cardiac arrest Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A congestive heart failure characterized by a sudden stop in effective blood circulation due to the failure of the heart to contract effectively or at all. (Human Disease Ontology, DOID_0060319)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0001695
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Genes

311 genes associated with the cardiac arrest phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
AGXT2 alanine--glyoxylate aminotransferase 2 1.99238
DDAH1 dimethylarginine dimethylaminohydrolase 1 1.99238
KIAA1755 KIAA1755 1.69784
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 1.65584
DNAJC21 DnaJ (Hsp40) homolog, subfamily C, member 21 1.63283
CD46 CD46 molecule, complement regulatory protein 1.61591
CCDC141 coiled-coil domain containing 141 1.61591
SYT10 synaptotagmin X 1.54299
SLC35F1 solute carrier family 35, member F1 1.38847
SLC12A9 solute carrier family 12, member 9 1.37339
FADS1 fatty acid desaturase 1 1.32793
BRIX1 BRX1, biogenesis of ribosomes 1.29776
RAD1 RAD1 checkpoint DNA exonuclease 1.22604
UFSP1 UFM1-specific peptidase 1 (non-functional) 1.21853
TTC23L tetratricopeptide repeat domain 23-like 1.15175
ZNF385B zinc finger protein 385B 1.12044
MAML2 mastermind-like 2 (Drosophila) 1.05108
CHRM2 cholinergic receptor, muscarinic 2 1.04365
NKX2-5 NK2 homeobox 5 1.02229
CEP85L centrosomal protein 85kDa-like 0.950711
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.808951
SLC25A45 solute carrier family 25, member 45 0.808951
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.788376
SYDE2 synapse defective 1, Rho GTPase, homolog 2 (C. elegans) 0.778766
BCL10 B-cell CLL/lymphoma 10 0.75086
ESR1 estrogen receptor 1 0.741266
KCTD1 potassium channel tetramerization domain containing 1 0.733286
FNDC3B fibronectin type III domain containing 3B 0.719731
RFX4 regulatory factor X, 4 (influences HLA class II expression) 0.676552
CPNE8 copine VIII 0.630378
ACYP2 acylphosphatase 2, muscle type 0.522136
C1ORF52 chromosome 1 open reading frame 52 0.52022
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.515847
AP1G2 adaptor-related protein complex 1, gamma 2 subunit 0.510576
DEGS2 delta(4)-desaturase, sphingolipid 2 0.495598
LOC646626 uncharacterized LOC646626 0.480926
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.474018
FAM149B1 family with sequence similarity 149, member B1 0.473393
PDE11A phosphodiesterase 11A 0.4604
ATF1 activating transcription factor 1 0.4604
PLCE1 phospholipase C, epsilon 1 0.450694
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 0.450694
ARL5B ADP-ribosylation factor-like 5B 0.450694
MARCH10 membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase 0.450694
LOC650157 0.437499
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 0.437499
PARP4 poly (ADP-ribose) polymerase family, member 4 0.433116
COL24A1 collagen, type XXIV, alpha 1 0.431969
CPNE5 copine V 0.426113
SNX29 sorting nexin 29 0.424122
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.424122
PEBP4 phosphatidylethanolamine-binding protein 4 0.424122
CISD2 CDGSH iron sulfur domain 2 0.424122
ERBB4 erb-b2 receptor tyrosine kinase 4 0.424122
HAVCR2 hepatitis A virus cellular receptor 2 0.423749
TMEM135 transmembrane protein 135 0.421823
PADI3 peptidyl arginine deiminase, type III 0.421658
SPEF2 sperm flagellar 2 0.416878
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.413807
RNF103-CHMP3 RNF103-CHMP3 readthrough 0.413807
CLSTN2 calsyntenin 2 0.413807
ACTN4 actinin, alpha 4 0.413807
SUSD1 sushi domain containing 1 0.412215
SLC10A7 solute carrier family 10, member 7 0.411088
CNTN5 contactin 5 0.410507
ADAM17 ADAM metallopeptidase domain 17 0.410331
ZCCHC24 zinc finger, CCHC domain containing 24 0.410331
SIN3A SIN3 transcription regulator family member A 0.410331
SYCP2L synaptonemal complex protein 2-like 0.410331
RAP1GAP2 RAP1 GTPase activating protein 2 0.410331
ARHGAP25 Rho GTPase activating protein 25 0.410331
GIGYF1 GRB10 interacting GYF protein 1 0.409782
OFCC1 orofacial cleft 1 candidate 1 0.40908
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.408598
KIAA1715 KIAA1715 0.408446
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 0.408206
RSPH6A radial spoke head 6 homolog A (Chlamydomonas) 0.408206
CLCNKA chloride channel, voltage-sensitive Ka 0.407432
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.407145
THSD4 thrombospondin, type I, domain containing 4 0.406588
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.406588
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.406588
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.405267
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.405267
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 0.405267
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.405267
CHL1 cell adhesion molecule L1-like 0.405267
RAI14 retinoic acid induced 14 0.404255
OSBP2 oxysterol binding protein 2 0.404188
GPC6 glypican 6 0.40409
DCP1A decapping mRNA 1A 0.40409
LRP1B low density lipoprotein receptor-related protein 1B 0.40409
ZNF536 zinc finger protein 536 0.40409
TMEM26 transmembrane protein 26 0.40409
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 0.40409
MCOLN2 mucolipin 2 0.403939
SMAD3 SMAD family member 3 0.403226
EPC1 enhancer of polycomb homolog 1 (Drosophila) 0.403073
PYGB phosphorylase, glycogen; brain 0.403073
CDH13 cadherin 13 0.403073
IAH1 isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae) 0.402665
DAB2IP DAB2 interacting protein 0.402177
TMEM132D transmembrane protein 132D 0.402177
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.401855
FABP7 fatty acid binding protein 7, brain 0.401807
CA10 carbonic anhydrase X 0.401275
EFNA5 ephrin-A5 0.401117
PTPRT protein tyrosine phosphatase, receptor type, T 0.401039
ARRB1 arrestin, beta 1 0.400885
PRKCA protein kinase C, alpha 0.400441
PRKG1 protein kinase, cGMP-dependent, type I 0.399953
MAPK1 mitogen-activated protein kinase 1 0.399753
ZNF385D zinc finger protein 385D 0.39918
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.39918
DOCK4 dedicator of cytokinesis 4 0.398533
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.398201
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 0.397703
NGEF neuronal guanine nucleotide exchange factor 0.397197
CHD6 chromodomain helicase DNA binding protein 6 0.396719
CMYA5 cardiomyopathy associated 5 0.396565
KIAA1549L KIAA1549-like 0.396514
PIEZO2 piezo-type mechanosensitive ion channel component 2 0.396363
ARID5B AT rich interactive domain 5B (MRF1-like) 0.395927
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.395927
LDLRAD4 low density lipoprotein receptor class A domain containing 4 0.395647
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.395421
ELAVL2 ELAV like neuron-specific RNA binding protein 2 0.395288
TP73 tumor protein p73 0.39507
WDR86 WD repeat domain 86 0.395027
RSAD2 radical S-adenosyl methionine domain containing 2 0.395027
LGALS4 lectin, galactoside-binding, soluble, 4 0.394942
CNPY3 canopy FGF signaling regulator 3 0.394858
ASS1 argininosuccinate synthase 1 0.394816
C5ORF56 chromosome 5 open reading frame 56 0.394774
EPT1 ethanolaminephosphotransferase 1 0.394368
LDAH lipid droplet associated hydrolase 0.394329
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 0.394095
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.394018
LPAR6 lysophosphatidic acid receptor 6 0.393472
NCEH1 neutral cholesterol ester hydrolase 1 0.393131
TK1 thymidine kinase 1, soluble 0.392761
PTK2 protein tyrosine kinase 2 0.39268
MYH11 myosin, heavy chain 11, smooth muscle 0.392209
MAP2 microtubule-associated protein 2 0.392209
ANKRD33B ankyrin repeat domain 33B 0.391906
MBD5 methyl-CpG binding domain protein 5 0.391758
PLSCR4 phospholipid scramblase 4 0.391648
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.391396
ZFPM2 zinc finger protein, FOG family member 2 0.391081
CADPS Ca++-dependent secretion activator 0.390708
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.390252
PARP12 poly (ADP-ribose) polymerase family, member 12 0.390094
PART1 prostate androgen-regulated transcript 1 (non-protein coding) 0.390063
C1S complement component 1, s subcomponent 0.389455
CDHR3 cadherin-related family member 3 0.388936
VWA3B von Willebrand factor A domain containing 3B 0.388604
WBSCR17 Williams-Beuren syndrome chromosome region 17 0.38833
EBF1 early B-cell factor 1 0.388235
SLC38A8 solute carrier family 38, member 8 0.388111
CSMD1 CUB and Sushi multiple domains 1 0.388019
RALYL RALY RNA binding protein-like 0.387927
TENM4 teneurin transmembrane protein 4 0.387836
NFIB nuclear factor I/B 0.387836
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 0.387246
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 0.387246
MCPH1 microcephalin 1 0.387074
LAMA1 laminin, alpha 1 0.386961
KLHL21 kelch-like family member 21 0.386793
MTPN myotrophin 0.386738
KCNIP4 Kv channel interacting protein 4 0.386655
FAM155A family with sequence similarity 155, member A 0.3866
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 0.386383
USP6NL USP6 N-terminal like 0.386303
CPQ carboxypeptidase Q 0.38617
SEC31B SEC31 homolog B (S. cerevisiae) 0.386144
KLHL1 kelch-like family member 1 0.385935
TCF21 transcription factor 21 0.385832
ALK anaplastic lymphoma receptor tyrosine kinase 0.385832
TGFB2 transforming growth factor, beta 2 0.385679
LINGO2 leucine rich repeat and Ig domain containing 2 0.384634
TMEM87B transmembrane protein 87B 0.384634
ITGA1 integrin, alpha 1 0.384133
NCOA1 nuclear receptor coactivator 1 0.383933
ORC4 origin recognition complex, subunit 4 0.383587
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.383544
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 0.383417
PPP2R2B protein phosphatase 2, regulatory subunit B, beta 0.383146
ITGA9 integrin, alpha 9 0.383126
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) 0.383064
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.383044
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.382901
CYFIP2 cytoplasmic FMR1 interacting protein 2 0.382761
RAB40C RAB40C, member RAS oncogene family 0.382741
EML6 echinoderm microtubule associated protein like 6 0.382622
ACTA2 actin, alpha 2, smooth muscle, aorta 0.382394
SGCZ sarcoglycan, zeta 0.382228
ALG9 ALG9, alpha-1,2-mannosyltransferase 0.382024
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) 0.381724
NKAIN2 Na+/K+ transporting ATPase interacting 2 0.381586
FSTL1 follistatin-like 1 0.381547
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q 0.38103
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.380844
SSUH2 ssu-2 homolog (C. elegans) 0.380715
LAMB1 laminin, beta 1 0.380354
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H 0.380336
PTPRM protein tyrosine phosphatase, receptor type, M 0.380212
TASP1 taspase, threonine aspartase, 1 0.380124
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase) 0.379864
FAS Fas cell surface death receptor 0.379847
COL13A1 collagen, type XIII, alpha 1 0.379677
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.379677
UBE3C ubiquitin protein ligase E3C 0.379426
ZBTB16 zinc finger and BTB domain containing 16 0.379409
BLOC1S5-TXNDC5 BLOC1S5-TXNDC5 readthrough (NMD candidate) 0.379245
TMEM232 transmembrane protein 232 0.379163
RNLS renalase, FAD-dependent amine oxidase 0.379002
ANTXR1 anthrax toxin receptor 1 0.378843
KRT13 keratin 13, type I 0.378748
ZNF516 zinc finger protein 516 0.378623
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.378406
CLMN calmin (calponin-like, transmembrane) 0.3783
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.3783
NCALD neurocalcin delta 0.378239
TRIM67 tripartite motif containing 67 0.378164
SEPT9 septin 9 0.378164
OPCML opioid binding protein/cell adhesion molecule-like 0.377866
DLG2 discs, large homolog 2 (Drosophila) 0.377808
GRM5 glutamate receptor, metabotropic 5 0.377793
VAV3 vav 3 guanine nucleotide exchange factor 0.377691
CD48 CD48 molecule 0.377447
TRPM5 transient receptor potential cation channel, subfamily M, member 5 0.377264
FAXC failed axon connections homolog (Drosophila) 0.377208
HEG1 heart development protein with EGF-like domains 1 0.37718
TMC3 transmembrane channel-like 3 0.377166
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 0.377083
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 0.377069
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.377055
SORBS1 sorbin and SH3 domain containing 1 0.376528
LOC285768 uncharacterized LOC285768 0.376396
ROR2 receptor tyrosine kinase-like orphan receptor 2 0.374594
RBM20 RNA binding motif protein 20 0.374373
IDE insulin-degrading enzyme 0.374263
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 0.374263
NLRP11 NLR family, pyrin domain containing 11 0.372824
MYO16 myosin XVI 0.372824
NRG3 neuregulin 3 0.37207
ZEB2 zinc finger E-box binding homeobox 2 0.371799
PCNXL2 pecanex-like 2 (Drosophila) 0.371621
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.371446
PCSK5 proprotein convertase subtilisin/kexin type 5 0.371187
OCA2 oculocutaneous albinism II 0.370934
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 0.370851
SPEG SPEG complex locus 0.370604
SPHKAP SPHK1 interactor, AKAP domain containing 0.370283
ADORA3 adenosine A3 receptor 0.370204
LOC100131691 0.369287
HTRA1 HtrA serine peptidase 1 0.369068
LOC441035 uncharacterized LOC441035 0.368924
LOC283177 uncharacterized LOC283177 0.368853
TET3 tet methylcytosine dioxygenase 3 0.368502
LYAR Ly1 antibody reactive 0.368093
FLJ37453 uncharacterized LOC729614 0.367189
NAV2 neuron navigator 2 0.367189
CRYAB crystallin, alpha B 0.366942
SOAT1 sterol O-acyltransferase 1 0.366001
CENPO centromere protein O 0.365832
FAM19A2 family with sequence similarity 19 (chemokine (C-C motif)-like), member A2 0.365286
SCN10A sodium channel, voltage gated, type X alpha subunit 0.364865
POU6F2 POU class 6 homeobox 2 0.364711
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7 0.364458
FAM47E family with sequence similarity 47, member E 0.364408
LAPTM4B lysosomal protein transmembrane 4 beta 0.364162
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3 0.364064
NACA nascent polypeptide-associated complex alpha subunit 0.363055
PRPF3 pre-mRNA processing factor 3 0.362862
NCKIPSD NCK interacting protein with SH3 domain 0.362485
FXN frataxin 0.362392
DHX33 DEAH (Asp-Glu-Ala-His) box polypeptide 33 0.362028
OR2L13 olfactory receptor, family 2, subfamily L, member 13 0.361499
WT1 Wilms tumor 1 0.361456
WNK2 WNK lysine deficient protein kinase 2 0.360743
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.36054
FSTL5 follistatin-like 5 0.360105
SNTG1 syntrophin, gamma 1 0.359609
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 0.359386
EPHB1 EPH receptor B1 0.359167
OR1I1 olfactory receptor, family 1, subfamily I, member 1 0.359059
TLK1 tousled-like kinase 1 0.359023
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.358635
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 0.358565
CDH8 cadherin 8, type 2 0.358462
PRDM16 PR domain containing 16 0.358291
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 0.358257
IGFBP7 insulin-like growth factor binding protein 7 0.357825
DARS aspartyl-tRNA synthetase 0.357792
C8ORF34 chromosome 8 open reading frame 34 0.357727
ABAT 4-aminobutyrate aminotransferase 0.357422
IRS1 insulin receptor substrate 1 0.357352
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.357318
SPTA1 spectrin, alpha, erythrocytic 1 0.357214
IP6K2 inositol hexakisphosphate kinase 2 0.357077
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) 0.35654
HGD homogentisate 1,2-dioxygenase 0.356475
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.356312
CHRM3 cholinergic receptor, muscarinic 3 0.356247
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 0.356119
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 0.355072
MSI1 musashi RNA-binding protein 1 0.353027
PPP4C protein phosphatase 4, catalytic subunit 0.350337
NAE1 NEDD8 activating enzyme E1 subunit 1 0.348346
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 0.347085