body mass index Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description An indicator of body density as determined by the relationship of BODY WEIGHT to BODY HEIGHT. BMI=weight (kg)/height squared (m2). BMI correlates with body fat (ADIPOSE TISSUE). Their relationship varies with age and gender. For adults, BMI falls into these categories: below 18.5 (underweight); 18.5-24.9 (normal); 25.0-29.9 (overweight); 30.0 and above (obese). (National Center for Health Statistics, Centers for Disease Control and Prevention) (Experimental Factor Ontology, EFO_0004340)
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Genes

300 genes associated with the disease body mass index in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13
ABHD12B abhydrolase domain containing 12B
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACACA acetyl-CoA carboxylase alpha
ACSS3 acyl-CoA synthetase short-chain family member 3
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional)
ADCY3 adenylate cyclase 3
ADCY9 adenylate cyclase 9
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
AGTPBP1 ATP/GTP binding protein 1
AKAP13 A kinase (PRKA) anchor protein 13
AKAP6 A kinase (PRKA) anchor protein 6
ALK anaplastic lymphoma receptor tyrosine kinase
ALOX12B arachidonate 12-lipoxygenase, 12R type
AMBP alpha-1-microglobulin/bikunin precursor
ANKRD36 ankyrin repeat domain 36
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B
ANLN anillin, actin binding protein
ANO3 anoctamin 3
ANO4 anoctamin 4
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ASB18 ankyrin repeat and SOCS box containing 18
ASIC2 acid sensing (proton gated) ion channel 2
ASTN2 astrotactin 2
ATL1 atlastin GTPase 1
ATP10A ATPase, class V, type 10A
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
ATXN1 ataxin 1
ATXN7 ataxin 7
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BBX bobby sox homolog (Drosophila)
BCDIN3D BCDIN3 domain containing
BDNF brain-derived neurotrophic factor
BMP2 bone morphogenetic protein 2
BORA bora, aurora kinase A activator
C10ORF90 chromosome 10 open reading frame 90
C2ORF61 chromosome 2 open reading frame 61
C4A complement component 4A (Rodgers blood group)
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CADM2 cell adhesion molecule 2
CCBE1 collagen and calcium binding EGF domains 1
CCDC122 coiled-coil domain containing 122
CCDC88C coiled-coil domain containing 88C
CCK cholecystokinin
CCND3 cyclin D3
CDC7 cell division cycle 7
CDH18 cadherin 18, type 2
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CMC1 C-x(9)-C motif containing 1
CMTM8 CKLF-like MARVEL transmembrane domain containing 8
CMYA5 cardiomyopathy associated 5
CNTN4 contactin 4
CNTNAP5 contactin associated protein-like 5
COL4A2 collagen, type IV, alpha 2
CPEB3 cytoplasmic polyadenylation element binding protein 3
CPNE4 copine IV
CSMD1 CUB and Sushi multiple domains 1
CTNNA2 catenin (cadherin-associated protein), alpha 2
CTNND2 catenin (cadherin-associated protein), delta 2
CYFIP1 cytoplasmic FMR1 interacting protein 1
DAAM2 dishevelled associated activator of morphogenesis 2
DDO D-aspartate oxidase
DEFB112 defensin, beta 112
DGKG diacylglycerol kinase, gamma 90kDa
DGKI diacylglycerol kinase, iota
DIO1 deiodinase, iodothyronine, type I
DLGAP1 discs, large (Drosophila) homolog-associated protein 1
DMD dystrophin
DNAH6 dynein, axonemal, heavy chain 6
DOCK11 dedicator of cytokinesis 11
DPP6 dipeptidyl-peptidase 6
DPYD dihydropyrimidine dehydrogenase
EBF2 early B-cell factor 2
ELMO1 engulfment and cell motility 1
ELSPBP1 epididymal sperm binding protein 1
EPAS1 endothelial PAS domain protein 1
ERC1 ELKS/RAB6-interacting/CAST family member 1
ETV5 ets variant 5
EVA1A eva-1 homolog A (C. elegans)
FABP2 fatty acid binding protein 2, intestinal
FAIM2 Fas apoptotic inhibitory molecule 2
FAM172A family with sequence similarity 172, member A
FAM174A family with sequence similarity 174, member A
FAM178B family with sequence similarity 178, member B
FAM19A2 family with sequence similarity 19 (chemokine (C-C motif)-like), member A2
FAM20B family with sequence similarity 20, member B
FAM53B family with sequence similarity 53, member B
FBN1 fibrillin 1
FGD4 FYVE, RhoGEF and PH domain containing 4
FHIT fragile histidine triad
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FMN2 formin 2
FOXN3 forkhead box N3
FRMD6 FERM domain containing 6
FTO fat mass and obesity associated
FUT10 fucosyltransferase 10 (alpha (1,3) fucosyltransferase)
GABPB1 GA binding protein transcription factor, beta subunit 1
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GADL1 glutamate decarboxylase-like 1
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6
GBX1 gastrulation brain homeobox 1
GIPR gastric inhibitory polypeptide receptor
GLI3 GLI family zinc finger 3
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GNPDA2 glucosamine-6-phosphate deaminase 2
GPR176 G protein-coupled receptor 176
GRIK1 glutamate receptor, ionotropic, kainate 1
GRM7 glutamate receptor, metabotropic 7
GRM8 glutamate receptor, metabotropic 8
GZF1 GDNF-inducible zinc finger protein 1
HAS3 hyaluronan synthase 3
HELZ helicase with zinc finger
HHIP hedgehog interacting protein
HIBCH 3-hydroxyisobutyryl-CoA hydrolase
HSPH1 heat shock 105kDa/110kDa protein 1
IGHMBP2 immunoglobulin mu binding protein 2
IL22RA2 interleukin 22 receptor, alpha 2
IL26 interleukin 26
IQGAP2 IQ motif containing GTPase activating protein 2
IRS2 insulin receptor substrate 2
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
ITK IL2-inducible T-cell kinase
KALRN kalirin, RhoGEF kinase
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1
KCNIP4 Kv channel interacting protein 4
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KCNT1 potassium channel, sodium activated subfamily T, member 1
KCTD15 potassium channel tetramerization domain containing 15
KDM4C lysine (K)-specific demethylase 4C
KIF1B kinesin family member 1B
KLHL29 kelch-like family member 29
KMT2E lysine (K)-specific methyltransferase 2E
LAMA1 laminin, alpha 1
LAMA2 laminin, alpha 2
LCT lactase
LDB2 LIM domain binding 2
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LINGO2 leucine rich repeat and Ig domain containing 2
LMNTD1 lamin tail domain containing 1
LPP LIM domain containing preferred translocation partner in lipoma
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LRP1B low density lipoprotein receptor-related protein 1B
LRRC4B leucine rich repeat containing 4B
MANBA mannosidase, beta A, lysosomal
MAP2K5 mitogen-activated protein kinase kinase 5
MARCH5 membrane-associated ring finger (C3HC4) 5
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MARK1 MAP/microtubule affinity-regulating kinase 1
MC4R melanocortin 4 receptor
MCTP1 multiple C2 domains, transmembrane 1
MCTP2 multiple C2 domains, transmembrane 2
MEGF11 multiple EGF-like-domains 11
MEIS2 Meis homeobox 2
MEX3B mex-3 RNA binding family member B
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MLIP muscular LMNA-interacting protein
MMP1 matrix metallopeptidase 1
MNAT1 MNAT CDK-activating kinase assembly factor 1
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
MRPL52 mitochondrial ribosomal protein L52
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MTCH2 mitochondrial carrier 2
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
MTIF3 mitochondrial translational initiation factor 3
MTMR7 myotubularin related protein 7
MYO1B myosin IB
MYOM3 myomesin 3
MYRIP myosin VIIA and Rab interacting protein
NEGR1 neuronal growth regulator 1
NELL1 NEL-like 1 (chicken)
NFE2L1 nuclear factor, erythroid 2-like 1
NKAIN2 Na+/K+ transporting ATPase interacting 2
NMS neuromedin S
NPAS3 neuronal PAS domain protein 3
NPY4R neuropeptide Y receptor Y4
NR3C2 nuclear receptor subfamily 3, group C, member 2
NRXN3 neurexin 3
NTNG1 netrin G1
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3
NUP93 nucleoporin 93kDa
OPCML opioid binding protein/cell adhesion molecule-like
OSBPL9 oxysterol binding protein-like 9
OXR1 oxidation resistance 1
PARK2 parkin RBR E3 ubiquitin protein ligase
PCDHA1 protocadherin alpha 1
PCDHA10 protocadherin alpha 10
PCDHA11 protocadherin alpha 11
PCDHA12 protocadherin alpha 12
PCDHA13 protocadherin alpha 13
PCDHA2 protocadherin alpha 2
PCDHA3 protocadherin alpha 3
PCDHA4 protocadherin alpha 4
PCDHA5 protocadherin alpha 5
PCDHA6 protocadherin alpha 6
PCDHA7 protocadherin alpha 7
PCDHA8 protocadherin alpha 8
PCDHA9 protocadherin alpha 9
PCDHAC1 protocadherin alpha subfamily C, 1
PCDHAC2 protocadherin alpha subfamily C, 2
PCDHB2 protocadherin beta 2
PCDHB3 protocadherin beta 3
PCGF3 polycomb group ring finger 3
PDGFRL platelet-derived growth factor receptor-like
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1
PKP1 plakophilin 1
PLCB4 phospholipase C, beta 4
PLCH1 phospholipase C, eta 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLXDC2 plexin domain containing 2
POC5 POC5 centriolar protein
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma
PTN pleiotrophin
PTPRD protein tyrosine phosphatase, receptor type, D
PTPRO protein tyrosine phosphatase, receptor type, O
QPCTL glutaminyl-peptide cyclotransferase-like
RAB28 RAB28, member RAS oncogene family
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1
RASAL2 RAS protein activator like 2
RASSF6 Ras association (RalGDS/AF-6) domain family member 6
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RGS8 regulator of G-protein signaling 8
RIT2 Ras-like without CAAX 2
ROPN1L rhophilin associated tail protein 1-like
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCFD2 sec1 family domain containing 2
SCML4 sex comb on midleg-like 4 (Drosophila)
SDC2 syndecan 2
SEC16B SEC16 homolog B (S. cerevisiae)
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SFMBT1 Scm-like with four mbt domains 1
SH2B1 SH2B adaptor protein 1
SHISA6 shisa family member 6
SLC14A2 solute carrier family 14 (urea transporter), member 2
SLC16A12 solute carrier family 16, member 12
SLC35F1 solute carrier family 35, member F1
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2
SLC38A6 solute carrier family 38, member 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC44A5 solute carrier family 44, member 5
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
SLIT3 slit homolog 3 (Drosophila)
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1
SMCP sperm mitochondria-associated cysteine-rich protein
SMOC1 SPARC related modular calcium binding 1
SNX24 sorting nexin 24
SOS1 son of sevenless homolog 1 (Drosophila)
SOX5 SRY (sex determining region Y)-box 5
SPTSSB serine palmitoyltransferase, small subunit B
SRI sorcin
SRPK2 SRSF protein kinase 2
STAU2 staufen double-stranded RNA binding protein 2
STK33 serine/threonine kinase 33
STXBP4 syntaxin binding protein 4
SYCP1 synaptonemal complex protein 1
SYT1 synaptotagmin I
TBC1D32 TBC1 domain family, member 32
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TENM4 teneurin transmembrane protein 4
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THSD7A thrombospondin, type I, domain containing 7A
TIFA TRAF-interacting protein with forkhead-associated domain
TLR4 toll-like receptor 4
TMEM117 transmembrane protein 117
TMEM154 transmembrane protein 154
TMEM18 transmembrane protein 18
TMTC1 transmembrane and tetratricopeptide repeat containing 1
TMTC2 transmembrane and tetratricopeptide repeat containing 2
TNIP3 TNFAIP3 interacting protein 3
TNNI3K TNNI3 interacting kinase
TPD52L1 tumor protein D52-like 1
TRA2B transformer 2 beta homolog (Drosophila)
TRAPPC9 trafficking protein particle complex 9
TRMT5 tRNA methyltransferase 5
TSPAN2 tetraspanin 2
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UNC13C unc-13 homolog C (C. elegans)
VEGFC vascular endothelial growth factor C
VIT vitrin
VWA8 von Willebrand factor A domain containing 8
WDFY4 WDFY family member 4
WWOX WW domain containing oxidoreductase
XYLT1 xylosyltransferase I
ZC3H4 zinc finger CCCH-type containing 4
ZFHX2 zinc finger homeobox 2
ZFHX3 zinc finger homeobox 3
ZNF532 zinc finger protein 532
ZNF804B zinc finger protein 804B
ZSCAN31 zinc finger and SCAN domain containing 31