bone pain Gene Set

Dataset HPO Gene-Disease Associations
Category disease or phenotype associations
Type phenotype
Description An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to bone. (Human Phenotype Ontology, HP_0002653)
External Link http://compbio.charite.de/hpoweb/showterm?id=HP:0002653
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Genes

41 genes associated with the bone pain phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

Symbol Name
AGXT alanine-glyoxylate aminotransferase
CA2 carbonic anhydrase II
CLCN5 chloride channel, voltage-sensitive 5
CLCN7 chloride channel, voltage-sensitive 7
CTSK cathepsin K
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
EXT1 exostosin glycosyltransferase 1
EXT2 exostosin glycosyltransferase 2
FGF23 fibroblast growth factor 23
GBA glucosidase, beta, acid
GNAS GNAS complex locus
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
LEMD3 LEM domain containing 3
LPIN2 lipin 2
LRP5 low density lipoprotein receptor-related protein 5
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOTCH2 notch 2
PHEX phosphate regulating endopeptidase homolog, X-linked
POLE polymerase (DNA directed), epsilon, catalytic subunit
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTH1R parathyroid hormone 1 receptor
PTPN11 protein tyrosine phosphatase, non-receptor type 11
SCARB2 scavenger receptor class B, member 2
SLC34A3 solute carrier family 34 (type II sodium/phosphate cotransporter), member 3
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SNX10 sorting nexin 10
SQSTM1 sequestosome 1
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TGFB1 transforming growth factor, beta 1
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TREM2 triggering receptor expressed on myeloid cells 2
TRPS1 trichorhinophalangeal syndrome I
TYROBP TYRO protein tyrosine kinase binding protein
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WNT1 wingless-type MMTV integration site family, member 1
WNT3A wingless-type MMTV integration site family, member 3A