cardiovascular calcification Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description Abnormal calcification in the cardiovascular system. (Human Phenotype Ontology, HP_0011915)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0011915
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Genes

133 genes associated with the cardiovascular calcification phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
CASR calcium-sensing receptor 2.90806
CSTA cystatin A (stefin A) 1.8889
CCDC58 coiled-coil domain containing 58 1.55113
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 1.51359
FAM162A family with sequence similarity 162, member A 1.46493
DGKD diacylglycerol kinase, delta 130kDa 1.44286
GCKR glucokinase (hexokinase 4) regulator 1.43716
CARS cysteinyl-tRNA synthetase 1.43716
PARP9 poly (ADP-ribose) polymerase family, member 9 1.3563
KPNA1 karyopherin alpha 1 (importin alpha 5) 1.34581
WDR5B WD repeat domain 5B 1.20811
CDKN2B-AS1 CDKN2B antisense RNA 1 1.17747
LPA lipoprotein, Lp(a) 1.15482
WDR81 WD repeat domain 81 1.0674
PPAP2B phosphatidic acid phosphatase type 2B 1.06514
ARID1B AT rich interactive domain 1B (SWI1-like) 1.05066
ZC3HC1 zinc finger, C3HC-type containing 1 0.997198
MIR22HG MIR22 host gene 0.977911
CD109 CD109 molecule 0.969142
C11ORF40 chromosome 11 open reading frame 40 0.952642
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 0.940413
PYGB phosphorylase, glycogen; brain 0.919744
RGS14 regulator of G-protein signaling 14 0.919744
TUBA3C tubulin, alpha 3c 0.897771
OPCML opioid binding protein/cell adhesion molecule-like 0.858993
SYT6 synaptotagmin VI 0.845618
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.844241
SOX5 SRY (sex determining region Y)-box 5 0.831588
TRIM6 tripartite motif containing 6 0.809986
PLXNA4 plexin A4 0.808534
TTC27 tetratricopeptide repeat domain 27 0.789144
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.782369
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) 0.773374
OFCC1 orofacial cleft 1 candidate 1 0.768701
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.767198
RPH3AL rabphilin 3A-like (without C2 domains) 0.752335
IRF6 interferon regulatory factor 6 0.722896
NELL1 NEL-like 1 (chicken) 0.711491
RNF152 ring finger protein 152 0.696021
FAM187B family with sequence similarity 187, member B 0.693105
ITGA11 integrin, alpha 11 0.691522
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5 0.691208
TMEM14A transmembrane protein 14A 0.688736
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.688128
ZNF415 zinc finger protein 415 0.687222
CPEB3 cytoplasmic polyadenylation element binding protein 3 0.678743
SGCZ sarcoglycan, zeta 0.671914
EGFLAM EGF-like, fibronectin type III and laminin G domains 0.671627
TUBGCP3 tubulin, gamma complex associated protein 3 0.669362
DIEXF digestive organ expansion factor homolog (zebrafish) 0.666872
ZNF676 zinc finger protein 676 0.660006
FAM13A family with sequence similarity 13, member A 0.644396
ADAM12 ADAM metallopeptidase domain 12 0.642942
DSCAM Down syndrome cell adhesion molecule 0.640797
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.638004
CNTN5 contactin 5 0.63709
STAB2 stabilin 2 0.635508
DAPK1 death-associated protein kinase 1 0.63395
CSMD1 CUB and Sushi multiple domains 1 0.624865
KDSR 3-ketodihydrosphingosine reductase 0.624865
FLT1 fms-related tyrosine kinase 1 0.623859
NCK2 NCK adaptor protein 2 0.614589
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 0.60762
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7 0.60465
ARHGAP10 Rho GTPase activating protein 10 0.595129
COL23A1 collagen, type XXIII, alpha 1 0.594038
COG5 component of oligomeric golgi complex 5 0.593421
DIRC3 disrupted in renal carcinoma 3 0.592807
PTPRB protein tyrosine phosphatase, receptor type, B 0.591289
GFRA2 GDNF family receptor alpha 2 0.584889
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 0.581386
ZPR1 ZPR1 zinc finger 0.580913
SPTBN1 spectrin, beta, non-erythrocytic 1 0.580444
MAST2 microtubule associated serine/threonine kinase 2 0.58021
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.579396
PTPN9 protein tyrosine phosphatase, non-receptor type 9 0.579049
P3H2 prolyl 3-hydroxylase 2 0.576326
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.57588
TCF21 transcription factor 21 0.57041
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 0.57041
HHIPL1 HHIP-like 1 0.468679
TBX5 T-box 5 0.460488
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.428943
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.424466
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.42375
WDR12 WD repeat domain 12 0.422699
SMG6 SMG6 nonsense mediated mRNA decay factor 0.422368
PHACTR1 phosphatase and actin regulator 1 0.422368
COL4A2 collagen, type IV, alpha 2 0.411834
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.405644
MIA3 melanoma inhibitory activity family, member 3 0.405644
UBE2Z ubiquitin-conjugating enzyme E2Z 0.404206
MRAS muscle RAS oncogene homolog 0.401061
OPTC opticin 0.363989
PCSK5 proprotein convertase subtilisin/kexin type 5 0.36298
POTEA POTE ankyrin domain family, member A 0.36125
SH2B3 SH2B adaptor protein 3 0.360424
SUFU suppressor of fused homolog (Drosophila) 0.359032
SPRR2B small proline-rich protein 2B 0.357115
ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) 0.351537
DUSP27 dual specificity phosphatase 27 (putative) 0.349785
GRID2 glutamate receptor, ionotropic, delta 2 0.349237
TRIB2 tribbles pseudokinase 2 0.347746
TMEM180 transmembrane protein 180 0.347294
UNC5B unc-5 homolog B (C. elegans) 0.345286
ANKRD36B ankyrin repeat domain 36B 0.344927
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.343
ASIC2 acid sensing (proton gated) ion channel 2 0.342683
ILDR2 immunoglobulin-like domain containing receptor 2 0.342074
FOXN3 forkhead box N3 0.341781
SLC2A14 solute carrier family 2 (facilitated glucose transporter), member 14 0.340681
SPRR2D small proline-rich protein 2D 0.339922
SPRR1B small proline-rich protein 1B 0.338983
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase 0.338542
CDH13 cadherin 13 0.338328
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.338328
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) 0.338117
UBE2K ubiquitin-conjugating enzyme E2K 0.337708
ADGRD1 adhesion G protein-coupled receptor D1 0.337314
ERBB4 erb-b2 receptor tyrosine kinase 4 0.336385
MB myoglobin 0.336208
BMPR1B bone morphogenetic protein receptor, type IB 0.335527
HOOK3 hook microtubule-tethering protein 3 0.335363
ARHGAP24 Rho GTPase activating protein 24 0.335363
SLIT1 slit homolog 1 (Drosophila) 0.334039
AGXT alanine-glyoxylate aminotransferase 0.333556
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.333556
SMOC1 SPARC related modular calcium binding 1 0.333556
E2F1 E2F transcription factor 1 0.332644
C2ORF54 chromosome 2 open reading frame 54 0.331524
PPARD peroxisome proliferator-activated receptor delta 0.331391
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.331259
FHIT fragile histidine triad 0.331