cefalexin-2628 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the cefalexin-2628 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ALCAM activated leukocyte cell adhesion molecule
AMACR alpha-methylacyl-CoA racemase
ARHGAP35 Rho GTPase activating protein 35
ARR3 arrestin 3, retinal (X-arrestin)
ATF6B activating transcription factor 6 beta
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
ATXN2L ataxin 2-like
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BET1L Bet1 golgi vesicular membrane trafficking protein-like
BMP1 bone morphogenetic protein 1
C10ORF95 chromosome 10 open reading frame 95
C22ORF31 chromosome 22 open reading frame 31
C2ORF68 chromosome 2 open reading frame 68
C3 complement component 3
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CCDC71 coiled-coil domain containing 71
CCKBR cholecystokinin B receptor
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)
CD58 CD58 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
COL19A1 collagen, type XIX, alpha 1
CYTH1 cytohesin 1
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
ERCC6 excision repair cross-complementation group 6
EXTL3 exostosin-like glycosyltransferase 3
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FKBP1B FK506 binding protein 1B, 12.6 kDa
FRK fyn-related Src family tyrosine kinase
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GLRA1 glycine receptor, alpha 1
GM2A GM2 ganglioside activator
GYPB glycophorin B (MNS blood group)
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HIST1H3F histone cluster 1, H3f
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HOXC8 homeobox C8
ICAM1 intercellular adhesion molecule 1
IKZF4 IKAROS family zinc finger 4 (Eos)
IRS2 insulin receptor substrate 2
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB4 integrin, beta 4
JUN jun proto-oncogene
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2
KCTD17 potassium channel tetramerization domain containing 17
KIAA0319L KIAA0319-like
KSR1 kinase suppressor of ras 1
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYF5 myogenic factor 5
MYL10 myosin, light chain 10, regulatory
MYOF myoferlin
NCOA2 nuclear receptor coactivator 2
NDN necdin, melanoma antigen (MAGE) family member
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
NEURL1 neuralized E3 ubiquitin protein ligase 1
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NIN ninein (GSK3B interacting protein)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRXN3 neurexin 3
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OLFML2B olfactomedin-like 2B
ORAI2 ORAI calcium release-activated calcium modulator 2
PCM1 pericentriolar material 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PDAP1 PDGFA associated protein 1
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PLP1 proteolipid protein 1
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RASL11B RAS-like, family 11, member B
RBMS2 RNA binding motif, single stranded interacting protein 2
RPS28 ribosomal protein S28
SAP30 Sin3A-associated protein, 30kDa
SEC24D SEC24 family member D
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SMAD3 SMAD family member 3
SP1 Sp1 transcription factor
SPTAN1 spectrin, alpha, non-erythrocytic 1
ST5 suppression of tumorigenicity 5
STAT2 signal transducer and activator of transcription 2, 113kDa
STX2 syntaxin 2
SUGP1 SURP and G patch domain containing 1
SULT4A1 sulfotransferase family 4A, member 1
SYNGR1 synaptogyrin 1
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
THBD thrombomodulin
TLK1 tousled-like kinase 1
TMPRSS15 transmembrane protease, serine 15
UPK3B uroplakin 3B
USP34 ubiquitin specific peptidase 34
VAV2 vav 2 guanine nucleotide exchange factor
WSCD1 WSC domain containing 1
ZNF154 zinc finger protein 154
ZNF3 zinc finger protein 3
ZNF639 zinc finger protein 639
ZNF696 zinc finger protein 696

decreased expression

Symbol Name
ACSF2 acyl-CoA synthetase family member 2
ADAM15 ADAM metallopeptidase domain 15
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANKRD10 ankyrin repeat domain 10
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATP7A ATPase, Cu++ transporting, alpha polypeptide
BCAS1 breast carcinoma amplified sequence 1
BIRC7 baculoviral IAP repeat containing 7
BMP4 bone morphogenetic protein 4
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BTF3P12 basic transcription factor 3 pseudogene 12
C21ORF91 chromosome 21 open reading frame 91
C5AR2 complement component 5a receptor 2
CCP110 centriolar coiled coil protein 110kDa
CDK3 cyclin-dependent kinase 3
CFAP44 cilia and flagella associated protein 44
CGREF1 cell growth regulator with EF-hand domain 1
CHMP7 charged multivesicular body protein 7
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CLCN2 chloride channel, voltage-sensitive 2
CLSPN claspin
CPPED1 calcineurin-like phosphoesterase domain containing 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DAGLA diacylglycerol lipase, alpha
DDIT3 DNA-damage-inducible transcript 3
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DUSP13 dual specificity phosphatase 13
EFNA3 ephrin-A3
EFTUD1 elongation factor Tu GTP binding domain containing 1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EIF5A2 eukaryotic translation initiation factor 5A2
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ERN2 endoplasmic reticulum to nucleus signaling 2
EXOC5 exocyst complex component 5
EXTL2 exostosin-like glycosyltransferase 2
F3 coagulation factor III (thromboplastin, tissue factor)
FAM189A2 family with sequence similarity 189, member A2
FER fer (fps/fes related) tyrosine kinase
FKBP10 FK506 binding protein 10, 65 kDa
GAMT guanidinoacetate N-methyltransferase
GLS2 glutaminase 2 (liver, mitochondrial)
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GRPR gastrin-releasing peptide receptor
IDI2-AS1 IDI2 antisense RNA 1
JMJD4 jumonji domain containing 4
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KREMEN2 kringle containing transmembrane protein 2
LIG4 ligase IV, DNA, ATP-dependent
LIN7A lin-7 homolog A (C. elegans)
LRP5L low density lipoprotein receptor-related protein 5-like
LY6G6C lymphocyte antigen 6 complex, locus G6C
LZTFL1 leucine zipper transcription factor-like 1
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MED9 mediator complex subunit 9
METTL16 methyltransferase like 16
METTL2B methyltransferase like 2B
MFSD11 major facilitator superfamily domain containing 11
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
NPFFR1 neuropeptide FF receptor 1
NPM3 nucleophosmin/nucleoplasmin 3
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PARPBP PARP1 binding protein
PHC1 polyhomeotic homolog 1 (Drosophila)
RFTN1 raftlin, lipid raft linker 1
RNF146 ring finger protein 146
S100A4 S100 calcium binding protein A4
SCD5 stearoyl-CoA desaturase 5
SCYL2 SCY1-like 2 (S. cerevisiae)
SETD8 SET domain containing (lysine methyltransferase) 8
SIRT6 sirtuin 6
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNAI2 snail family zinc finger 2
SOWAHC sosondowah ankyrin repeat domain family member C
SPINK4 serine peptidase inhibitor, Kazal type 4
SPINK5 serine peptidase inhibitor, Kazal type 5
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TAGLN transgelin
TDRD1 tudor domain containing 1
TGIF1 TGFB-induced factor homeobox 1
TRAF2 TNF receptor-associated factor 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAPPC2 trafficking protein particle complex 2
USP36 ubiquitin specific peptidase 36
WDR13 WD repeat domain 13
WDR4 WD repeat domain 4
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF254 zinc finger protein 254
ZNF446 zinc finger protein 446
ZNF573 zinc finger protein 573