catalytic step 2 spliceosome Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. (Gene Ontology, GO_0071013)
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83 proteins localized to the catalytic step 2 spliceosome cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35 0.663342
SLU7 SLU7 splicing factor homolog (S. cerevisiae) 0.663342
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.663342
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 0.663342
PPIL1 peptidylprolyl isomerase (cyclophilin)-like 1 0.663342
DGCR14 DiGeorge syndrome critical region gene 14 0.663342
WDR83 WD repeat domain 83 0.663342
ZCCHC8 zinc finger, CCHC domain containing 8 0.663342
FRG1 FSHD region gene 1 0.663342
SNRPA1 small nuclear ribonucleoprotein polypeptide A' 0.663342
SART1 squamous cell carcinoma antigen recognized by T cells 0.663342
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 0.663342
CWC15 CWC15 spliceosome-associated protein 0.663342
EFTUD2 elongation factor Tu GTP binding domain containing 2 0.663342
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 0.663342
RBMX RNA binding motif protein, X-linked 0.663342
ALYREF Aly/REF export factor 0.663342
AQR aquarius intron-binding spliceosomal factor 0.663342
CDC40 cell division cycle 40 0.663342
SRSF1 serine/arginine-rich splicing factor 1 0.663342
SF3B3 splicing factor 3b, subunit 3, 130kDa 0.663342
SNRPN small nuclear ribonucleoprotein polypeptide N 0.663342
SF3A2 splicing factor 3a, subunit 2, 66kDa 0.663342
SF3A3 splicing factor 3a, subunit 3, 60kDa 0.663342
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.663342
PABPC1 poly(A) binding protein, cytoplasmic 1 0.663342
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.663342
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.663342
CWC27 CWC27 spliceosome-associated protein homolog (S. cerevisiae) 0.663342
CWC22 CWC22 spliceosome-associated protein 0.663342
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.663342
GPATCH1 G patch domain containing 1 0.663342
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 0.663342
SNRPF small nuclear ribonucleoprotein polypeptide F 0.663342
SNRPG small nuclear ribonucleoprotein polypeptide G 0.663342
SNRPE small nuclear ribonucleoprotein polypeptide E 0.663342
U2AF1 U2 small nuclear RNA auxiliary factor 1 0.663342
RAB43 RAB43, member RAS oncogene family 0.663342
EIF4A3 eukaryotic translation initiation factor 4A3 0.663342
PPIL3 peptidylprolyl isomerase (cyclophilin)-like 3 0.663342
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.663342
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38 0.663342
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.663342
SNW1 SNW domain containing 1 0.663342
MAGOH mago-nashi homolog, proliferation-associated (Drosophila) 0.663342
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.663342
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.663342
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.663342
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.663342
HNRNPF heterogeneous nuclear ribonucleoprotein F 0.663342
ISY1 ISY1 splicing factor homolog (S. cerevisiae) 0.663342
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.663342
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.663342
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa 0.663342
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 0.663342
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa 0.663342
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.663342
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.663342
CRNKL1 crooked neck pre-mRNA splicing factor 1 0.663342
PPIE peptidylprolyl isomerase E (cyclophilin E) 0.663342
RBM22 RNA binding motif protein 22 0.663342
XAB2 XPA binding protein 2 0.663342
SYF2 SYF2 pre-mRNA-splicing factor 0.663342
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae) 0.663342
PRPF8 pre-mRNA processing factor 8 0.663342
PRPF6 pre-mRNA processing factor 6 0.663342
TFIP11 tuftelin interacting protein 11 0.663342
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.663342
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) 0.663342
RALY RALY heterogeneous nuclear ribonucleoprotein 0.663342
RBM8A RNA binding motif protein 8A 0.663342
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.663342
SNRPB2 small nuclear ribonucleoprotein polypeptide B 0.663342
PRPF4B pre-mRNA processing factor 4B 0.663342
CACTIN cactin, spliceosome C complex subunit 0.663342
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 0.663342
PLRG1 pleiotropic regulator 1 0.663342
RBMXL1 RNA binding motif protein, X-linked-like 1 0.663342
PNN pinin, desmosome associated protein 0.663342
CDC5L cell division cycle 5-like 0.663342
SRRM1 serine/arginine repetitive matrix 1 0.663342
SRRM2 serine/arginine repetitive matrix 2 0.663342
PRPF19 pre-mRNA processing factor 19 0.663342