bone remodeling Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis. (Gene Ontology, GO_0046849)
External Link http://amigo.geneontology.org/amigo/term/GO:0046849
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Genes

17 genes participating in the bone remodeling biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
EFNA2 ephrin-A2
EFNA4 ephrin-A4
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHA2 EPH receptor A2
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
IL6 interleukin 6
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LRP5 low density lipoprotein receptor-related protein 5
LRP6 low density lipoprotein receptor-related protein 6
LTBP3 latent transforming growth factor beta binding protein 3
MITF microphthalmia-associated transcription factor
NOTCH2 notch 2
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1
SPP2 secreted phosphoprotein 2, 24kDa
TPH1 tryptophan hydroxylase 1
WNT16 wingless-type MMTV integration site family, member 16