|Dataset||GO Molecular Function Annotations|
|Category||structural or functional annotations|
|Description||Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families. (Gene Ontology, GO_0004662)|
|Downloads & Tools|
2 genes performing the caax-protein geranylgeranyltransferase activity molecular function from the curated GO Molecular Function Annotations dataset.