beta-catenin destruction complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome. (Gene Ontology, GO_0030877)
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Genes

89 proteins co-occuring with the beta-catenin destruction complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
AXIN1 axin 1 2.62692
SIAH1 siah E3 ubiquitin protein ligase 1 1.99476
GSK3B glycogen synthase kinase 3 beta 1.76626
APC adenomatous polyposis coli 1.61295
HNF4A hepatocyte nuclear factor 4, alpha 1.58449
CACYBP calcyclin binding protein 1.57989
DVL1 dishevelled segment polarity protein 1 1.30067
AXIN2 axin 2 1.26445
LEF1 lymphoid enhancer-binding factor 1 1.22932
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 1.1685
ANKRD6 ankyrin repeat domain 6 1.00103
CCND1 cyclin D1 0.999068
DVL3 dishevelled segment polarity protein 3 0.918579
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 0.910647
WNT3A wingless-type MMTV integration site family, member 3A 0.887936
WNT4 wingless-type MMTV integration site family, member 4 0.88286
LRP5 low density lipoprotein receptor-related protein 5 0.877791
SKP1 S-phase kinase-associated protein 1 0.763617
NEURL2 neuralized E3 ubiquitin protein ligase 2 0.761797
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.728836
LRP6 low density lipoprotein receptor-related protein 6 0.723472
CSN1S1 casein alpha s1 0.692516
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) 0.68639
SIAH2 siah E3 ubiquitin protein ligase 2 0.663368
S100A12 S100 calcium binding protein A12 0.648721
HSPA6 heat shock 70kDa protein 6 (HSP70B') 0.627335
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 0.624355
FZD1 frizzled class receptor 1 0.622229
DOCK4 dedicator of cytokinesis 4 0.603174
SPATA13 spermatogenesis associated 13 0.581758
CSNK1E casein kinase 1, epsilon 0.570913
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.563017
S100P S100 calcium binding protein P 0.529208
CUL1 cullin 1 0.520206
BCL9 B-cell CLL/lymphoma 9 0.519389
WNT1 wingless-type MMTV integration site family, member 1 0.515308
STK4 serine/threonine kinase 4 0.503099
PRPF4B pre-mRNA processing factor 4B 0.50107
TLK1 tousled-like kinase 1 0.492157
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.484483
S100A1 S100 calcium binding protein A1 0.470406
PRKD3 protein kinase D3 0.457208
USP15 ubiquitin specific peptidase 15 0.452825
PARK2 parkin RBR E3 ubiquitin protein ligase 0.452427
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.446465
HSPH1 heat shock 105kDa/110kDa protein 1 0.442896
CSNK1D casein kinase 1, delta 0.440124
FZD9 frizzled class receptor 9 0.433012
TP53 tumor protein p53 0.427891
S100A6 S100 calcium binding protein A6 0.427104
CHRD chordin 0.42082
NLK nemo-like kinase 0.420036
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.420036
KCNIP4 Kv channel interacting protein 4 0.400527
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 0.380045
S100B S100 calcium binding protein B 0.37505
FZD6 frizzled class receptor 6 0.374283
CHKA choline kinase alpha 0.364713
KIFAP3 kinesin-associated protein 3 0.36204
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.357086
MARK2 MAP/microtubule affinity-regulating kinase 2 0.356324
JUN jun proto-oncogene 0.343799
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4 0.339639
S100A7 S100 calcium binding protein A7 0.339261
PLK4 polo-like kinase 4 0.331342
ICAM5 intercellular adhesion molecule 5, telencephalin 0.329837
WNT5A wingless-type MMTV integration site family, member 5A 0.325702
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 0.31783
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 0.29623
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.291787
SDHAF2 succinate dehydrogenase complex assembly factor 2 0.291047
HIPK2 homeodomain interacting protein kinase 2 0.287352
MAPK8 mitogen-activated protein kinase 8 0.257289
ANXA3 annexin A3 0.252927
EN1 engrailed homeobox 1 0.233817
CTNNBIP1 catenin, beta interacting protein 1 0.21681
SMAD7 SMAD family member 7 0.203361
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 0.201335
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.195353
DVL2 dishevelled segment polarity protein 2 0.191777
ADAR adenosine deaminase, RNA-specific 0.190814
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.182723
OTX2 orthodenticle homeobox 2 0.18093
AR androgen receptor 0.176024
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 0.175188
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.170114
SFRP1 secreted frizzled-related protein 1 0.16935
MAPK14 mitogen-activated protein kinase 14 0.167125
HSPA1B heat shock 70kDa protein 1B 0.165932