bicuculline-4574 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the bicuculline-4574 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACTG2 actin, gamma 2, smooth muscle, enteric
ADD2 adducin 2 (beta)
ADRB3 adrenoceptor beta 3
AHSP alpha hemoglobin stabilizing protein
AKAP5 A kinase (PRKA) anchor protein 5
ASPHD1 aspartate beta-hydroxylase domain containing 1
BBC3 BCL2 binding component 3
BMP7 bone morphogenetic protein 7
C11ORF63 chromosome 11 open reading frame 63
C17ORF59 chromosome 17 open reading frame 59
C22ORF24 chromosome 22 open reading frame 24
C2CD2L C2CD2-like
C3 complement component 3
CCDC186 coiled-coil domain containing 186
CLCN1 chloride channel, voltage-sensitive 1
CLIC2 chloride intracellular channel 2
CNTNAP2 contactin associated protein-like 2
CREM cAMP responsive element modulator
DACH1 dachshund family transcription factor 1
DGCR5 DiGeorge syndrome critical region gene 5 (non-protein coding)
DGKE diacylglycerol kinase, epsilon 64kDa
DLC1 DLC1 Rho GTPase activating protein
DOCK6 dedicator of cytokinesis 6
DOK4 docking protein 4
ESRRG estrogen-related receptor gamma
EVI2A ecotropic viral integration site 2A
FBXO41 F-box protein 41
FGF1 fibroblast growth factor 1 (acidic)
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GPR17 G protein-coupled receptor 17
HCFC1 host cell factor C1
HNF1B HNF1 homeobox B
HOXC5 homeobox C5
HSPA12A heat shock 70kDa protein 12A
IGL immunoglobulin lambda locus
IL36RN interleukin 36 receptor antagonist
IL5RA interleukin 5 receptor, alpha
ITGA7 integrin, alpha 7
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KIAA0040 KIAA0040
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRIT1 KRIT1, ankyrin repeat containing
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MBD2 methyl-CpG binding domain protein 2
MCTP2 multiple C2 domains, transmembrane 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METTL7A methyltransferase like 7A
MFAP3 microfibrillar-associated protein 3
MFAP3L microfibrillar-associated protein 3-like
MTMR3 myotubularin related protein 3
MTSS1L metastasis suppressor 1-like
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NEURL1 neuralized E3 ubiquitin protein ligase 1
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NRG1 neuregulin 1
PALM paralemmin
PCDHB3 protocadherin beta 3
PDE4DIP phosphodiesterase 4D interacting protein
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHOX2A paired-like homeobox 2a
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PNMAL1 paraneoplastic Ma antigen family-like 1
POU4F1 POU class 4 homeobox 1
PSD4 pleckstrin and Sec7 domain containing 4
RABGAP1L RAB GTPase activating protein 1-like
RAG1 recombination activating gene 1
RGS5 regulator of G-protein signaling 5
SC5D sterol-C5-desaturase
SCEL sciellin
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
SLC17A2 solute carrier family 17, member 2
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
SPPL2B signal peptide peptidase like 2B
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
TEF thyrotrophic embryonic factor
TESPA1 thymocyte expressed, positive selection associated 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TINAGL1 tubulointerstitial nephritis antigen-like 1
TLN2 talin 2
TTC12 tetratricopeptide repeat domain 12
U2AF2 U2 small nuclear RNA auxiliary factor 2
VAC14 Vac14 homolog (S. cerevisiae)
VDAC3 voltage-dependent anion channel 3
WDR59 WD repeat domain 59
WIPF1 WAS/WASL interacting protein family, member 1
WSB1 WD repeat and SOCS box containing 1
YIPF4 Yip1 domain family, member 4
ZCCHC14 zinc finger, CCHC domain containing 14
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF225 zinc finger protein 225
ZNF44 zinc finger protein 44
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ACAD10 acyl-CoA dehydrogenase family, member 10
AOC2 amine oxidase, copper containing 2 (retina-specific)
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
C14ORF93 chromosome 14 open reading frame 93
C5ORF45 chromosome 5 open reading frame 45
C6ORF47 chromosome 6 open reading frame 47
C7ORF43 chromosome 7 open reading frame 43
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CAPN15 calpain 15
CDK6 cyclin-dependent kinase 6
CES3 carboxylesterase 3
CHRDL1 chordin-like 1
CLCA1 chloride channel accessory 1
CLSTN3 calsyntenin 3
CNTLN centlein, centrosomal protein
DBF4B DBF4 zinc finger B
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DENND2D DENN/MADD domain containing 2D
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DPF3 D4, zinc and double PHD fingers, family 3
DSPP dentin sialophosphoprotein
DTX2 deltex 2, E3 ubiquitin ligase
DUSP9 dual specificity phosphatase 9
ELAVL3 ELAV like neuron-specific RNA binding protein 3
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ERO1LB ERO1-like beta (S. cerevisiae)
FA2H fatty acid 2-hydroxylase
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FLCN folliculin
HIST1H2BO histone cluster 1, H2bo
HIST1H4A histone cluster 1, H4a
HOXA1 homeobox A1
IFNA14 interferon, alpha 14
INCENP inner centromere protein antigens 135/155kDa
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
ITK IL2-inducible T-cell kinase
ITPKA inositol-trisphosphate 3-kinase A
KDM7A lysine (K)-specific demethylase 7A
KLF13 Kruppel-like factor 13
LAMC3 laminin, gamma 3
LMCD1 LIM and cysteine-rich domains 1
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LY6D lymphocyte antigen 6 complex, locus D
LY96 lymphocyte antigen 96
MAPK7 mitogen-activated protein kinase 7
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MDFI MyoD family inhibitor
MEGF8 multiple EGF-like-domains 8
MMRN2 multimerin 2
MTMR11 myotubularin related protein 11
MUC3B mucin 3B, cell surface associated
MX1 MX dynamin-like GTPase 1
MYLK myosin light chain kinase
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NDRG4 NDRG family member 4
NME5 NME/NM23 family member 5
NPFFR1 neuropeptide FF receptor 1
NT5DC3 5'-nucleotidase domain containing 3
NT5M 5',3'-nucleotidase, mitochondrial
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PDE12 phosphodiesterase 12
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PEX26 peroxisomal biogenesis factor 26
PICK1 protein interacting with PRKCA 1
PLA2G1B phospholipase A2, group IB (pancreas)
PLAC8 placenta-specific 8
PRB3 proline-rich protein BstNI subfamily 3
PROX1 prospero homeobox 1
R3HCC1L R3H domain and coiled-coil containing 1-like
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RNF126P1 ring finger protein 126 pseudogene 1
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
SCIN scinderin
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SLITRK5 SLIT and NTRK-like family, member 5
SLMO1 slowmo homolog 1 (Drosophila)
SNHG3 small nucleolar RNA host gene 3
SREK1IP1 SREK1-interacting protein 1
STX17 syntaxin 17
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
THRAP3 thyroid hormone receptor associated protein 3
TSC22D4 TSC22 domain family, member 4
TTC30A tetratricopeptide repeat domain 30A
TUBA3C tubulin, alpha 3c
TUBA4B tubulin, alpha 4b
TUBB2B tubulin, beta 2B class IIb
USP19 ubiquitin specific peptidase 19
WDR4 WD repeat domain 4
WNT7A wingless-type MMTV integration site family, member 7A
ZC3H12A zinc finger CCCH-type containing 12A
ZNF343 zinc finger protein 343
ZNF76 zinc finger protein 76