CAPN15 calpain 15
CHMP6 charged multivesicular body protein 6
CHST10 carbohydrate sulfotransferase 10
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CNTNAP3B contactin associated protein-like 3B
COG7 component of oligomeric golgi complex 7
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DBR1 debranching RNA lariats 1
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DENND2D DENN/MADD domain containing 2D
ERF Ets2 repressor factor
EVPL envoplakin
EXO1 exonuclease 1
FAM120C family with sequence similarity 120C
FOXN2 forkhead box N2
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GMIP GEM interacting protein
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BO histone cluster 1, H2bo
HIST1H3C histone cluster 1, H3c
HIST1H4D histone cluster 1, H4d
HOXA6 homeobox A6
IPO13 importin 13
IRF2BP1 interferon regulatory factor 2 binding protein 1
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIAA0556 KIAA0556
LIN7B lin-7 homolog B (C. elegans)
LMCD1 LIM and cysteine-rich domains 1
LPPR4 lipid phosphate phosphatase-related protein type 4
LRRC6 leucine rich repeat containing 6
LUC7L LUC7-like (S. cerevisiae)
LZTR1 leucine-zipper-like transcription regulator 1
MAPK12 mitogen-activated protein kinase 12
MAPK3 mitogen-activated protein kinase 3
MBL1P mannose-binding lectin (protein A) 1, pseudogene
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MX1 MX dynamin-like GTPase 1
MYLK myosin light chain kinase
NACA2 nascent polypeptide-associated complex alpha subunit 2
NDP Norrie disease (pseudoglioma)
NOL6 nucleolar protein 6 (RNA-associated)
NOTCH1 notch 1
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
PAIP2B poly(A) binding protein interacting protein 2B
PHLDA3 pleckstrin homology-like domain, family A, member 3
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PRB3 proline-rich protein BstNI subfamily 3
PRSS53 protease, serine, 53
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRS protein tyrosine phosphatase, receptor type, S
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOBTB2 Rho-related BTB domain containing 2
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
SCG5 secretogranin V
SDC3 syndecan 3
SH3GL2 SH3-domain GRB2-like 2
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SIRT6 sirtuin 6
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLITRK5 SLIT and NTRK-like family, member 5
SMR3A submaxillary gland androgen regulated protein 3A
SPRYD7 SPRY domain containing 7
STAG3 stromal antigen 3
STARD3 StAR-related lipid transfer (START) domain containing 3
STRN4 striatin, calmodulin binding protein 4
TGFB3 transforming growth factor, beta 3
TMEM132A transmembrane protein 132A
TNS2 tensin 2
TRIM25 tripartite motif containing 25
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TUBA3C tubulin, alpha 3c
UGT8 UDP glycosyltransferase 8
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
ZNF10 zinc finger protein 10
ZNF177 zinc finger protein 177
ZNF197 zinc finger protein 197
ZNF428 zinc finger protein 428
ZNF747 zinc finger protein 747