brca1-a complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites. (Gene Ontology, GO_0070531)
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38 proteins co-occuring with the brca1-a complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
UIMC1 ubiquitin interaction motif containing 1 2.17272
BABAM1 BRISC and BRCA1 A complex member 1 2.06632
BRCA1 breast cancer 1, early onset 1.64493
BRE brain and reproductive organ-expressed (TNFRSF1A modulator) 1.13318
BARD1 BRCA1 associated RING domain 1 1.10919
MAGED2 melanoma antigen family D2 1.08019
FAM175B family with sequence similarity 175, member B 1.07005
ELK1 ELK1, member of ETS oncogene family 1.00645
KCNH6 potassium channel, voltage gated eag related subfamily H, member 6 0.976619
TEN1 TEN1 CST complex subunit 0.945432
RNF8 ring finger protein 8, E3 ubiquitin protein ligase 0.896257
E2F5 E2F transcription factor 5, p130-binding 0.673328
RNF168 ring finger protein 168, E3 ubiquitin protein ligase 0.610355
E2F3 E2F transcription factor 3 0.590553
UBE2N ubiquitin-conjugating enzyme E2N 0.458803
MDC1 mediator of DNA-damage checkpoint 1 0.423567
E2F4 E2F transcription factor 4, p107/p130-binding 0.410259
ANGPT1 angiopoietin 1 0.366623
SUMO3 small ubiquitin-like modifier 3 0.362422
SUMO2 small ubiquitin-like modifier 2 0.346829
CDK6 cyclin-dependent kinase 6 0.301425
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.273
GSTM2 glutathione S-transferase mu 2 (muscle) 0.227041
RAD50 RAD50 homolog (S. cerevisiae) 0.196999
H2AFJ H2A histone family, member J 0.186087
HIST1H2AD histone cluster 1, H2ad 0.186087
HIST1H2AJ histone cluster 1, H2aj 0.186087
HIST1H2AM histone cluster 1, H2am 0.185777
HIST1H2AH histone cluster 1, H2ah 0.185777
HIST1H2AG histone cluster 1, H2ag 0.184853
H2AFY2 H2A histone family, member Y2 0.183328
HIST1H2AE histone cluster 1, H2ae 0.183025
HIST1H2AB histone cluster 1, H2ab 0.183025
H2AFV H2A histone family, member V 0.182723
H2AFB1 H2A histone family, member B1 0.180339
H2AFB2 H2A histone family, member B2 0.178011
H2AFY H2A histone family, member Y 0.175466
BRCA2 breast cancer 2, early onset 0.173273