bisoprolol-2642 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the bisoprolol-2642 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMH anti-Mullerian hormone
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
C11ORF63 chromosome 11 open reading frame 63
C1QL1 complement component 1, q subcomponent-like 1
C2ORF68 chromosome 2 open reading frame 68
CA4 carbonic anhydrase IV
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CCL21 chemokine (C-C motif) ligand 21
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDH8 cadherin 8, type 2
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
CLDN11 claudin 11
CLDN6 claudin 6
CLPS colipase, pancreatic
CLUAP1 clusterin associated protein 1
CNOT4 CCR4-NOT transcription complex, subunit 4
CNPPD1 cyclin Pas1/PHO80 domain containing 1
COL21A1 collagen, type XXI, alpha 1
COL6A1 collagen, type VI, alpha 1
DAPK2 death-associated protein kinase 2
DCAF4 DDB1 and CUL4 associated factor 4
DIAPH2 diaphanous-related formin 2
DLX2 distal-less homeobox 2
EDDM3B epididymal protein 3B
FAM131A family with sequence similarity 131, member A
FGF16 fibroblast growth factor 16
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
GFOD1 glucose-fructose oxidoreductase domain containing 1
GLS glutaminase
GSTA3 glutathione S-transferase alpha 3
HNF1B HNF1 homeobox B
HR hair growth associated
ICAM5 intercellular adhesion molecule 5, telencephalin
IGFBP5 insulin-like growth factor binding protein 5
IQCG IQ motif containing G
IRF2BP1 interferon regulatory factor 2 binding protein 1
JUN jun proto-oncogene
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KCTD12 potassium channel tetramerization domain containing 12
KCTD20 potassium channel tetramerization domain containing 20
KDM4C lysine (K)-specific demethylase 4C
KEL Kell blood group, metallo-endopeptidase
KRT37 keratin 37, type I
LOC399491
MAP9 microtubule-associated protein 9
MINK1 misshapen-like kinase 1
MITF microphthalmia-associated transcription factor
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MOGAT2 monoacylglycerol O-acyltransferase 2
NEK1 NIMA-related kinase 1
NMT1 N-myristoyltransferase 1
NOP16 NOP16 nucleolar protein
NOS1 nitric oxide synthase 1 (neuronal)
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NSUN6 NOP2/Sun domain family, member 6
PAIP2B poly(A) binding protein interacting protein 2B
PLD3 phospholipase D family, member 3
PLK4 polo-like kinase 4
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRDX2 peroxiredoxin 2
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTGER3 prostaglandin E receptor 3 (subtype EP3)
QPCT glutaminyl-peptide cyclotransferase
RAG2 recombination activating gene 2
RBMS3 RNA binding motif, single stranded interacting protein 3
RPS28 ribosomal protein S28
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SAG S-antigen; retina and pineal gland (arrestin)
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SIN3B SIN3 transcription regulator family member B
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SSBP1 single-stranded DNA binding protein 1, mitochondrial
STEAP1 six transmembrane epithelial antigen of the prostate 1
SUGP1 SURP and G patch domain containing 1
TLX1 T-cell leukemia homeobox 1
TPMT thiopurine S-methyltransferase
TSPAN2 tetraspanin 2
TTLL5 tubulin tyrosine ligase-like family member 5
TYRP1 tyrosinase-related protein 1
UBOX5 U-box domain containing 5
UTS2 urotensin 2
VASH2 vasohibin 2
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
WDR61 WD repeat domain 61
WNT16 wingless-type MMTV integration site family, member 16
XDH xanthine dehydrogenase
ZFAND5 zinc finger, AN1-type domain 5
ZNF778 zinc finger protein 778

decreased expression

Symbol Name
ABLIM3 actin binding LIM protein family, member 3
ADGRE5 adhesion G protein-coupled receptor E5
AHR aryl hydrocarbon receptor
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ARMC6 armadillo repeat containing 6
BIRC7 baculoviral IAP repeat containing 7
BMP4 bone morphogenetic protein 4
C17ORF80 chromosome 17 open reading frame 80
C21ORF91 chromosome 21 open reading frame 91
CCP110 centriolar coiled coil protein 110kDa
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDK3 cyclin-dependent kinase 3
CENPQ centromere protein Q
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CRYBB2P1 crystallin, beta B2 pseudogene 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DGKE diacylglycerol kinase, epsilon 64kDa
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DSCAM Down syndrome cell adhesion molecule
DUSP13 dual specificity phosphatase 13
DYSF dysferlin
EMID1 EMI domain containing 1
FBXO31 F-box protein 31
FSD1 fibronectin type III and SPRY domain containing 1
GAB2 GRB2-associated binding protein 2
GEMIN8 gem (nuclear organelle) associated protein 8
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GRPR gastrin-releasing peptide receptor
GSTT1 glutathione S-transferase theta 1
HAUS6 HAUS augmin-like complex, subunit 6
HIRIP3 HIRA interacting protein 3
HIST1H2BO histone cluster 1, H2bo
HIST1H4D histone cluster 1, H4d
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
JMJD4 jumonji domain containing 4
KIF18B kinesin family member 18B
LARP6 La ribonucleoprotein domain family, member 6
LHX1 LIM homeobox 1
LRRC8E leucine rich repeat containing 8 family, member E
LY6G6C lymphocyte antigen 6 complex, locus G6C
LYPD1 LY6/PLAUR domain containing 1
MANBA mannosidase, beta A, lysosomal
MED15 mediator complex subunit 15
METTL8 methyltransferase like 8
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
NBEAL2 neurobeachin-like 2
NDE1 nudE neurodevelopment protein 1
NECAP2 NECAP endocytosis associated 2
NES nestin
NIPAL2 NIPA-like domain containing 2
NKAIN1 Na+/K+ transporting ATPase interacting 1
NPM3 nucleophosmin/nucleoplasmin 3
NRSN2 neurensin 2
NSD1 nuclear receptor binding SET domain protein 1
NT5C 5', 3'-nucleotidase, cytosolic
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PADI1 peptidyl arginine deiminase, type I
PHEX phosphate regulating endopeptidase homolog, X-linked
PLA2G10 phospholipase A2, group X
POLL polymerase (DNA directed), lambda
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PRICKLE3 prickle homolog 3 (Drosophila)
PRR14L proline rich 14-like
RARS arginyl-tRNA synthetase
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RIPK4 receptor-interacting serine-threonine kinase 4
RNF122 ring finger protein 122
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPL13P5 ribosomal protein L13 pseudogene 5
SCD5 stearoyl-CoA desaturase 5
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SNAI2 snail family zinc finger 2
SPINK4 serine peptidase inhibitor, Kazal type 4
SPINK5 serine peptidase inhibitor, Kazal type 5
STAG3 stromal antigen 3
STX1A syntaxin 1A (brain)
STXBP2 syntaxin binding protein 2
SUN2 Sad1 and UNC84 domain containing 2
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TPCN1 two pore segment channel 1
TWF2 twinfilin actin binding protein 2
UBXN6 UBX domain protein 6
UFSP2 UFM1-specific peptidase 2
USB1 U6 snRNA biogenesis 1
WDR19 WD repeat domain 19
ZC3H3 zinc finger CCCH-type containing 3
ZDHHC14 zinc finger, DHHC-type containing 14
ZDHHC18 zinc finger, DHHC-type containing 18
ZNF189 zinc finger protein 189
ZNF573 zinc finger protein 573
ZXDC ZXD family zinc finger C