bone resorption disease Gene Set

Dataset DISEASES Experimental Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A bone remodeling disease that results in an abnormal decrease of bone density or mass. (Human Disease Ontology, DOID_0080011)
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Genes

128 genes associated with the disease bone resorption disease in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 1.75714
MEPE matrix extracellular phosphoglycoprotein 1.65491
FAM3C family with sequence similarity 3, member C 1.65491
LRP5 low density lipoprotein receptor-related protein 5 1.61356
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.57113
C17ORF53 chromosome 17 open reading frame 53 1.53808
FUBP3 far upstream element (FUSE) binding protein 3 1.45684
JAG1 jagged 1 1.31515
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 1.30486
SMG6 SMG6 nonsense mediated mRNA decay factor 1.2894
C2ORF73 chromosome 2 open reading frame 73 1.27521
AKAP11 A kinase (PRKA) anchor protein 11 1.22898
CLCN7 chloride channel, voltage-sensitive 7 1.17894
WNT4 wingless-type MMTV integration site family, member 4 1.17894
AXIN1 axin 1 1.17894
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) 1.14929
MARK3 MAP/microtubule affinity-regulating kinase 3 1.11998
HOXC4 homeobox C4 1.10381
HOXC6 homeobox C6 1.10381
WNT16 wingless-type MMTV integration site family, member 16 1.09588
DHH desert hedgehog 1.09588
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 1.07383
IDUA iduronidase, alpha-L- 1.04495
COLEC10 collectin sub-family member 10 (C-type lectin) 1.03485
DNM3 dynamin 3 1.02774
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.00628
MEF2C myocyte enhancer factor 2C 0.965481
WLS wntless Wnt ligand secretion mediator 0.932337
NME8 NME/NM23 family member 8 0.910378
GPR141 G protein-coupled receptor 141 0.910378
KLHL42 kelch-like family member 42 0.872896
RPS12 ribosomal protein S12 0.85991
LEKR1 leucine, glutamate and lysine rich 1 0.850113
SHFM1 split hand/foot malformation (ectrodactyly) type 1 0.842276
DCDC5 doublecortin domain containing 5 0.790827
SOX9 SRY (sex determining region Y)-box 9 0.790827
MAPT microtubule-associated protein tau 0.752991
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.745324
GPATCH1 G patch domain containing 1 0.738873
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.724323
CPED1 cadherin-like and PC-esterase domain containing 1 0.724323
INSIG2 insulin induced gene 2 0.724323
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.69843
TRHR thyrotropin-releasing hormone receptor 0.670996
KIAA2018 KIAA2018 0.670996
CPN1 carboxypeptidase N, polypeptide 1 0.63666
CCDC170 coiled-coil domain containing 170 0.63207
PKDCC protein kinase domain containing, cytoplasmic 0.63207
TMEM263 transmembrane protein 263 0.63207
SFRP4 secreted frizzled-related protein 4 0.63207
FMN2 formin 2 0.602429
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 0.602429
ANAPC1 anaphase promoting complex subunit 1 0.602429
DCDC1 doublecortin domain containing 1 0.602429
ARHGAP1 Rho GTPase activating protein 1 0.572184
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2 0.544585
CRHR1 corticotropin releasing hormone receptor 1 0.52461
SPTBN1 spectrin, beta, non-erythrocytic 1 0.486425
ESR1 estrogen receptor 1 0.486425
GLYAT glycine-N-acyltransferase 0.486425
C2ORF69 chromosome 2 open reading frame 69 0.486425
HDAC5 histone deacetylase 5 0.486425
SOST sclerostin 0.486425
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 0.486425
RSPO3 R-spondin 3 0.464771
MECOM MDS1 and EVI1 complex locus 0.449873
RAP1A RAP1A, member of RAS oncogene family 0.449873
LIN7C lin-7 homolog C (C. elegans) 0.438544
FAM210A family with sequence similarity 210, member A 0.438544
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.403461
SP7 Sp7 transcription factor 0.403461
NRG1 neuregulin 1 0.368757
ADGRV1 adhesion G protein-coupled receptor V1 0.368757
XKR9 XK, Kell blood group complex subunit-related family, member 9 0.368757
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.345945
PLCL1 phospholipase C-like 1 0.345945
FAR1 fatty acyl CoA reductase 1 0.327313
OSBPL1A oxysterol binding protein-like 1A 0.327313
SOX6 SRY (sex determining region Y)-box 6 0.327313
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.297866
DLG2 discs, large homolog 2 (Drosophila) 0.285417
CKAP5 cytoskeleton associated protein 5 0.285417
IBSP integrin-binding sialoprotein 0.274608
TOP2B topoisomerase (DNA) II beta 180kDa 0.264872
DOK6 docking protein 6 0.264872
CTNNBL1 catenin, beta like 1 0.256228
LMX1A LIM homeobox transcription factor 1, alpha 0.256228
NGLY1 N-glycanase 1 0.256228
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 0.256228
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 0.256228
TGFBR3 transforming growth factor, beta receptor III 0.256228
IL1RAP interleukin 1 receptor accessory protein 0.256228
FRMD4B FERM domain containing 4B 0.197766
TMEM182 transmembrane protein 182 0.197766
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.197766
IL21R interleukin 21 receptor 0.197766
BMS1 BMS1 ribosome biogenesis factor 0.197766
PARP4 poly (ADP-ribose) polymerase family, member 4 0.197766
UMOD uromodulin 0.197766
NPY neuropeptide Y 0.197766
ZNF518B zinc finger protein 518B 0.197766
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.15771
CNTNAP2 contactin associated protein-like 2 0.15771
RBMS3 RNA binding motif, single stranded interacting protein 3 0.15771
POSTN periostin, osteoblast specific factor 0.15771
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.15771
CASKIN2 CASK interacting protein 2 0.15771
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) 0.15771
PHACTR1 phosphatase and actin regulator 1 0.15771
CADM1 cell adhesion molecule 1 0.15771
HK2 hexokinase 2 0.15771
PDK1 pyruvate dehydrogenase kinase, isozyme 1 0.126165
FGF14 fibroblast growth factor 14 0.126165
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 0.126165
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 0.126165
SCG2 secretogranin II 0.126165
IL12B interleukin 12B 0.100789
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.100789
PLD5 phospholipase D family, member 5 0.100789
C9ORF92 chromosome 9 open reading frame 92 0.080593
HSPA13 heat shock protein 70kDa family, member 13 0.080593
TCOF1 Treacher Collins-Franceschetti syndrome 1 0.064973
KIAA1217 KIAA1217 0.064973
SAXO1 stabilizer of axonemal microtubules 1 0.052255
ETV5 ets variant 5 0.052255
TBX20 T-box 20 0.043246
FREM1 FRAS1 related extracellular matrix 1 0.043246
PABPC4L poly(A) binding protein, cytoplasmic 4-like 0.035343