cefalexin-5615 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the cefalexin-5615 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADARB1 adenosine deaminase, RNA-specific, B1
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ANGPT4 angiopoietin 4
ANO1 anoctamin 1, calcium activated chloride channel
APOH apolipoprotein H (beta-2-glycoprotein I)
ARSD arylsulfatase D
ASIC4 acid sensing (proton gated) ion channel family member 4
ATXN3 ataxin 3
BLZF1 basic leucine zipper nuclear factor 1
C9ORF156 chromosome 9 open reading frame 156
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCL17 chemokine (C-C motif) ligand 17
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CNTNAP2 contactin associated protein-like 2
CUL7 cullin 7
CYLD cylindromatosis (turban tumor syndrome)
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAO D-amino-acid oxidase
DFNB31 deafness, autosomal recessive 31
EFCAB6 EF-hand calcium binding domain 6
EFNB3 ephrin-B3
EGFL7 EGF-like-domain, multiple 7
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1
F13A1 coagulation factor XIII, A1 polypeptide
FBLN1 fibulin 1
FBN1 fibrillin 1
FBXO40 F-box protein 40
FRMD4B FERM domain containing 4B
FRZB frizzled-related protein
FYB FYN binding protein
FZD9 frizzled class receptor 9
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAS7 growth arrest-specific 7
GGTLC1 gamma-glutamyltransferase light chain 1
GLS glutaminase
GPR161 G protein-coupled receptor 161
HAS1 hyaluronan synthase 1
HDAC6 histone deacetylase 6
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIC2 hypermethylated in cancer 2
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
ICOS inducible T-cell co-stimulator
IGFBP5 insulin-like growth factor binding protein 5
IGLJ3 immunoglobulin lambda joining 3
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IRS2 insulin receptor substrate 2
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KHK ketohexokinase (fructokinase)
KIAA1109 KIAA1109
KLHL22 kelch-like family member 22
KRT17 keratin 17, type I
LAMB4 laminin, beta 4
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LUZP4 leucine zipper protein 4
MAOA monoamine oxidase A
MAPK8 mitogen-activated protein kinase 8
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MIP major intrinsic protein of lens fiber
NEU2 sialidase 2 (cytosolic sialidase)
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NR6A1 nuclear receptor subfamily 6, group A, member 1
OMG oligodendrocyte myelin glycoprotein
OR2H2 olfactory receptor, family 2, subfamily H, member 2
PCSK6 proprotein convertase subtilisin/kexin type 6
PDE12 phosphodiesterase 12
PDIA2 protein disulfide isomerase family A, member 2
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PHLDB1 pleckstrin homology-like domain, family B, member 1
PLCL2 phospholipase C-like 2
PRUNE2 prune homolog 2 (Drosophila)
PYY peptide YY
RAB3B RAB3B, member RAS oncogene family
REEP2 receptor accessory protein 2
RNF126P1 ring finger protein 126 pseudogene 1
RTCA RNA 3'-terminal phosphate cyclase
SARM1 sterile alpha and TIR motif containing 1
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SFRP4 secreted frizzled-related protein 4
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SPN sialophorin
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPPL2B signal peptide peptidase like 2B
SRGN serglycin
SRSF5 serine/arginine-rich splicing factor 5
SSX1 synovial sarcoma, X breakpoint 1
STK11 serine/threonine kinase 11
TBR1 T-box, brain, 1
TBX2 T-box 2
TMEM63A transmembrane protein 63A
TTPA tocopherol (alpha) transfer protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6

decreased expression

Symbol Name
ACSF2 acyl-CoA synthetase family member 2
ADA adenosine deaminase
ADAP2 ArfGAP with dual PH domains 2
ADTRP androgen-dependent TFPI-regulating protein
AFF4 AF4/FMR2 family, member 4
ALAS1 5'-aminolevulinate synthase 1
ALPK1 alpha-kinase 1
AMT aminomethyltransferase
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
BTF3P11 basic transcription factor 3 pseudogene 11
C14ORF79 chromosome 14 open reading frame 79
C1ORF35 chromosome 1 open reading frame 35
CCDC134 coiled-coil domain containing 134
CES3 carboxylesterase 3
CFD complement factor D (adipsin)
CLCF1 cardiotrophin-like cytokine factor 1
CLEC4E C-type lectin domain family 4, member E
CLSTN2 calsyntenin 2
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CNR2 cannabinoid receptor 2 (macrophage)
DOCK4 dedicator of cytokinesis 4
DSCAM Down syndrome cell adhesion molecule
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM131A family with sequence similarity 131, member A
FAM188A family with sequence similarity 188, member A
FBXL6 F-box and leucine-rich repeat protein 6
FCHSD2 FCH and double SH3 domains 2
FER fer (fps/fes related) tyrosine kinase
FRMD1 FERM domain containing 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GFI1 growth factor independent 1 transcription repressor
GID4 GID complex subunit 4
GLI3 GLI family zinc finger 3
GLS2 glutaminase 2 (liver, mitochondrial)
H2AFJ H2A histone family, member J
HIST1H2AI histone cluster 1, H2ai
HIST1H2BJ histone cluster 1, H2bj
HPN hepsin
INO80D INO80 complex subunit D
INPP1 inositol polyphosphate-1-phosphatase
ITFG2 integrin alpha FG-GAP repeat containing 2
KREMEN2 kringle containing transmembrane protein 2
LGMN legumain
LRRC37A3 leucine rich repeat containing 37, member A3
LRRC61 leucine rich repeat containing 61
MAST3 microtubule associated serine/threonine kinase 3
MGC12488
MYO1E myosin IE
NEK11 NIMA-related kinase 11
NME5 NME/NM23 family member 5
NPIPB15 nuclear pore complex interacting protein family, member B15
NPTX1 neuronal pentraxin I
NR1H2 nuclear receptor subfamily 1, group H, member 2
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13
PARP12 poly (ADP-ribose) polymerase family, member 12
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PLEKHO2 pleckstrin homology domain containing, family O member 2
PRICKLE3 prickle homolog 3 (Drosophila)
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
REPS2 RALBP1 associated Eps domain containing 2
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RPL10L ribosomal protein L10-like
RPL23AP32 ribosomal protein L23a pseudogene 32
RRAGB Ras-related GTP binding B
SCN1B sodium channel, voltage gated, type I beta subunit
SGCE sarcoglycan, epsilon
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SMIM14 small integral membrane protein 14
STAG3L1 stromal antigen 3-like 1 (pseudogene)
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SYBU syntabulin (syntaxin-interacting)
TAOK1 TAO kinase 1
TBC1D19 TBC1 domain family, member 19
TBX19 T-box 19
TFF2 trefoil factor 2
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM45A transmembrane protein 45A
TMEM53 transmembrane protein 53
TMEM62 transmembrane protein 62
TMPRSS3 transmembrane protease, serine 3
TOLLIP toll interacting protein
TRAF2 TNF receptor-associated factor 2
TRAIP TRAF interacting protein
TTBK2 tau tubulin kinase 2
UPK3B uroplakin 3B
WDR4 WD repeat domain 4
ZBTB44 zinc finger and BTB domain containing 44
ZNF286A zinc finger protein 286A
ZNF446 zinc finger protein 446
ZNF484 zinc finger protein 484
ZNF573 zinc finger protein 573
ZNF606 zinc finger protein 606
ZNF665 zinc finger protein 665