brca1-c complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A protein complex that contains the BRCA1-BARD1 heterodimer, CtIP and Mre11/Rad50/NBS1 (M/R/N) complex, and binds to DNA at DNA damage sites. BRCA1-C binding ta damaged DNA is required for DNA damage-induced Chk1 phosphorylation and the G2/M transition checkpoint. (Gene Ontology, GO_0070533)
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Genes

72 proteins co-occuring with the brca1-c complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
BRCA1 breast cancer 1, early onset 2.41333
BRCA2 breast cancer 2, early onset 1.7063
MCPH1 microcephalin 1 1.28569
POLL polymerase (DNA directed), lambda 1.2777
REV1 REV1, polymerase (DNA directed) 1.09594
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 1.06246
TOPBP1 topoisomerase (DNA) II binding protein 1 1.05942
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 0.981473
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.979044
PAPD7 PAP associated domain containing 7 0.961187
RBBP8 retinoblastoma binding protein 8 0.920449
BARD1 BRCA1 associated RING domain 1 0.913909
EYA3 EYA transcriptional coactivator and phosphatase 3 0.883321
PES1 pescadillo ribosomal biogenesis factor 1 0.879633
H2AFX H2A histone family, member X 0.847451
MDC1 mediator of DNA-damage checkpoint 1 0.83781
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) 0.714126
ATM ATM serine/threonine kinase 0.699543
SLX4 SLX4 structure-specific endonuclease subunit 0.687264
WDR12 WD repeat domain 12 0.639289
ZBTB17 zinc finger and BTB domain containing 17 0.621379
CRB2 crumbs family member 2 0.620529
LIG3 ligase III, DNA, ATP-dependent 0.582176
ECT2 epithelial cell transforming 2 0.575912
ACACA acetyl-CoA carboxylase alpha 0.570913
PNKP polynucleotide kinase 3'-phosphatase 0.561358
ATR ATR serine/threonine kinase 0.5597
TOP2B topoisomerase (DNA) II beta 180kDa 0.550186
NABP2 nucleic acid binding protein 2 0.537005
PARP1 poly (ADP-ribose) polymerase 1 0.536594
CDC27 cell division cycle 27 0.49418
CHEK2 checkpoint kinase 2 0.486904
EYA1 EYA transcriptional coactivator and phosphatase 1 0.457208
APTX aprataxin 0.449245
BRAP BRCA1 associated protein 0.448451
PARP2 poly (ADP-ribose) polymerase 2 0.438146
RAD50 RAD50 homolog (S. cerevisiae) 0.435775
TP73 tumor protein p73 0.427104
SUMO3 small ubiquitin-like modifier 3 0.42082
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 0.418077
PRDM2 PR domain containing 2, with ZNF domain 0.405971
ACYP2 acylphosphatase 2, muscle type 0.405193
SUMO2 small ubiquitin-like modifier 2 0.404804
ACYP1 acylphosphatase 1, erythrocyte (common) type 0.404026
RFC3 replication factor C (activator 1) 3, 38kDa 0.392775
RFC5 replication factor C (activator 1) 5, 36.5kDa 0.390455
RFC4 replication factor C (activator 1) 4, 37kDa 0.389296
PALB2 partner and localizer of BRCA2 0.378122
RFC1 replication factor C (activator 1) 1, 145kDa 0.37045
NBPF1 neuroblastoma breakpoint family, member 1 0.358228
RFC2 replication factor C (activator 1) 2, 40kDa 0.340773
PIAS4 protein inhibitor of activated STAT, 4 0.304027
BOC BOC cell adhesion associated, oncogene regulated 0.301797
DNTT DNA nucleotidylexotransferase 0.29994
SMC5 structural maintenance of chromosomes 5 0.279245
RACGAP1 Rac GTPase activating protein 1 0.278877
TP53 tumor protein p53 0.272267
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.264215
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.259473
FHL2 four and a half LIM domains 2 0.240276
ALYREF Aly/REF export factor 0.228464
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.228108
ATRIP ATR interacting protein 0.227041
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.208825
PCNA proliferating cell nuclear antigen 0.195353
DBF4 DBF4 zinc finger 0.190175
UBE2D2 ubiquitin-conjugating enzyme E2D 2 0.183935
LGALS4 lectin, galactoside-binding, soluble, 4 0.181227
CHD4 chromodomain helicase DNA binding protein 4 0.179167
PRMT1 protein arginine methyltransferase 1 0.170888
KARS lysyl-tRNA synthetase 0.169604
CDK7 cyclin-dependent kinase 7 0.164089