breaks Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

179 genes co-occuring with the biological term breaks in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADM adrenomedullin
AGO2 argonaute RISC catalytic component 2
AICDA activation-induced cytidine deaminase
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALKBH2 alkB, alkylation repair homolog 2 (E. coli)
APC adenomatous polyposis coli
APLF aprataxin and PNKP like factor
APOB apolipoprotein B
APTX aprataxin
ATAD5 ATPase family, AAA domain containing 5
ATM ATM serine/threonine kinase
ATMIN ATM interactor
ATR ATR serine/threonine kinase
AURKA aurora kinase A
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCCIP BRCA2 and CDKN1A interacting protein
BCL2 B-cell CLL/lymphoma 2
BCL6 B-cell CLL/lymphoma 6
BLM Bloom syndrome, RecQ helicase-like
BMI1 BMI1 proto-oncogene, polycomb ring finger
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
CCL2 chemokine (C-C motif) ligand 2
CCL21 chemokine (C-C motif) ligand 21
CCNA2 cyclin A2
CCND1 cyclin D1
CDC25A cell division cycle 25A
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDT1 chromatin licensing and DNA replication factor 1
CENPA centromere protein A
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CSNK2B casein kinase 2, beta polypeptide
CUL4A cullin 4A
CUL4B cullin 4B
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DCLRE1B DNA cross-link repair 1B
DCLRE1C DNA cross-link repair 1C
DDA1 DET1 and DDB1 associated 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1
DNASE1L3 deoxyribonuclease I-like 3
E2F1 E2F transcription factor 1
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
ERCC4 excision repair cross-complementation group 4
ERCC5 excision repair cross-complementation group 5
ERCC6 excision repair cross-complementation group 6
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ESR1 estrogen receptor 1
EXO1 exonuclease 1
F8 coagulation factor VIII, procoagulant component
FANCC Fanconi anemia, complementation group C
FANCD2 Fanconi anemia, complementation group D2
FANCG Fanconi anemia, complementation group G
FANCM Fanconi anemia, complementation group M
FAS Fas cell surface death receptor
FBXO18 F-box protein, helicase, 18
FHIT fragile histidine triad
FRA16D fragile site, aphidicolin type, common, fra(16)(q23.2)
FRA1E fragile site, aphidicolin type, common, fra(1)(p21.2)
GSTT1 glutathione S-transferase theta 1
H2AFX H2A histone family, member X
H2AFY H2A histone family, member Y
H2AFZ H2A histone family, member Z
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HIST2H2AA3 histone cluster 2, H2aa3
HIST3H2BB histone cluster 3, H2bb
HIST4H4 histone cluster 4, H4
HMGA2 high mobility group AT-hook 2
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2
HTT huntingtin
IFNB1 interferon, beta 1, fibroblast
IL1B interleukin 1, beta
KAT5 K(lysine) acetyltransferase 5
KMT2A lysine (K)-specific methyltransferase 2A
LIG1 ligase I, DNA, ATP-dependent
LIG4 ligase IV, DNA, ATP-dependent
LMNA lamin A/C
LYN LYN proto-oncogene, Src family tyrosine kinase
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MCM4 minichromosome maintenance complex component 4
MCPH1 microcephalin 1
MDC1 mediator of DNA-damage checkpoint 1
MIR18A microRNA 18a
MIR200C microRNA 200c
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MTA1 metastasis associated 1
MUS81 MUS81 structure-specific endonuclease subunit
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NHEJ1 nonhomologous end-joining factor 1
NOS2 nitric oxide synthase 2, inducible
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRG1 neuregulin 1
NTHL1 nth endonuclease III-like 1 (E. coli)
NTM neurotrimin
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OAZ1 ornithine decarboxylase antizyme 1
OGG1 8-oxoguanine DNA glycosylase
ORC1 origin recognition complex, subunit 1
PARP1 poly (ADP-ribose) polymerase 1
PARP3 poly (ADP-ribose) polymerase family, member 3
PCNA proliferating cell nuclear antigen
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PNKP polynucleotide kinase 3'-phosphatase
POLB polymerase (DNA directed), beta
POLH polymerase (DNA directed), eta
POLL polymerase (DNA directed), lambda
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRNP prion protein
PSME4 proteasome (prosome, macropain) activator subunit 4
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAD17 RAD17 homolog (S. pombe)
RAD50 RAD50 homolog (S. cerevisiae)
RAD51 RAD51 recombinase
RAD52 RAD52 homolog (S. cerevisiae)
RAG1 recombination activating gene 1
RBBP8 retinoblastoma binding protein 8
RBX1 ring-box 1, E3 ubiquitin protein ligase
RECQL4 RecQ protein-like 4
RECQL5 RecQ protein-like 5
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RPA1 replication protein A1, 70kDa
RPA2 replication protein A2, 32kDa
SAFB scaffold attachment factor B
SETX senataxin
SLC31A1 solute carrier family 31 (copper transporter), member 1
SMC5 structural maintenance of chromosomes 5
SMC6 structural maintenance of chromosomes 6
SOCS1 suppressor of cytokine signaling 1
SRSF1 serine/arginine-rich splicing factor 1
SSBP1 single-stranded DNA binding protein 1, mitochondrial
STK11 serine/threonine kinase 11
SUMO1 small ubiquitin-like modifier 1
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)
TCOF1 Treacher Collins-Franceschetti syndrome 1
TDG thymine-DNA glycosylase
TDP1 tyrosyl-DNA phosphodiesterase 1
TERF2 telomeric repeat binding factor 2
TERT telomerase reverse transcriptase
THOC1 THO complex 1
TLK1 tousled-like kinase 1
TLK2 tousled-like kinase 2
TMPRSS2 transmembrane protease, serine 2
TOP1 topoisomerase (DNA) I
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TPMT thiopurine S-methyltransferase
TRAF3 TNF receptor-associated factor 3
TRIM28 tripartite motif containing 28
TRRAP transformation/transcription domain-associated protein
UBA1 ubiquitin-like modifier activating enzyme 1
UIMC1 ubiquitin interaction motif containing 1
UNG uracil-DNA glycosylase
WRN Werner syndrome, RecQ helicase-like
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YBX1 Y box binding protein 1