captopril-4585 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the captopril-4585 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALOXE3 arachidonate lipoxygenase 3
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AMPH amphiphysin
AP2S1 adaptor-related protein complex 2, sigma 1 subunit
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARTN artemin
ASIC3 acid sensing (proton gated) ion channel 3
ATP10A ATPase, class V, type 10A
B3GAT1 beta-1,3-glucuronyltransferase 1
C10ORF10 chromosome 10 open reading frame 10
C14ORF105 chromosome 14 open reading frame 105
C8A complement component 8, alpha polypeptide
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CAMK4 calcium/calmodulin-dependent protein kinase IV
CCDC28B coiled-coil domain containing 28B
CD52 CD52 molecule
CDC5L cell division cycle 5-like
CDK2 cyclin-dependent kinase 2
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLCN6 chloride channel, voltage-sensitive 6
CNN2 calponin 2
COL7A1 collagen, type VII, alpha 1
COMMD4 COMM domain containing 4
CTSZ cathepsin Z
DAPK2 death-associated protein kinase 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
DMBT1 deleted in malignant brain tumors 1
DMP1 dentin matrix acidic phosphoprotein 1
DRD2 dopamine receptor D2
DSG3 desmoglein 3
EIF5A eukaryotic translation initiation factor 5A
ESRRG estrogen-related receptor gamma
FAM174B family with sequence similarity 174, member B
FAM182B family with sequence similarity 182, member B
FGA fibrinogen alpha chain
FGF5 fibroblast growth factor 5
FZD1 frizzled class receptor 1
GAN gigaxonin
GPNMB glycoprotein (transmembrane) nmb
GPR3 G protein-coupled receptor 3
GSTTP1 glutathione S-transferase theta pseudogene 1
HNF1B HNF1 homeobox B
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HOXC5 homeobox C5
HPR haptoglobin-related protein
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
KLHDC8A kelch domain containing 8A
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LRRK1 leucine-rich repeat kinase 1
LTBP4 latent transforming growth factor beta binding protein 4
MCM4 minichromosome maintenance complex component 4
MORC1 MORC family CW-type zinc finger 1
MTA2 metastasis associated 1 family, member 2
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NCF4 neutrophil cytosolic factor 4, 40kDa
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NNAT neuronatin
NPIPB15 nuclear pore complex interacting protein family, member B15
PDPN podoplanin
PEX16 peroxisomal biogenesis factor 16
PHLDB1 pleckstrin homology-like domain, family B, member 1
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PMS2P4 postmeiotic segregation increased 2 pseudogene 4
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PPP4R4 protein phosphatase 4, regulatory subunit 4
PRAMEF11 PRAME family member 11
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PYY peptide YY
RAB2A RAB2A, member RAS oncogene family
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RPL10L ribosomal protein L10-like
RPL13 ribosomal protein L13
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SMR3A submaxillary gland androgen regulated protein 3A
SOS2 son of sevenless homolog 2 (Drosophila)
STAT2 signal transducer and activator of transcription 2, 113kDa
STATH statherin
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCOF1 Treacher Collins-Franceschetti syndrome 1
TEF thyrotrophic embryonic factor
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TPMT thiopurine S-methyltransferase
TRAF3IP3 TRAF3 interacting protein 3
TRIM16 tripartite motif containing 16
TTC12 tetratricopeptide repeat domain 12
TTLL1 tubulin tyrosine ligase-like family member 1
VWA5A von Willebrand factor A domain containing 5A
WNT6 wingless-type MMTV integration site family, member 6
WT1 Wilms tumor 1

decreased expression

Symbol Name
ADAM15 ADAM metallopeptidase domain 15
ANKRD11 ankyrin repeat domain 11
ANKRD36B ankyrin repeat domain 36B
ARL5A ADP-ribosylation factor-like 5A
ASAP1-IT1 ASAP1 intronic transcript 1
ASRGL1 asparaginase like 1
BARD1 BRCA1 associated RING domain 1
BBX bobby sox homolog (Drosophila)
CCDC15 coiled-coil domain containing 15
CCNI cyclin I
CCNT1 cyclin T1
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
CXADR coxsackie virus and adenovirus receptor
DCAF16 DDB1 and CUL4 associated factor 16
DCBLD2 discoidin, CUB and LCCL domain containing 2
DENND5B DENN/MADD domain containing 5B
DEPDC1 DEP domain containing 1
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
FAM169A family with sequence similarity 169, member A
FICD FIC domain containing
FKBP10 FK506 binding protein 10, 65 kDa
FNDC3B fibronectin type III domain containing 3B
FOXO3 forkhead box O3
FZD8 frizzled class receptor 8
GLI3 GLI family zinc finger 3
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUSBP3 glucuronidase, beta pseudogene 3
HELLS helicase, lymphoid-specific
HMBOX1 homeobox containing 1
HOXA5 homeobox A5
ING3 inhibitor of growth family, member 3
IPP intracisternal A particle-promoted polypeptide
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
LOC100272216 uncharacterized LOC100272216
MAN2A1 mannosidase, alpha, class 2A, member 1
MAVS mitochondrial antiviral signaling protein
MED1 mediator complex subunit 1
METTL8 methyltransferase like 8
MIS18BP1 MIS18 binding protein 1
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NFIC nuclear factor I/C (CCAAT-binding transcription factor)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NINJ1 ninjurin 1
NPM3 nucleophosmin/nucleoplasmin 3
NR1D2 nuclear receptor subfamily 1, group D, member 2
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
OXR1 oxidation resistance 1
PCYOX1 prenylcysteine oxidase 1
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PHACTR2 phosphatase and actin regulator 2
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
POGLUT1 protein O-glucosyltransferase 1
POLR1B polymerase (RNA) I polypeptide B, 128kDa
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PSAT1 phosphoserine aminotransferase 1
PTER phosphotriesterase related
RAD54L2 RAD54-like 2 (S. cerevisiae)
RBM41 RNA binding motif protein 41
RPL13P5 ribosomal protein L13 pseudogene 5
RSRC1 arginine/serine-rich coiled-coil 1
SCRN3 secernin 3
SCYL2 SCY1-like 2 (S. cerevisiae)
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC38A1 solute carrier family 38, member 1
SLIT2 slit homolog 2 (Drosophila)
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SPIN1 spindlin 1
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYNJ2BP synaptojanin 2 binding protein
TCAF1 TRPM8 channel-associated factor 1
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
THOC2 THO complex 2
TIPRL TOR signaling pathway regulator
TMEM260 transmembrane protein 260
TSPAN5 tetraspanin 5
TTBK2 tau tubulin kinase 2
UBE2W ubiquitin-conjugating enzyme E2W (putative)
UGCG UDP-glucose ceramide glucosyltransferase
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
VASH2 vasohibin 2
WWC2 WW and C2 domain containing 2
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZBTB38 zinc finger and BTB domain containing 38
ZC2HC1A zinc finger, C2HC-type containing 1A
ZNF12 zinc finger protein 12
ZNF148 zinc finger protein 148
ZNF264 zinc finger protein 264
ZNF652 zinc finger protein 652
ZNF654 zinc finger protein 654
ZNF91 zinc finger protein 91
ZWILCH zwilch kinetochore protein