brca1-a complex Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites. (Gene Ontology, GO_0070531)
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7 proteins localized to the brca1-a complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
BABAM1 BRISC and BRCA1 A complex member 1 0.663342
BARD1 BRCA1 associated RING domain 1 0.663342
BRCA1 breast cancer 1, early onset 0.663342
BRE brain and reproductive organ-expressed (TNFRSF1A modulator) 0.663342
BRCC3 BRCA1/BRCA2-containing complex, subunit 3 0.663342
UIMC1 ubiquitin interaction motif containing 1 0.663342
FAM175A family with sequence similarity 175, member A 0.663342
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